Showing papers by "Cancer Epidemiology Unit published in 1985"
TL;DR: An excess of non-Hodgkin's lymphoma and squamous cell skin cancer is found among patients without transplants treated with immunosuppressive drugs, suggesting that the excesses (although larger) of the same malignancies found among transplant recipients are not due solely to the foreign antigens of the graft.
369 citations
TL;DR: Among 377 patients with primary hypogammaglobulinaemia, mainly common variable immunodeficiency (CVID), 316 patients survived the first 2 years after diagnosis and were the subject of a study of cancer incidence.
275 citations
TL;DR: Using the data base of chemicals tested by the NCI Bioassay Program, it is observed that there is a very high correlation of the maximum doses tested (max-d) for rats and mice on a milligram per kilogram body weight per day basis.
113 citations
TL;DR: The incidence of melanoma was correlated with other sites of cancer across populations for both sexes separately, showing a high correlation with ovarian cancer and the correlation study emphasizes the importance of the endogenous factors.
13 citations
TL;DR: It is demonstrated that the potency of a carcinogen is restncted to an approximately thirty-fold range, about the maximum dose tested in the experiment in the absence of 100% tumor incidence in treated animals.
Abstract: In our recent paper,‘’) we called attention to some of the points raised by Wlupple and by Zeise, Crouch, and Wilson. Our interest in this subject developed as we began analyzing our database of animal carcinogenesis bioas~ays.(*~~)In our analyses, we used as a measure of carcinogenic potency, the TD,,, defined as the dose rate (in mg/kg/body wt/day) which, if administered chronically for a standard period, would halve the probability of an animal remaining tumorless. By analogy with LD,,, the TD,, is that daily dose which would induce tumors in half of the animals that would have remained tumor-free at zero dose. We demonstrated that the potency of a carcinogen is restncted to an approximately thirty-fold range, about the maximum dose tested in the experiment in the absence of 100% tumor incidence in treated animals. The maximally tolerated doses (MTDs) of chemicals tested in chronic animal bioassays span a range of seven orders of magnitude, and these doses are highly correlated between rats and mice. These fact, together with the restricted range of potency about the MTD, (1) account for hgh correlations in carcinogenic potency between rats and mice, and (2) provide a statistical basis for the relationship between potency values and MTDs. One would expect to observe a similar relationship between carcinogenic potency (TD,,) and LD,,, qssuming that the acute and the chronic toxic doses are related.
12 citations