Z
Zongliang Jiang
Researcher at Louisiana State University
Publications - 45
Citations - 939
Zongliang Jiang is an academic researcher from Louisiana State University. The author has contributed to research in topics: DNA methylation & Embryo. The author has an hindex of 15, co-authored 37 publications receiving 572 citations. Previous affiliations of Zongliang Jiang include University of Connecticut & Yale University.
Papers
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Journal ArticleDOI
Transcriptional profiles of bovine in vivo pre-implantation development.
Zongliang Jiang,Jiangwen Sun,Dong Hong,Oscar Junhong Luo,Zheng Xinbao,Craig Obergfell,Yong Tang,Jinbo Bi,Rachel J. O’Neill,Yijun Ruan,Jingbo Chen,Xiuchun Cindy Tian +11 more
TL;DR: This study provides a comprehensive examination of gene activities in bovine embryos and identified little-known potential master regulators of pre-implantation development, demonstrating that bovines are better models for human embryonic development.
Journal ArticleDOI
Jak/Stat3 signaling promotes somatic cell reprogramming by epigenetic regulation.
Yong Tang,Yan Luo,Zongliang Jiang,Yinghong Ma,Chih-Jen Lin,Chul Kim,Mark G. Carter,Tomokazu Amano,Joonghong Park,Sharon Kish,Xiuchun Cindy Tian +10 more
TL;DR: It is concluded that Jak/Stat3 activity plays a fundamental role to promote pluripotency establishment at the epigenetic level, by facilitating DNA demethylation/de novo methylation, and open‐chromatin formation during late‐stage reprogramming.
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Mitochondrial dysfunction and ovarian aging.
TL;DR: Mitochondria are double‐membrane‐bound organelles that are responsible for the generation of most of the cell's energy and have been implicated in cellular senescence in general and ovarian aging in particular.
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Mitochondrial unfolded protein response gene Clpp is required to maintain ovarian follicular reserve during aging, for oocyte competence, and development of pre-implantation embryos.
Tianren Wang,Tianren Wang,Elnur Babayev,Zongliang Jiang,Guangxin Li,Man Zhang,Ecem Esencan,Tamas L. Horvath,Emre Seli +8 more
TL;DR: It is demonstrated that CLPP is required for oocyte and embryo development and oocyte mitochondrial function and dynamics, and absence of CLPP results in mTOR pathway activation, and accelerated depletion of ovarian follicular reserve.
Journal ArticleDOI
Mitofusin 1 is required for female fertility and to maintain ovarian follicular reserve
Man Zhang,Muhammed Burak Bener,Zongliang Jiang,Zongliang Jiang,Tianren Wang,Ecem Esencan,Richard T. Scott,Tamas L. Horvath,Emre Seli +8 more
TL;DR: Targeted deletion of mitochondrial fusion protein mitofusin1 (MFN1) in oocytes resulted in female infertility associated with failure to achieve oocyte maturation and a phenotype consistent with accelerated female reproductive aging.