Showing papers by "University of Düsseldorf published in 1974"
TL;DR: The diastolic phase of pressure pulses recorded over a segment of the thoracic aorta several centimeters long centered about 4 cm cephalad to the dorsal insertion of the diaphragm could be closely approximated by a straight line on a semilogarithmic scale and correlated well with concomitant variations in peripheral vascular resistance.
Abstract: Large changes in stroke volume and peripheral vascular resistance were induced by varying the heart rate and by intra-aortically infusing acetylcholine or angiotensin II in six dogs with heart block and electromagnetic flowmeters chronically implanted around their ascending aortas. Changes in stroke volume, aortic and atrial pressures, and systemic resistance were monitored continuously for 3-6 hours under morphine-pentobarbital anesthesia. The characteristics of diastolic pressure decay at heart rates ranging from 60 beats/min to 200 beats/min and during transient periods of asystole were studied, especially with reference to the distortions caused by reflected pressure waves. The diastolic phase of pressure pulses recorded over a segment of the thoracic aorta several centimeters long centered about 4 cm cephalad to the dorsal insertion of the diaphragm could be closely approximated by a straight line on a semilogarithmic scale. Under the conditions of these experiments, changes in the slope of that line and of its reciprocal, the time constant, correlated well with concomitant variations in peripheral vascular resistance. This relationship appears to be of practical value for continuous monitoring of systemic resistance directly from the diastolic segments of pressure pulses recorded from the lower thoracic aorta.
101 citations
TL;DR: In this strain of mice the postprandial blood glucose and plasma insulin exhibited the strain-specific pattern, independent of the diet, and in older animals fed either diet the glucose tolerance decreased.
81 citations
TL;DR: The heart muscle cells of eight pigs 18 days, 30 days, 6 months, and 8 months old were isolated by potash lye and hints at the mitotic origin of the nuclear rows are micronuclei and nuclear bridges.
Abstract: The heart muscle cells of eight pigs 18 days, 30 days, 6 months, and 8 months old were isolated by potash lye Most cells contain 2, 4, 8, or 16 nuclei of equal or unequal size The part of cells with 4, 8, or 16 nuclei increases between the age of 18 days and 6 months Most nuclei are diploid but larger ones are polyploid with a DNA content up to 32C There are topographical differences between the parts of the heart with the highest proportion of multinuclear cells at the base of the left ventricle and the lowest in the right heart Hints at the mitotic origin of the nuclear rows are micronuclei and nuclear bridges The isolation procedure permits cytophotometric DNA measurements after Feulgen stain Furthermore the percentage of nuclear rows not corresponding to a total DNA of 4, 8, 16, or 32 diploid nuclei makes it possible to estimate the frequency of fragmentations during the isolation procedure It comes up to approximately 5% of the cells
69 citations
TL;DR: A classification between true tumours of the condyle and condylar hyperplasia made and one rare and very interesting case, which is not a tumour, has been included to illustrate the complexity and sometimes uncertainty in diagnosis.
39 citations
TL;DR: The hypothesis that the antennae of insects as air current sense organs have anything to do with the control of movements which are dependent on the surrounding air for their stimulation has been tested and is reported below.
Abstract: THE function of the antennae of insects as air current sense organs and their relationship to flight control has already been investigated by behavioural studies in flies, bees and locusts1–6, all of which are excellent fliers. The dragonfly is also an excellent flier although it possesses a very different flight apparatus7–9. Even though flight is apparently influenced by the eyes and the neck sense organs of the dragonfly10,11, it seems unlikely that these organs have anything to do with the control of movements which are dependent on the surrounding air for their stimulation. For the measurement of flying speed relative to the surrounding air, for example, one might expect that, just as in the other insects, the antennae play an important and specific role. It is this hypothesis which has been tested in the present work, the results of which are reported below.
32 citations
01 Nov 1974
TL;DR: In this article, the saddle-point field of a wave packet (a pulsed beam) in a homogeneous medium with moderate absorption is calculated using the saddle point method. And the packet velocity v is approximately equal to the real part of ∂ω S /∂k S where k S, ω S are the saddlepoint values of the propagation vector and the angular frequency.
Abstract: Hamilton's equations for geometric optics contain the quantity ∂ω/∂k which is complex in absorbing media. To investigate its physical meaning, the field of a wave packet (a pulsed beam) in a homogeneous medium with moderate absorption is calculated using the saddle-point method. The packet velocity v is approximately equal to the real part of ∂ω S /∂k S where k S , ω S are the saddle-point values of the propagation vector and the angular frequency. The imaginary part of ∂ω S /∂k S can physically be interpreted in terms of v and derivatives of Re k S ċ σ, Re ω S τ in the direction of v, where σ1/2and τ1/2are beam-width and pulse duration, respectively.
