Showing papers by "Saint Francis University published in 1987"
TL;DR: It is confirmed that ganglioglioma is a distinct histological entity, anatomically localized, with characteristic clinical and radiological findings and long term survival and the definitive role of follow-up radiotherapy for this tumor needs further study.
Abstract: Gangliogliomas are rare benign tumors of the central nervous system containing neoplastic ganglion and low grade glial cells. In studying 10 surgically treated cases, we evaluated the clinical, pathological, radiological, and immunocytochemical features, with follow-up. Ranging from 18 to 58 years i
185 citations
TL;DR: TNF alpha stimulates calvarial DNA synthesis which causes an increased number of collagen-synthesizing cells, but TNF alpha has a direct inhibitory effect on osteoblastic function.
Abstract: Tumor necrosis factor (TNF) was studied for its effects on bone formation in cultured rat calvariae TNF alpha at 100-100,000 U/ml stimulated [3H]thymidine incorporation into DNA, an effect that appeared after 24 h of treatment and lasted 96 h Transient (24-h) treatment with TNF alpha increased [3H]proline incorporation into type I collagen 24-72 h after the factor was removed; this effect was DNA synthesis dependent and blocked by hydroxyurea Transient treatment with TNF alpha also increased alkaline phosphatase activity In contrast, continuous treatment with TNF alpha for 48-96 h caused a marked inhibition on [3H]proline incorporation into type I collagen and alkaline phosphatase activity TNF alpha caused a small increase in collagen degradation Lymphotoxin had similar effects to those of TNF alpha In conclusion, TNF alpha stimulates calvarial DNA synthesis which causes an increased number of collagen-synthesizing cells, but TNF alpha has a direct inhibitory effect on osteoblastic function
137 citations
TL;DR: Findings reinforce a role of TGF‐β as an anabolic bone growth regulator, and suggest that its function may be modified by other local or systemic agents that can also affect bone cells.
Abstract: Type beta transforming growth factor (TGF-beta) is found in large amounts in bone tissue, and is a potent mitogen for osteoblast-enriched cell cultures obtained from fetal rat parietal bone. Because other local and systemic factors may be presented to bone cells simultaneously with TGF-beta, it is important to understand the effects of this complex growth regulator in such circumstances. Unlike the effects observed in many tissue systems, TGF-beta does not invariably inhibit the mitogenic response of bone cells to other growth promoters. In contrast, other factors such as epidermal growth factor (EGF), basic fibroblast growth factor (bFGF), and type alpha tumor necrosis factor (TNF-alpha) limit the response of osteoblastic bone cells to TGF-beta. TGF-beta is a much weaker mitogen for fibroblastic cells obtained from fetal rat bone, whereas fetal bovine serum, EGF, bFGF, and TNF-alpha are more potent stimulators. In addition, TGF-beta does not significantly impair the response of the fibroblastic bone cell...
63 citations
TL;DR: Multivariate analysis of the data showed that better metabolic control was most strongly associated with compliance with scheduled appointments, and other variables, possibly including several psychosocial variables, need to be assessed for their contribution to metabolic control.
Abstract: We conducted a cross-sectional study to assess the association of various demographic and medical-care variables with metabolic outcomes in non-insulin-dependent diabetic subjects. The study population was representative of the diagnosed care-seeking diabetic population of a defined geographic community on the Navajo reservation in Arizona. The dependent variable metabolic control was measured as the mean of all random plasma glucose values obtained only at scheduled diabetes clinic visits over 2yr. Multivariate analysis of the data showed that better metabolic control was most strongly associated with compliance with scheduled appointments. Mode of treatment was also associated with metabolic control. Other variables tested, including source of care, age, sex, duration of diabetes, presence of complications, and weight change, were not associated with metabolic control. The strongest analysis of covariance model with demographic and medical-care variables accounted for 39% of the variance in metabolic control. The analysis suggests that other variables, possibly including several psychosocial variables, need to be assessed for their contribution to metabolic control.
24 citations
TL;DR: Although thallium uptake is frequently reduced in nonsalvaged myocardium, tracer uptake can be normal or increased if perfusion has been completely restored, however, an increased clearance rate from the reperfused zone compared to the normal zone is a reliable indicator of nonsalVaged my Cardium, despite normal initial thallia uptake.
21 citations
Journal Article•
TL;DR: A fifth case of bilateral interhemispheric subdural hematoma is reported, usually associated with severe trauma or extenuating circumstances (anticoagulation, ventriculoperitoneal shunt).
Abstract: Bilateral interhemispheric subdural hematoma is a rare posttraumatic lesion that has only received mention in the radiologic literature [1], and a mere four cases have been acknowledged in the medical literature [1, 2]. It is usually associated with severe trauma or extenuating circumstances (anticoagulation, ventriculoperitoneal shunt). We report a fifth case of bilateral interhemispheric subdural hematoma.
12 citations
TL;DR: This article presents a comprehensive review of neuromuscular blocking agents and their uses in the emergency department, divided into depolarizing relaxants and nondepolarizing Relaxants.
