Institution
Government Rajaji Hospital
Healthcare•Madurai, India•
About: Government Rajaji Hospital is a healthcare organization based out in Madurai, India. It is known for research contribution in the topics: Population & Tuberculosis. The organization has 193 authors who have published 116 publications receiving 1103 citations. The organization is also known as: Erskines Hospital.
Papers published on a yearly basis
Papers
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TL;DR: HLA-DRB1*1501 and DQB1*0601 predisposed to sputum positive pulmonary tuberculosis, and DPB1-04 was preventive and epistatic to this risk.
153 citations
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TL;DR: The release of bacterial and viral DNA elements in the circulation could play a major role leading to elevated circDNA levels in CVD patients, which could be either the cause or consequence of CVD incidence.
Abstract: Cardiovascular diseases (CVDs) are the leading cause of death worldwide. An expanding body of evidence supports the role of human microbiome in the establishment of CVDs and, this has gained much attention recently. This work was aimed to study the circulating human microbiome in CVD patients and healthy subjects. The levels of circulating cell free DNA (circDNA) was higher in CVD patients (n = 80) than in healthy controls (n = 40). More specifically, the relative levels of circulating bacterial DNA and the ratio of 16S rRNA/β-globin gene copy numbers were higher in the circulation of CVD patients than healthy individuals. In addition, we found a higher circulating microbial diversity in CVD patients (n = 3) in comparison to healthy individuals (n = 3) by deep shotgun sequencing. At the phylum level, we observed a dominance of Actinobacteria in CVD patients, followed by Proteobacteria, in contrast to that in healthy controls, where Proteobacteria was predominantly enriched, followed by Actinobacteria. The circulating virome in CVD patients was enriched with bacteriophages with a preponderance of Propionibacterium phages, followed by Pseudomonas phages and Rhizobium phages in contrast to that in healthy individuals, where a relatively greater abundance of eukaryotic viruses dominated by Lymphocystis virus (LCV) and Torque Teno viruses (TTV) was observed. Thus, the release of bacterial and viral DNA elements in the circulation could play a major role leading to elevated circDNA levels in CVD patients. The increased circDNA levels could be either the cause or consequence of CVD incidence, which needs to be explored further.
143 citations
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TL;DR: 4-month thrice-weekly regimens of gatifloxacin or moxiflOxacin with isoniazid, rifampicin and pyrazinamide, were inferior to standard 6-month treatment, in patients with newly diagnosed sputum positive pulmonary TB.
Abstract: Background
Shortening tuberculosis (TB) treatment duration is a research priority. This paper presents data from a prematurely terminated randomized clinical trial, of 4-month moxifloxacin or gatifloxacin regimens, in South India.
Methods
Newly diagnosed, sputum-positive HIV-negative pulmonary TB patients were randomly allocated to receive gatifloxacin or moxifloxacin, along with isoniazid and rifampicin for 4 months with pyrazinamide for first 2 months (G or M) or isoniazid and rifampicin for 6 months with ethambutol and pyrazinamide for first 2 months (C). All regimens were administered thrice-weekly. Clinical and bacteriological assessments were done monthly during treatment and for 24 months post-treatment. The Data and Safety Monitoring Board recommended termination of the trial due to high TB recurrence rates in the G and M regimens.
Results
Of 416 patients in intent-to-treat analysis, 6 (5%) of 124, 2 (2%) of 110 and 2 (2%) of 137 patients with drug-susceptible TB in the G, M and C arms respectively had unfavorable response at the end of treatment; during the next 24 months, 17 (15%) of 115, 11 (11%) of 104 and 8 (6%) of 132 patients respectively, had TB recurrence. Of 38 drug-resistant patients 1 of 8 and 3 of 26 in the G and C arms respectively had unfavourable response at the end of treatment; and TB recurrence occurred in 2 of 7 and 2 of 23 patients, respectively. The differences in TB recurrence rates between the G and C arms was statistically significant (p = 0.02). Gastro-intestinal symptoms occurred in 23%, 22% and 9% of patients in the G, M and C arms respectively, but most reactions were mild and manageable with symptomatic measures; 1% required regimen modification.
Conclusions
4-month thrice-weekly regimens of gatifloxacin or moxifloxacin with isoniazid, rifampicin and pyrazinamide, were inferior to standard 6-month treatment, in patients with newly diagnosed sputum positive pulmonary TB.
Trial Registration
Clinical Trials Registry of India CTRI/2012/10/003060
87 citations
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55 citations
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TL;DR: The results reveal that cardiac alpha2M could be a valuable marker for the diagnosis of myocardial infarcted diabetic patients and differentiating them from diabetic patients without myocardIAL infarction by sandwich ELISA.
39 citations
Authors
Showing all 193 results
Name | H-index | Papers | Citations |
---|---|---|---|
Shunmugiah Karutha Pandian | 40 | 227 | 5408 |
Natarajan Muthukumar | 23 | 72 | 1588 |
Andiappan Rathinavel | 11 | 19 | 709 |
Satish Chandraprakasam | 5 | 16 | 66 |
R. Gajendran | 4 | 7 | 34 |
Gurunathan J | 3 | 4 | 29 |
K. Rajaram | 3 | 3 | 69 |
G. Mathevan | 3 | 3 | 123 |
Jeyakumar Williams | 3 | 5 | 18 |
Kuppamuthu Ramakrishnan | 3 | 4 | 121 |
Sivakumar Elango | 3 | 3 | 22 |
Prabhakaran Rathinam | 3 | 4 | 49 |
K. Rajaram | 3 | 4 | 327 |
Lakshmikanthan Thayumanavan | 3 | 3 | 26 |
Athira Unnikrishnan | 3 | 7 | 46 |