Showing papers by "ICM Partners published in 1991"

NMR Delineation of Inner and Outer Protons from Paramagnetic Relaxation Perturbations in 1D and 2D Spectra of Peptides

Abstract: The use of soluble spin labels to filter out the cross-peaks of outer proton nuclei in 2D NMR spectra is proposed as a general method of obtaining structural information about complex molecules. Gramicidin S, a decapeptide of well defined and stable structure, has been used as a model system to correlate the paramagnetic effects observed in 1 D and 2D spectra and the peptide solution conformation. The method appears particularly suited to obtaining information about the hydrogen bonding of backbone amide protons.