Abstract: This article presents a comprehensive review of neuromuscular blocking agents and their uses in the emergency department. These medicines are divided into two categories: depolarizing relaxants (including succinylcholine and decamethonium) and nondepolarizing relaxants (including d-tubocurarine, pancuronium, atracurium, and vecuronium). Also reviewed are pharmaco-kinetics, toxicity, and principal applications of these important agents.
5 citations
TL;DR: Rural hospitals can devise and apply high-energy feeding regimens and obtain results as good as those obtained in specialist units, and these figures show that the efficacy of high- energy feeding regimen in nutritional resuscitation of severely malnourished children is established.
Abstract: Over a 1 year period 472 patients with protein-energy malnutrition were admitted into a rural hospital in the Katete district of Eastern Zambia. 290 ranged in age from 1 year to 2 years and 11 months 275 of these children were put on high energy feeding regimens and their nutritional progress and weight gain were recorded. Routine investigations included hemoglobin chest X-ray Mantoux test (10 TU) and urine and stool microscopy. Initial treatment was designed to keep the child warm dry and free from hypoglycemia. Anorexia was so common that nasogastric feeding was used on almost all children. Initial feeding was with a glucose water solution then skimmed milk progressing after 3 days to a protein-calorie mixture made from skimmed milk powder vegetable oil and sugar. Children were fed 150 kcal/kg/day and protein 4g/kg/day. The weight gain achieved for the entire series was 8.93 g/kg/day. For the different diagnostic categories the weight gains were: 12.11 g/kg/day for children with marasmic kwashiorkor; 10.01 g/kg/day for children with kwashiorkor; 7.49 g/kg/day for children with marasmus; and 6.39 g/kg/day for children who were underweight. The hospital case fatality was 4.4%. The length of stay in hospital was determined case by case taking into account the rate of weight gain and the estimated ability of the mother to continue a satisfactory feeding regimen at home. The study shows that a simple high-energy feeding regimen applied under service conditions in a rural hospital with free use of nasogastric feeding accurate daily weighings and therapeutic trials of broad spectrum antibiotics and antituberculous treatment can give results as good as those obtained in specialist units.
5 citations
TL;DR: A review of the associated problems is presented along with suggested solutions to aid the nurse in choosing a therapeutic method for intravenous drug administration.
Abstract: Most decisions regarding the methods used for intravenous drug delivery are made by nurses. For this reason, neonatal nurses must recognize the unique problems associated with drug delivery to the low birth weight infant. A review of the associated problems is presented along with suggested solutions to aid the nurse in choosing a therapeutic method for intravenous drug administration.
5 citations
01 Jan 1987
TL;DR: Endometrial biopsies taken after several months of treatment indicated inactive endometrium or variable stages of proliferation and potential drawbacks of long term treatment could be related to the persistent state of decreased and unopposed estrogens.
Abstract: Continuous LHRH infusion in normal women leads to pituitary and gonadal desensitization [1]. Once daily intranasal administration of potent LHRH agonists consistently blocks ovulation and prevents progesterone secretion [2–5]. However under repetitive administration of LHRH agonist and pituitary down-regulation the inhibition of follicular activity is variable and there is a high incidence of oligomenorrhea and amenorrhea [3–5]. Endometrial biopsies taken after several months of treatment indicated inactive endometrium or variable stages of proliferation [6,7]. Potential drawbacks of long term treatment could be related to the persistent state of decreased and unopposed estrogens.
3 citations
TL;DR: Doppler echocardiography appears to be a useful noninvasive imaging modality in the evaluation of patients with cardiac trauma because of the ability to detect the presence of a ventricular septal defect.
Abstract: A case of traumatic ventricular septal defect diagnosed by Doppler echocardiography is described. The characteristic pulsed Doppler findings of a left-to-right shunt were recorded and the two-dimensional echocardiographic images of septal interruption were shown. Combined Doppler and two-dimensional echocardiography enhances the ability to detect the presence of a ventricular septal defect. Doppler echocardiography appears to be a useful noninvasive imaging modality in the evaluation of patients with cardiac trauma.
TL;DR: The full semicircular curve holds the tip off the lateral wall of the right ventricular outflow tract facilitating its passage, reducing arrhythmias, and reducing the chance of perforation.
Abstract: Catheters with a distal curve consisting of a half circle of 7.5 cm diameter have been found to markedly facilitate pulmonary artery catheterization from either arm in adults. The full semicircular curve holds the tip off the lateral wall of the right ventricular outflow tract facilitating its passage, reducing arrhythmias, and reducing the chance of perforation. The curve was factory-formed into both end-hole type catheters for pressures, pulmonary wedging, and blood sampling and formed into side-hole catheters with a closed-end, as the NIH, for pulmonary angiograms. In 179 of 182 procedures, it was observed clearly to facilitate, to make more gentle, and to speed pulmonary artery catheterization as compared to catheters with lesser curves.