Showing papers by "John Radcliffe Hospital published in 1976"
TL;DR: Methyldopa is safe to use for the treatment of hypertension in pregnancy in the context of close medical and obstetric supervision and has no effect on fetal growth in utero.
261 citations
TL;DR: Findings suggest that, in terms of fetal health, changes in renal handling of urate may be a more important feature of pre-eclampsia than the hypertension.
259 citations
TL;DR: There was a significant decrease in the concentration of PGE and PGF in the plasma of lambs within 12 h after birth compared to the levels found in the same animals as fetuses a few hours previously.
147 citations
TL;DR: Preliminary observations suggest a new treatment for a common gynaecological problem and could imply that prostaglandins are involved in the aetiology of excessive menstrual blood-loss in patients with menorrhagia.
142 citations
TL;DR: The amount of loss, the percentage of women losing more than 80 ml, the decline in haemoglobin concentration, and the incidence of anaemia during the 12 cycles following insertion were all greater among users of the Lippes Loop than of the Copper 7 with generally intermediate values for Dalkon Shield users.
102 citations
TL;DR: A high turnover of prostaglandins in the chorion is suggested, and its importance as a source of prostglandins found in amniotic fluid is discussed.
89 citations
TL;DR: The possibility that prostaglandins may be an essential factor in the stimulation of corticosteroid production in the foetus is examined and a very rapid increase in foetal corticosterone production is reported during PGES infusion into the common carotoid artery offoetal lambs.
Abstract: MATURATION of the foetal hypothalamo-hypophyseal-adrenal axis appears to be involved in the initiation of parturition in several species1,2, but the limiting determinant of this maturational process has not yet been identified. In sheep, an increase in the plasma cortisol concentration of the foetus has been observed before parturition3,4 but it has been demonstrated that this increase is not preceded by an elevation in plasma ACTH5. It has been suggested that there is a maturation of the foetal adrenal responsiveness to ACTH stimulation6,7 and perhaps activation of those enzymes specifically associated with cortisol production8. Recently we have shown that a primary prostaglandin, prostaglandin E2 (PGE2), is present in the plasma of the foetal lamb and that its concentration increases during late pregnancy9. Here we examine the possibility that prostaglandins may be an essential factor in the stimulation of corticosteroid production in the foetus and report a very rapid increase in foetal corticosteroids during PGES infusion into the common carotoid artery of foetal lambs.
80 citations
TL;DR: Menstrual blood loss was measured objectively in 25 women for up to three months before and for six to twelve months after tubal ligation and made no significant difference to menstrual blood loss.
59 citations
TL;DR: It is suggested that uterine prostaglandin F production under these conditions may be assessed by measuring peripheral venous 13,14-dihydro-15-keto-prostagland in F, thereby avoiding the need for chronic utero-ovarian venous catheters.
50 citations
TL;DR: This technique significantly reduced individual patient care and minimized the potential risk of intrauterine sepsis associated with extra‐amniotic techniques requiring repeated or continuous PG administration.
34 citations
TL;DR: The results indicate that the PGDH content of the human placenta does not change markedly with the onset or during the process of labour, and the length of either spontaneous or oxytocin‐induced labour was not influenced by the PG DH content.
TL;DR: In multiple births, the first-born of triplets and quadruplets had higher L/S ratios than those subsequently born, which may indicate a link between fetal lung maturation and the onset of labour.
TL;DR: Plasminogen activators in the endometrium before and after insertion of an intrauterine contraceptive device (IUCD) were studied; an increase in the concentration was found following IUCD insertion in 16 of the 20 women.
TL;DR: The maximum secretion of estradiol and the pre-ovulatory LH peak occurred during the period of elevated PGF concentrations in the utero-ovarian veins, suggesting the possible importance of endogenous PGF production at this time is discussed.
TL;DR: The findings suggest that the excessive menstrual bleeding which occurs with the IUCD may be due to enhancement of fibrinolytic activity in the endometrium which can be modified by fibralelytic inhibitors such as epsilon aminocaproic acid.
TL;DR: The obstetric management and outcome of normal patients presenting to two obstetric teams working in the Cardiff Maternity Hospital are compared over a five‐year period.
TL;DR: This study suggests that patients who had chosen to have extradural analgesia may have been more anxious before labour than the other patients but continuous, extradural morphine suppressed to some extent the percentage increase in mean cortisol levels found during labour in patients given parenteral analgesia.
TL;DR: The management and outcome of labour when the breech presents is not adversely affected by the provision of extradural analgesia, and the length of both first and second stages of labour in multiparae was prolonged in the extradition group, but not markedly so.
TL;DR: It is suggested that prostaglandin metabolism in placenta and chorion does not markedly decrease with the onset and during the process of labor.
TL;DR: In this paper, five patients with primary infertility and secondary amenorrhea who did not respond to clomiphene with a gonadotropin or estrogen surge were treated with 500 μg of luteinizing hormone, follicle-stimulating hormone-releasing hormone (LH-RH), self-administered subcutaneously every 8 hours for 14 days.
TL;DR: Studies on the milk intake at 2 months of babies who were small-for-dates (SFD) and large- for- dates (LFD) at birth revealed that both classes of infant regulate their intake in accordance with a number of clearly defined measures.
Abstract: SummaryStudies on the milk intake at 2 months of babies who were small-for-dates (SFD) and large-for-dates (LFD) at birth revealed that both classes of infant regulate their intake in accordance with a number of clearly defined measures. Milk intake per unit body weight per day at 2 months related not only to weight but also to weight-for-length and head-for-weight indices at 2 months in SFD infants. Proportionality changes between 2 and 12 months showed shifts which related to the birth-weight group, and to milk intake at 2 months within that group, in these infants. LFD infants showed a different pattern. Rather than changing their proportions they maintained them virtually from birth to 12 months. They demonstrated the phenomenon the authors have called ‘latitude’. This latitude was evident in their pattern of weight change immediately after birth, as well as in their milk intake at 2 months and their increase in size during the first year of life. SFD infants have much less latitude from the moment of...
TL;DR: Evidence leading to the suggestion that progesterone secretion by the CL during the mid-luteal phase is influenced by prostaglandin production in different parts of the uterus is discussed.
TL;DR: It is suggested that the measurement of red cell DPG in the third trimester of pregnancy may prove to be a useful parameter of placental oxygenation.
TL;DR: Echis Carinatus venom contains both an activator of factor X and a prothrombin activator, which have been separated by column chromatography of the crude venom on DEAE cellulose.
TL;DR: A case‐control study showed that women who had previously had an infant with anencephaly or spina bifida did not have raised serum alpha‐fetoprotein (AFP) levels in subsequent unaffected pregnancies, and the value of a serum AFP determination in such women is discussed.
TL;DR: It is concluded that abortion can be induced with a single extra-amniotic injection of 1 mg of 15(S)-15 methyl PGF2alpha in viscous medium in a large percentage of patients but that the incidence of side effects is high.
TL;DR: The significance of these findings is discussed in relation to cervical rupture and cervico–vaginal fistulae that have been reported following second trimester abortion induced with prostaglandins.
TL;DR: It appears that the gonadotrophin response to a single injection of LH‐RH in the majority of patients with secondary amenorrhoea of unknown origin is too variable to be of use either as a diagnostic or prognostic tool.
TL;DR: The development of a terminal-labelling microcytotoxicity assay is described in which target cells (fetal fibroblasts) were labelled with 125I-iododeoxyuridine after effector cells had been incubated with them for 24 h.
TL;DR: The radiological findings in the four neonates investigated contributed significantly to the management of their illnesses and helped define the cause of their oliguria.