Jan Kochanowski University

About: Jan Kochanowski University is a education organization based out in Kielce, Poland. It is known for research contribution in the topics: Population & Redshift survey. The organization has 1319 authors who have published 3979 publications receiving 41536 citations. The organization is also known as: Jan Kochanowski University in Kielce & Uniwersytet Jana Kochanowskiego w Kielcach.

The self-disproportionation of the enantiomers (SDE) of methyl n-pentyl sulfoxide via achiral, gravity-driven column chromatography: a case study.

Abstract: This work explores the self-disproportionation of enantiomers (SDE) of chiral sulfoxides via achiral, gravity-driven column chromatography using methyl n-pentyl sulfoxide as a case study. A major finding of this work is the remarkable persistence and high magnitude of the SDE for the analyte. Thus, it is the first case where SDE is observed even in the presence of MeOH in the mobile phase. The study demonstrated the practical preparation, in line with theory, of enantiomerically pure (>99.9% ee) samples of methyl n-pentyl sulfoxide starting from a sample of only modest ee (<35%). Remarkably, it was found that the order of elution was inverted, i.e. enantiomerically depleted fractions preceded later eluting enantiomerically enriched ones, when the stationary phase was changed from silica gel to aluminum oxide. To the best of our knowledge, this is the first occurrence of inverted SDE behavior due solely to a change in the stationary phase. Aberrant SDE behavior was observed in that the ee did not always fall continuously during the progression of the chromatography, and this was attributed to the complexity of the system at hand which cannot be described in simple terms such as the formation only of homo- and heterochiral dimers based on a single interaction. The results nevertheless suggest that all compounds with a chiral sulfoxide moiety in their structure are likely to exhibit the SDE phenomenon and thus this work constitutes the first example of SDE predictability. Moreover, it could well be that optical purification based on the SDE phenomenon is a simple, convenient, and inexpensive method for the optical purification of this class of compounds with a high degree of proficiency.

Azimuthally sensitive femtoscopy in hydrodynamics with statistical hadronization from the BNL Relativistic Heavy Ion Collider to the CERN Large Hadron Collider

Abstract: Azimuthally sensitive femtoscopy for heavy-ion collisions at the Relativistic Heavy Ion Collider (RHIC) and Large Hadron Collider (LHC) is explored within the approach consisting of the hydrodynamics of perfect fluid followed by statistical hadronization. It is found that for the RHIC initial conditions, employing the Gaussian shape of the initial energy density, the very same framework that reproduces the standard soft observables [including the transverse-momentum spectra, the elliptic flow, and the azimuthally averaged Hanbury-Brown-Twiss (HBT) radii] leads to a proper description of the azimuthally sensitive femtoscopic observables; we find that the azimuthal variation of the side and out HBT radii as well as out-side cross term are very well reproduced for all centralities. Concerning the dependence of the femtoscopic parameters on k{sub T} we find that it is very well reproduced. The model is then extrapolated to the LHC energy. We predict the overall moderate growth of the HBT radii and the decrease of their azimuthal oscillations. Such effects are naturally caused by longer evolution times. In addition, we discuss in detail the space-time patterns of particle emission. We show that they are quite complex and argue that the overall shape seen by the femtoscopic methods cannot be easily disentangledmore » on the basis of simple-minded arguments.« less

Factors associated with gestational weight gain: a cross-sectional survey.

Abstract: The aim of this study was to describe the dietary patterns in pregnant women and determine the association between diet factors, pre-pregnancy body mass index, socio-demographic characteristics and gestational weight gain. The analysis was conducted on a group of 458 women. Cut-off values of gestational weight gain adequacy were based on recommendations published by the US Institute of Medicine and were body mass index-specific. Logistic regression analysis was used to assess the risk of the occurrence of inadequate or excessive gestational weight gain. Dietary patterns were identified by factor analysis. Three dietary patterns characteristic of pregnant women in Poland were identified: ‘unhealthy’, ‘varied’ and ‘prudent’. The factor associated with increased risk of inadequate gestational weight gain was being underweight pre-pregnancy (OR = 2.61; p = 0.018). The factor associated with increased risk of excessive weight gain were being overweight or obese pre-pregnancy (OR = 7.00; p = 0.031) and quitting smoking (OR = 7.32; p = 0.019). The risk of excessive weight gain was decreased by being underweight pre-pregnancy (OR = 0.20; p = 0.041), being in the third or subsequent pregnancy compared to being in the first (OR = 0.37; p = 0.018), and having a high adherence to a prudent dietary pattern (OR = 0.47; p = 0.033). Women who were overweight or obese pre-pregnancy and those who quit smoking at the beginning of pregnancy should be provided with dietary guidance to prevent excessive gestational weight gain.

Antitumor Activity of Pt(II), Ru(III) and Cu(II) Complexes.

Abstract: Metal complexes are currently potential therapeutic compounds. The acquisition of resistance by cancer cells or the effective elimination of cancer-affected cells necessitates a constant search for chemical compounds with specific biological activities. One alternative option is the transition metal complexes having potential as antitumor agents. Here, we present the current knowledge about the application of transition metal complexes bearing nickel(II), cobalt(II), copper(II), ruthenium(III), and ruthenium(IV). The cytotoxic properties of the above complexes causing apoptosis, autophagy, DNA damage, and cell cycle inhibition are described in this review.