Showing papers in "Journal of Pharmaceutical Sciences in 1963"

TL;DR: The analyses suggest that for the latter system the time required to release 50% of the drug would normally be expected to be approximately 10 per cent of that required to dissolve the last trace of the solid drug phase in the center of the pellet.

TL;DR: Nelson ( 2 ) derived Eq.

TL;DR: The results suggest that the tendency of many drugs to form such adducts provide pharmaceutical investigators a powerful tool in effecting rapid dissolution of highly insoluble substances.

TL;DR: The thermodynamic relationships involving polymorphism and solubility were examined in some detail and applied to experimental results with the methylprednisolone system and indicate that much more energetic crystal forms are probable.

TL;DR: In this article, the dissolution rate enhancing effect of sodium lauryl sulfate (in the case of conventional tablets) is not due to any modification of microenvironmental pH or solubilization by micelles, but rather to the better penetration of solvent into tablets and their component granules and the resulting greater availability of drug surface.

TL;DR: An equation is derived to describe the dissolution rate of a particle with time in a diffusion-controlled dissolution process that is applied to a hypothetical powder whose particles are approximately log-normally distributed.

TL;DR: The data seemed to indicate two mechanisms for the hydrolysis of the carbamates: that initiated by an hydroxyl ion attachment on the central carbon atom followed by a carbamate ion intermediate, and that involving direct ionization of an amide hydrogen followed by formation of an isocyanate intermediate.

TL;DR: Dissolution data for sized fractions of three different compounds were obtained using the method of Niebergall and Goyan using a rate expression assuming that the thickness of the diffusion layer was proportional to the square root of the mean volume diameter.

TL;DR: It is shown that the ratio of dissolution rates of two or more drugs, when rates are determined by the rotating disk method, is independent of stirring rate, provided this proportionality or a similar more general relationship applies.

TL;DR: By means of the solubility method of analysis, the Schardinger dextrins were shown to interact in aqueous solution with benzoic acid derivatives and it is postulated that both hydrogen bonding and inclusion formation are responsible for the main interaction observed.

TL;DR: Comparison of the isothermal slopes of the interactions shows that the largest molecules show the smallest slopes and therefore the smallest degree of interaction with the cyclodextrins.

TL;DR: A 5-day old, 15 percent (v/v) spearmint cell inoculum in a dual-carboy system containing modified T-medium with 2,4-dichlorophenoxyacetic acid (0.5 p.p.m.), Dow Corning-B antifoam, and bacitracin was suggested for good cell suspension growth as mentioned in this paper.

TL;DR: It was found that spray-dried lactose produced harder, less friable tablets which, however, were more susceptible to color development following storage at elevated temperatures.

TL;DR: The reasonably good agreement between experiment and theory suggests that the rate-determining step, in this instance, is diffusion of the drug in the aqueous phase.

TL;DR: A new sustained-release micropellet was prepared which takes advantage of the relationship of gelatin solubility to the hardness of the gelatin caused by formalin treatment to be produced more easily than the coated micropELlet employed in the usual sustained- release dosage forms.

TL;DR: In this paper, the C∙4 epimerization of tetracycline has been shown to follow the kinetics of a first-order reversible reaction, and an Arrhenius plot indicated that the apparent energy of activation for the C ∙4 e ectimerization at pH 4.0 and 0.10 molar phosphate buffer was approximately 20 kilo-calories/grammole.

TL;DR: Rates of aggregation of initially monodispersed 1.83- μ polystyrene latex particles in various electrolyte solutions at different electrolyte concentrations have been studied and theoretical calculations of the "bimolecular" rate constants were carried out.

TL;DR: The analytical method employed is based on the reduction of a portion of the nitrate of each ester to the nitrite upon alkaline hydrolysis, and the color spectrophotometrically was determined by diazotization of sulfanilic acid and subsequent coupling with N-(l-naphthyl)-ethylenediamine.

TL;DR: A preliminary study of the roots of Thalictrum dasycarpum Fisch and Lall from Wisconsin yielded magnoflorine and a new alkaloid, thalicarpine as discussed by the authors.

TL;DR: Dissolution rate increased with decreasing granule size, but not strictly proportionally to the corresponding increase in the apparent surface area of the granules, which was probably due to fracturing of the harder granules into smaller particles with greater specific surface area.

TL;DR: There seems to be a linear relationship between solubility, surface tension, and viscosity of the lipids in carbon dioxide, krypton, and xenon.

TL;DR: The results of the study revealed that under the experimental conditions used in this study a number of the tubings will produce tissue response while others will not.

TL;DR: In this paper, an automatic recording apparatus was developed to follow the process of dissolution, which was equipped with various speed chart drive motors that permitted readings to be taken from the graph at intervals down to 0.375sec.

TL;DR: In post-absorptive and post-equilibrative times the elimination process was found to be first order with a mean half-life of 1.95 hours, indicating that poor correlation exists between pharmacological activity and body level of acetaminophen, even though a kinetic relationship may exist between these quantities.

TL;DR: Although morphine may be gas chromatographed as such, its phenolic properties cause adsorption which produces tailing and makes quantitative work impossible, which was overcome by converting morphine to its trimethylsilyl ether which gave a symmetrical elution peak suitable for quantitative estimation.

TL;DR: Effect of hydrogen ion concentration on the oxidation of sulfurous acid salts was studied in detail and the results described in terms of a theoretically derived equation.

TL;DR: The pH rate profile of the rate of disappearance of ascorbic acid from aqueous solution under anaerobic conditions has been determined at 96° and shows buffer dependency but relatively small ionic strength effect.

TL;DR: In this paper, a method for determining the pressure transmitted to the die wall during tablet compression is described, which involves strain-gauge measurement of die expansion and the relation of this to the transmitted pressure.