Fujian Provincial Cancer Hospital

About: Fujian Provincial Cancer Hospital is a healthcare organization based out in . It is known for research contribution in the topics: Medicine & Computer science. The organization has 7 authors who have published 16 publications receiving 115 citations.

A High‐Lift Micro‐Aerial‐Robot Powered by Low‐Voltage and Long‐Endurance Dielectric Elastomer Actuators

Abstract: Dielectric elastomer actuators (DEAs) are a special class of artificial muscles that have been used to construct animal-like soft robotic systems. However, compared with state-of-the-art rigid actuators such as piezoelectric bimorphs and electromagnetic motors, most DEAs require higher driving voltages, and their power density and lifetime remain substantially lower. These limitations pose significant challenges for developing agile and powered autonomous soft robots. Here, a low-voltage, high-endurance, and power-dense DEA based on novel multiple-layering techniques and electrode-material optimization, is reported. When operated at 400 Hz, the 143 mg DEA generates forces of 0.36 N and displacements of 1.15 mm. This DEA is incorporated into an aerial robot to demonstrate high performance. The robot achieves a high lift-to-weight ratio of 3.7, a low hovering voltage of 500 V, and a long lifetime that exceeds 2 million actuation cycles. With 20 s of hovering time, and position and attitude error smaller than 2.5 cm and 2°, respectively, the robot demonstrates the longest and best-performing flight among existing sub-gram aerial robots. This important milestone demonstrates that soft robots can outperform their state-of-the-art rigid counterparts, and it provides an important step toward realizing power autonomy in soft robotic flights.

Biomimetic Metal-Organic Framework Nanoparticles for Synergistic Combining of SDT-Chemotherapy Induce Pyroptosis in Gastric Cancer

Abstract: In recent years, sonodynamic therapy (SDT) has been widely developed for cancer research as a promising non-invasive therapeutic strategy. Here, we synthesized zeolitic imidazole frameworks-8 (ZIF-8) and utilized its properties to encapsulate hydrophobic Chlorin e6 (Ce6) and hydrophilic tirapazamine (TPZ) for a synergistic sonodynamic chemotherapy, which was also accompanied by the modification of cytomembrane of gastric cancer (GC) cells. Thus, we enabled the biomimetic property to achieve targeted delivery. Ce6-mediated SDT, in combination with ultrasound irradiation, could target the release of reactive oxygen species (ROS) to aggravate further hypoxia and activate TPZ. Combining these effects could induce the pyroptosis of GC cells and play the anti-tumor function, which could provide a potential therapeutic method for cancer therapy.

A comparative study based on serum SERS spectra in and on the coffee ring for high precision breast cancer detection

Abstract: Human blood contains a variety of biomolecules that are highly related to the occurrence, progression, and prognosis of diseases, including cancer. The development of rapid and accurate methods for the detection of these biomarkers with extremely low concentration is vital for improving cancer screening. Herein, a label-free surface-enhanced Raman scattering (SERS) technology was employed to detect human serum samples from healthy volunteers (n = 51) and breast cancer patients (n = 58) with the aim of exploring the differences in bio-components between them. Moreover, the influence of measurement location during SERS assay was evaluated due to the occurrence of “coffee-ring (CR)” effect associated with this work. Results showed that the SERS spectra obtained from the CR area can better reflect the overall biochemical information of serum samples and exhibited excellent diagnostic sensitivity (94.8%) and specificity (98%) for identifying breast cancer from healthy groups using principal component analysis and linear discriminant analysis (PCA-LDA) algorithm. This work showed a preliminary study of the serum SERS method for breast cancer detection, providing a potential rapid and accurate liquid biopsy strategy for clinical cancer screening.