Showing papers by "Pharmaceutical Product Development published in 1963"

TL;DR: In this paper, the C∙4 epimerization of tetracycline has been shown to follow the kinetics of a first-order reversible reaction, and an Arrhenius plot indicated that the apparent energy of activation for the C ∙4 e ectimerization at pH 4.0 and 0.10 molar phosphate buffer was approximately 20 kilo-calories/grammole.

TL;DR: Several 21-hydroxylated steroids have been phosphorylaced directly and under very mild conditions with β-cyanoethyl phosphate in the presence of N,N'-dicyclohexylcarbodiimide.