Showing papers by "Universidade Federal de Minas Gerais published in 1968"
TL;DR: In mice experimentally infected with Schistosoma mansoni, praziquantel (2-cyclohexylcarbonyl-1,3,4,6,7,11b-hexahydro-2H-pyrazino[2,1-a]isoquinoline-4-one), administered orally at the levels of 100 and 50 mg/kg, for 5 consecutive days, produced oogram changes in all animals and a pronounced hepatic shift
Abstract: In mice experimentally infected with Schistosoma mansoni, praziquantel (2-cyclohexylcarbonyl-1,3,4,6,7,11b-hexahydro-2H-pyrazino[2,1-a]isoquinoline-4-one), administered orally at the levels of 100 and 50 mg/kg, for 5 consecutive days, produced oogram changes in all animals and a pronounced hepatic shift of schistosomes (97.1 and 89.1, respectively). At lowest levels (12.5 and 6.3 mg/kg), alterations in the oogram could still be detected, although hepatic shift of schistosomes was no more evident. After a single intramuscular injection, the results obtained paralleled those observed with a single-dose oral treatment. The hepatic shift was only moderate at 200 and 100 mg/kg and the percentages of worms retained in the liver, after perfusion, were particularly low. When nasal route in a 1-day regimen was used, the results obtained were slightly less evident as compared with those observed by oral route (5-day schedule).
150 citations
TL;DR: In this paper, the Gibbs test was used to determine the hydroxylation pattern of xanthones in the presence of certain additives, such as aluminum chloride and 2,6-dichlorobenzoquinone chloroimide.
65 citations
TL;DR: A sublethal dose of the venom of the scorpion Tityus serrulatus produced a depletion of adrenal gland catecholamines, and the effect was blocked on denervation of the adrenals.
44 citations
TL;DR: An investigation was carried out with model compounds designed to allow the study of the effects of small substituents (methyl groups), uncharged isosteres, methyl substitution on the benzamidinium nucleus, and extension of the aromatic side chain, on the binding properties of the hydrophobic binding site of the trypsin active center.
38 citations
TL;DR: Isopentenylated xanthones from Brazilian Kielmeyera and Calophyllum species include the hitherto undescribed 6-dehydroxy-jacareubin (Ic), guanandin (IIa), isoguan andin (III) and dehydrocycloguanand in (XII).
32 citations
TL;DR: Labeled Biomphalaria glabrata, displaying a remarkable radioactivity, were obtained by exposing the snails to H275SeO3 or 75Se-methionine and separate counts of the shell and soft tissues showed that radioselenium was incorporated chiefly by the latter.
28 citations
TL;DR: In this paper, an electron-nuclear double-resonance (ENDOR) study of the self-trapped hole in LiF is reported, where the hole is shared by two halide-ion lattice sites in the form of a negatively charged diatomic halide molecule.
Abstract: An electron-nuclear double-resonance (ENDOR) study of the self-trapped hole in LiF is reported. The results agree with the accepted model, i.e., the hole is shared by two halide-ion lattice sites in the form of a negatively charged diatomic halide molecule ($\mathrm{F}_{2}^{}{}_{}{}^{\ensuremath{-}}$ in this study). The variations in the ENDOR spectra for different ESR lines is investigated theoretically and experimentally. The observation of negative-contact hyperfine constants for most ENDOR nuclei is explained by exchange polarization of the "closed-shell" molecular orbitals.
19 citations
30 Nov 1968
1 citations