Showing papers by "Royal London Hospital published in 2022"
TL;DR: In this paper , the authors analyzed new data from two randomised controlled phase 3 trials done in a multi-arm, multistage platform protocol to assess the efficacy of adding abiraterone and prednisolone alone or with enzalutamide to ADT.
121 citations
TL;DR: The Post-hospitalisation COVID-19 study (PHOSP-COVID) as mentioned in this paper is a prospective, longitudinal cohort study recruiting adults (aged ≥18 years) discharged from hospital with COVID19 across the UK.
118 citations
TL;DR: In this paper , the authors examined the cellular and molecular sequelae of TBI in fresh brain samples and related these to clinical outcomes, which enabled classification of this heterogeneous patient population into various injury severity categories according to the Yip, Hasan and Uff (YHU) grading system.
Abstract: Traumatic brain injury (TBI) is an extremely complex disease and current systems classifying TBI as mild, moderate, and severe often fail to capture this complexity. Neuroimaging cannot resolve the cellular and molecular changes due to lack of resolution, and post-mortem tissue examination may not adequately represent acute disease. Therefore, we examined the cellular and molecular sequelae of TBI in fresh brain samples and related these to clinical outcomes. Brain biopsies, obtained shortly after injury from 25 living adult patients suffering severe TBI, underwent immunohistochemical analysis. There were no adverse events. Immunostaining revealed various qualitative cellular and biomolecular changes relating to neuronal injury, dendritic injury, neurovascular injury, and neuroinflammation, which we classified into 4 subgroups for each injury type using the newly devised Yip, Hasan and Uff (YHU) grading system. Based on the Glasgow Outcome Scale-Extended, a total YHU grade of ≤8 or ≥11 had a favourable and unfavourable outcome, respectively. Biomolecular changes observed in fresh brain samples enabled classification of this heterogeneous patient population into various injury severity categories based on the cellular and molecular pathophysiology according to the YHU grading system, which correlated with outcome. This is the first study investigating the acute biomolecular response to TBI.
3 citations
15 Sep 2022
TL;DR: In the interim since this paper was accepted for publication, new governmental regulations, pertinent to the topic, have been approved for implementation as mentioned in this paper and the reader is thus directed to this online addendum for additional relevant information: https://links.lww.com/AA/E44
Abstract: ADDENDUM: Please note that in the interim since this paper was accepted for publication, new governmental regulations, pertinent to the topic, have been approved for implementation. The reader is thus directed to this online addendum for additional relevant information: https://links.lww.com/AA/E44
2 citations
01 May 2022
TL;DR: Damiete Harry et al. as discussed by the authors conducted a study with regional core surgical and foundation trainees to ascertain their confidence level and knowledge surrounding catheterisation and exchange of suprapubic catheters.
Abstract: You have accessJournal of UrologyCME1 May 2022V05-09 VIRTUAL LEARNING AND COLLABORATIVE WORKING IN A PANDEMIC - HOW TO CHANGE A SUPRAPUBIC CATHETER Damiete Harry Damiete HarryDamiete Harry More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002579.09AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: With the centralisation of urological services in the UK it is not always possible to have straight forward procedures such as exchange of suprapubic catheters (SPC) performed by a member of the urology team. Moreover, during the height of the COVID pandemic a significant number of urology junior doctors were redeployed to ITU, thus not available for changes of SPCs on the ward. METHODS: A questionnaire-based study of regional core surgical and foundation trainees was performed to ascertain their confidence level and knowledge surrounding catheterisation and exchange of SPCs. The results of this study formed the basis for the production of a YouTube video on how to change an SPC. RESULTS: 45.8% of all core surgical trainees surveyed had never changed a suprapubic catheter; 35.4% of all core surgical trainees felt this should only be performed by a member of the urology team. 86.6% foundation trainees had never changed a suprapubic catheter; 56.7% of all foundation trainees felt this should only be performed by a member of the urology team. After watching the video they were seen to have an increase in confidence with the post teaching feedback showing only 12.2% of those studied stating only the urology department should perform suprapubic catheter changes. CONCLUSIONS: The training video was created and it has been found that the confidence of the junior doctors was increased. This video has now been incorporated in the regional induction curriculum for foundation trainees. It is a useful tool for distanced learning and adequate for giving colleagues the confidence to perform this simple procedure. Source of Funding: Self funded © 2022 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 207Issue Supplement 5May 2022Page: e519 Advertisement Copyright & Permissions© 2022 by American Urological Association Education and Research, Inc.MetricsAuthor Information Damiete Harry More articles by this author Expand All Advertisement PDF downloadLoading ...
TL;DR: In this article , a two-part, randomised, double-blind, placebo-controlled, phase 1b trial was conducted to evaluate emraclidine as a once-daily treatment for schizophrenia.
TL;DR: In this article , a 9-year-old patient with a right-sided supracondylar fracture of the humerus was treated for posttraumatic recurrent posterior pediatric elbow instability in a patient with joint hypermobility.
Abstract: Despite growing concordance of opinion in the adult setting, pediatric elbow instability and its management are poorly represented in the literature due to its low prevalence and often unique circumstances. The authors present a case of posttraumatic recurrent posterior pediatric elbow instability in a patient with joint hypermobility. Our patient, a 9-year-old girl, sustained a right-sided supracondylar fracture of the humerus in April 2019. Having been managed operatively, the elbow remained unstable and dislocated posteriorly in extension. Definitive surgical management was designed to provide a stable functional elbow. The principle of the surgery was to create a checkrein of tissue, not changing in length in extension and flexion, and to prevent further posterior elbow instability. A 3 mm slip of the central triceps tendon was dissected, leaving its attachment to the olecranon tip. Gracilis allograft was sutured to the strip of the triceps tendon to increase the tensile properties of the native tendon graft using a braided nonabsorbable suture. The tendon construct was then passed through a window made in the olecranon fossa and a transosseous tunnel in the ulna from the coronoid tip to the dorsal cortex. The tendon was tensioned and secured to the radial-dorsal aspect of the ulna with a nonabsorbable suture anchor in 90 degrees of flexion. At one year follow-up, the patient has a stable and pain-free elbow joint with no functional limitations.
01 Jan 2022
TL;DR: In this article , the feasibility and safety of high-frequency jet ventilation (HFJV) for percutaneous image-guided ablation (IGA) procedures is described. But, the authors do not discuss the safety of the technique in routine use.
Abstract: High-frequency jet ventilation (HFJV) can reduce organ movement that otherwise complicates percutaneous image-guided ablation (IGA) procedures. This study describes feasibility and safety of the technique in routine use. We describe our method for the use of HFJV and present 169 consecutive cases, including IGA of tumors of the lung, liver, kidney, and pancreas. Intended oncological treatment was delivered in all cases and HFJV used for the duration of treatment in all except one case. We describe the characteristics of patients, procedures, and adverse events. It is feasible to use HFJV as the routine standard of care for IGA.