Jean-Pierre Lecocq

TL;DR: The respiratory epithelium is a potential site for somatic gene therapy for the common hereditary disorders alpha 1-antitrypsin (alpha 1AT) deficiency and cystic fibrosis by infecting epithelial cells of the cotton rat respiratory tract in vitro and in vivo.

TL;DR: The ΔF508 mutation seems to have two major consequences, an abnormal translocation of the CFTR protein which limits membrane insertion, and an abnormal function in mediating Cl- transport.

TL;DR: It is shown that expression of F in a CD4+ cell line down-regulates the CD4 (T4) antigen and suggests that F is important in the pathophysiology of AIDS (aquired immune deficiency syndrome).

TL;DR: To clone a thrombin receptor cDNA, selective amplification of mRNA sequences displaying homology to the transmembrane domains of G‐protein‐coupled receptor genes was performed by polymerase chain reaction.

TL;DR: Strong complementarity between the ribosome binding site and 16S rRNA suggests that xylE mRNA translation in B. subtilis may commence at the same site as that recognized by P. putida, and sensitive color assay offers an approach to develop plasmid gene expression vectors for a wide variety of host organisms.