Showing papers by "Eastern Cooperative Oncology Group published in 1986"
TL;DR: A collaborative study with the hope of resolving some of the controversies regarding the criteria and methods for the subclassification of follicular lymphomas found that the patient population could be separated into at least two prognostic groups, for SNC and/or LNC and for S NC + LNC + LC cells.
80 citations
TL;DR: The results indicate that high acid mucopolysaccharide content in GBA significantly improves prognosis, and ECOG recommends stratification by acid mucpolysaccharid content in future GBA treatment investigations.
Abstract: The gall bladder mucosa is composed of neutral mucopolysaccharide and protein radical containing secretory cells, protein radical containing migratory cells, and neutral and acid mucopolysaccharides plus sialic acid containing goblet cells. The prognostic significance of histologic or histochemical parameters in gall bladder adenocarcinoma (GBA) are unknown. To determine if histochemical acid mucopolysaccharide content in GBA has prognostic value, GBA histologic sections from 26 advanced stage disease patients participating in Eastern Cooperative Oncology Group (ECOG) treatment study EST-2273 were stained with alcian blue at pH. 1.0, assessed by a pathology panel for either high (greater than 50%) or low (less than 50%) acid mucopolysaccharide content, and correlated with patient survival. Initial panel unanimous concurrence rate on acid mucopolysaccharide content was 88.9%. Median survival times from the start of chemotherapy to date of death for high acid mucopolysaccharide content GBA was 14 weeks versus five weeks for the low content GBA (P less than 0.0001). The results indicate that high acid mucopolysaccharide content in GBA significantly improves prognosis. ECOG recommends stratification by acid mucopolysaccharide content in future GBA treatment investigations.
3 citations