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Showing papers by "Transgene SA published in 1986"

Patent•
Expression and secretion vectors for hirudine by way of transformed yeasts

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Gerard Loison1, Paul Tolstoshev1, Yves Lemoine1, Jean-Pierre Lecocq1•
Transgene SA1
02 May 1986
TL;DR: In this paper, a functional block of DNA enabling to prepare hirudine from yeast, characterized in that it comprises at least: - the gene of H or one of its variants (gene H); a DNA sequence (Str) comprising the signals providing for the transcription of the gene H by the yeast.
Abstract: Functional block of DNA enabling to prepare hirudine from yeast, characterized in that it comprises at least: - the gene of hirudine or one of its variants (gene H); - A DNA sequence (Str) comprising the signals providing for the transcription of the gene H by the yeast.

28 citations

Patent•
Expression vector for gamma interferon in cells of mammals, process for its use, product obtained and pharmaceutical composition containing gamma interferon

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Thérèse Faure1, Paul Sondermeyer1, Werner Altenburger1, Jean-Pierre Lecocq1•
Transgene SA1
16 Jun 1986
TL;DR: In this paper, the cow-pox virus was used to infect mammalian cells in order to obtain cells producing IFN- gamma which may be used in therapeutical compositions, and the authors described a virus that comprises all or part of a DNA sequence coding for IFN gamma.
Abstract: The invention relates to a virus of the cow-pox, characterized in that it comprises all or part of a DNA sequence coding for IFN- gamma . This virus may be used to infect mammal cells in order to obtain cells producing IFN- gamma which may be used in therapeutical compositions.

22 citations

Journal Article•DOI•
RNA structural elements for expression in Escherichia coli: α1-antitrypsin synthesis using translation control elements based on the cII ribosome-binding site of phage λ

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Luc-Henri Tessier1, Sophie Jallat1, Martine Sauvageot1, Ronald G. Crystal2, Michael Courtney1 •
Transgene SA1, National Institutes of Health2
24 Nov 1986-FEBS Letters
TL;DR: Analysis of a series of λ cII::α1‐antitrypsin (α1AT) gene fusions showed that increased α1AT expression correlated with the stabilisation of a particular computer‐predicted RNA secondary structure, indicating that RNA primary and secondary structure determinants can operate in concert to dictate the efficiency of protein synthesis.

16 citations

Patent•
Expression of human IL-2 in mammalian cells by a recombined pox virus

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Marie-Paul Kieny1, Paul Sondermeyer1, Jean-Pierre Lecocq1•
Transgene SA1
19 Jun 1986
TL;DR: The present invention relates to a poxvirus characterized in that it comprises all or part of DNA sequence coding for a human IL-2 protein this paper, which is the same as the one described in this paper.
Abstract: The present invention relates to a poxvirus characterized in that it comprises all or part of DNA sequence coding for a human IL-2 protein.

6 citations