Institution
Shanxi College of Traditional Chinese Medicine
About: Shanxi College of Traditional Chinese Medicine is a based out in . It is known for research contribution in the topics: Acupuncture & Centrosome. The organization has 91 authors who have published 76 publications receiving 592 citations.
Topics: Acupuncture, Centrosome, Apoptosis, Clematis, Ischemia
Papers published on a yearly basis
Papers
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TL;DR: The observed results in present study suggest that osthole exhibits therapeutic potential for vascular dementia, which is most likely related, at least in part, to its antioxidation and anti-apoptotic actions.
91 citations
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TL;DR: The prevalence of PMS/PMDD and the frequency and severity of the symptoms have their own characteristics in Chinese women.
77 citations
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TL;DR: In vivo study demonstrated that injection of quercetin in A549 tumor‐bearing mice effectively suppressed cancer growth and the phosphorylation of histone 3 in tumor tissues was also decreased after quercetus treatment.
Abstract: aurora B kinase is highly expressed in several cancer cells and promotes tumorigenesis and progression, and therefore, it is an important target for drug to treat tumors. Quercetin was identified to be an antitumor agent. Herein, we report for the first time that quercetin inhibited aurora B activities by directly binding with aurora B in vitro and in vivo. Ex vivo studies showed that quercetin inhibited aurora B activities in JB6 Cl41 cells and A549 lung cancer cells. Moreover, knockdown of aurora B in A549 cells decreased their sensitivities to quercetin. In vivo study demonstrated that injection of quercetin in A549 tumor-bearing mice effectively suppressed cancer growth. The phosphorylation of histone 3 in tumor tissues was also decreased after quercetin treatment. In short, quercetin can suppress growth of lung cancer cells as an aurora B inhibitor both in vitro and in vivo.
53 citations
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TL;DR: Novel experimental evidences are provided supporting that VC or/and VE could reduce p,p′-DDT-induced cytotoxicity of HL-7702 cells via the ROS-mediated mitochondrial pathway and NF-κB/FasL pathway.
Abstract: Dichlorodiphenoxytrichloroethane (DDT) is a known persistent organic pollutant and liver damage toxicant. However, there has been little emphasis on the mechanism underlying liver damage toxicity of DDT and the relevant effective inhibitors. Hence, the present study was conducted to explore the protective effects of vitamin C (VC) and vitamin E (VE) on the cytotoxicity of DDT in HL-7702 cells and elaborate the specific molecular mechanisms. The results demonstrated that p,p′-DDT exposure at over 10 µM depleted cell viability of HL-7702 cells and led to cell apoptotic. p,p′-DDT treatment elevated the level of reactive oxygen species (ROS) generation, induced mitochondrial membrane potential, and released cytochrome c into the cytosol, with subsequent elevations of Bax and p53, along with suppression of Bcl-2. In addition, the activations of caspase-3 and -8 were triggered. Furthermore, p,p′-DDT promoted the expressions of NF-κB and FasL. When the cells were exposed to the NF-κB inhibitor (PDTC), the up-regulated expression of FasL was attenuated. Strikingly, these alterations caused by DDT treatment were prevented or reversed by the addition of VC or VE, and the protective effects of co-treatment with VC and VE were higher than the single supplement with p,p′-DDT. Taken together, these findings provide novel experimental evidences supporting that VC or/and VE could reduce p,p′-DDT-induced cytotoxicity of HL-7702 cells via the ROS-mediated mitochondrial pathway and NF-κB/FasL pathway.
45 citations
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TL;DR: Four new triterpene saponins, clematomandshurica saponin A-D (1-4), together with three known sap onins (5-7) have been isolated from the roots and rhizomes of Clematis mand shurica and their structures were elucidated on the basis of their spectroscopic evidence and hydrolysis.
Abstract: Four new triterpene saponins, clematomandshurica saponins A−D (1−4), together with three known saponins (5−7) have been isolated from the roots and rhizomes of Clematis mandshurica. Their structures were elucidated on the basis of their spectroscopic evidence and hydrolysis. Clematomandshurica saponins A and B showed significant inhibitory activity on cyclooxygenase-2 (IC50 = 2.66 and 2.58 μM, respectively).
42 citations
Authors
Showing all 91 results
Name | H-index | Papers | Citations |
---|---|---|---|
Peng-Fei Tu | 45 | 487 | 8607 |
Shepo Shi | 21 | 72 | 1117 |
Wen-bin He | 7 | 11 | 237 |
Dan Jiang | 6 | 7 | 137 |
Cai-Xia Dong | 4 | 5 | 94 |
Huan Wang | 2 | 2 | 15 |
Rui-hui Wang | 2 | 2 | 30 |
Jun-Long Zhang | 2 | 2 | 29 |
Ping Yan | 2 | 3 | 11 |
Mei-Xia Zhu | 2 | 2 | 42 |
Huan-Xin Zhao | 2 | 2 | 17 |
Chen Fang | 2 | 2 | 11 |
Yong-hui Wang | 2 | 3 | 6 |
Hongxia Yuan | 2 | 3 | 14 |
Ran Zhou | 2 | 3 | 6 |