Zongliang Jiang

TL;DR: In this paper, gene expression profiling and genome-wide accessible chromatin mapping of mouse cardiac fibroblasts isolated from the uninjured myocardium and the infarct at multiple time points corresponding to different differentiation states were performed by RNA sequencing (RNA-seq) and the assay for transposase-accessible chromatin with high-throughput sequencing (ATAC-seq), respectively.

TL;DR: The findings confirm Ohno’s hypothesis of X dosage compensation in the bovine and extend it by showing incomplete and over-compensation for expressed and “dosage-sensitive” genes, respectively.

TL;DR: Co-regulated genes consistent between the human and mouse were identified, offering insights into conserved functions, as well as similarities and differences in genome activation timing between thehuman and mouse embryos.

TL;DR: The transcriptome for goat preimplantation embryo development was defined and conserved key members (or hub genes) of the goat transcriptional networks were identified, suggesting they may have important regulatory roles in embryo development.

TL;DR: Evaluated the effect of vitrification on the transcriptome dynamics of D14 embryos by RNA sequencing and identified specific pathways and implicated specific genes affected by cryopreservation and potentially affecting embryo developmental competence.