Zsuzsanna Tucsek

TL;DR: Obesity in aging is associated with a heightened state of systemic inflammation, which exacerbates blood-brain barrier disruption, and the resulting neuroinflammation and oxidative stress in the mouse hippocampus likely contribute to the significant cognitive decline observed in aged obese animals.

TL;DR: In this paper, the specific mechanisms through which aging and obesity interact to promote cognitive function in the elderly were investigated, and it was shown that obesity has deleterious effects on the brain and cognitive function.

TL;DR: Test the hypothesis that restoring NAD+ concentration may exert beneficial effects on NVC responses in aging by treating 24-month-old C57BL/6 mice with nicotinamide mononucleotide (NMN), a key NAD+ intermediate, and found thatNVC responses were significantly impaired in aged mice.

TL;DR: It is found that aging exacerbates the obesity-induced decline in microvascular density both in the hippocampus and in the cortex, which likely contribute to obesity- induced cognitive decline in aging.

TL;DR: It is demonstrated that IGF‐1 deficiency promotes cerebromicrovascular dysfunction and neurovascular uncoupling mimicking the aging phenotype, which is likely to contribute to cognitive impairment.