28 citations
TL;DR: The smooth muscle in the chicken gizzard contains myoglobin this article and the myoglobin content is many times higher in concentration in the gizzard than in other muscles of the same animal.
23 citations
TL;DR: In recovery experiments with 4 methods for the evaluation of T4, good agreement between expected and measured values, even in the high concentration range, was seen with the radioimmunoassay as well as with the FBI determination, whereas poor agreement was found with two displacement techniques.
15 citations
TL;DR: Clinical and histological cases are presented to illustrate the problems of differential diagnosis and the mechanism of fracture in relation to fractures of the clavicle.
15 citations
TL;DR: According to the order of priorities dictated by frequency, 195 tumours of the head and neck in children were systematized and analysed clinically and showed conspiracuous differences in comparison with adult tumours.
14 citations
TL;DR: A chestnut-sized malignant synovioma of the left knee of a 25-year-old-male has been investigated by light and electron microscopy and revealed an imitation of the microvillous surface structure of normal synoviocytes by the tumor cells which produced numerous “inner surfaces” resulting in pseudotubular clefts and spaces.
Abstract: Summary A chestnut-sized malignant synovioma of the left knee of a 25-year-old-male has been investigated by light and electron microscopy. Histologically, characteristic solid sarcomatous and pseudotubular structures are evident. Electron microscopy revealed an imitation of the microvillous surface structure of normal synoviocytes by the tumor cells which produced numerous “inner surfaces” resulting in pseudotubular clefts and spaces. The differential diagnosis of synoviomas and mesotheliomas is possible by the cytological and histological features of these tumors.
TL;DR: A surgical technique for correction of asymmetric mandibular prognathism, and suggestions for checking relapse, have been included.
TL;DR: In this paper, a generalized version of the G index of agreement is presented, allowing for its application in multiple ratings, and an illustrative example is provided, using hypothetical data.
Abstract: A generalization of the G index of agreement is presented, allowing for its application in multiple ratings. The generalized coefficient is intended for use in the psychiatric clinic. An illustrative example is provided, using hypothetical data.
TL;DR: The data suggest that immune insulitis does not run a chronic progressive course but represent a temporary immunity phenomenon, and the occurrence of diabetes mellitus at an early phase of immunization may possibly be due to transient autoaggressive mechanisms to B cells at the climax of immuneinsulitis.
Abstract: Rabbits were immunized in different ways with bovine insulin in order to study the influence of duration and mode of immunization on the course of experimental immune insulitis and on the induction of diabetes mellitus. 2 groups (II, III) of 10 animals each received four insulin immunizations within four weeks either with predominantly Freund's adjuvant incomplete (FAI) or with exlusively Freund's adjuvant complete (FAC). 3 groups of 10 to 12 animals each were immunized with insulin for a period of 16 weeks. Within this time group IV received four immunizations with predominantly FAI, group V received seven immunization with predominantly FAC, and group VI sixteen immunizations with predominantly FAI.
TL;DR: In this paper, the kombinierte Durchfuhrung des Insulinhypoglykamie/LH-RH-Tests with Bestimmung des STH, LH, FSH and Cortisol im Plasma von mannlichen Normalpersonen berichtet.
Abstract: Es wird uber die kombinierte Durchfuhrung des Insulinhypoglykamie/LH-RH-Tests mit Bestimmung des STH, LH, FSH und Cortisol im Plasma von mannlichen Normalpersonen berichtet. Die simultane Anwendung beider Stimulationstests bietet die Moglichkeit, gleichzeitig die somatotrope, gonadotrope und indirekt die adrenocorticotrope Partialfunktion des HVL zu beurteilen.
TL;DR: The frequency of spinal and costal anomalies in infants with congenital esophageal atresia is demonstrated in 20 cases and these anomalies are easily recognized in radiographs they can provide additional hints in suspected esophagesatresia.
Abstract: The frequency of spinal and costal anomalies in infants with congenital esophageal atresia is demonstrated in 20 cases. Abnormal numbers of vertebral bodies in the thoracic and lumbar spine were found in 50% of the patients. The maximum number of thoraco-lumbar vertebrae was 19. Malformations of the vertebral bodies were frequent (35%). 13 pairs of ribs were found in 25% of the cases. Because these anomalies are easily recognized in radiographs they can provide additional hints in suspected esophageal atresia.
TL;DR: The relevancy of determining the impressive character of handwriting was proved by the work of three different independent investigators, each separately assessing the samples resulting from the same 300 handwriting tests, and the problem of different individual predispositions to the neuroleptic threshold is discussed.
Abstract: This paper discusses the present state of investigations concerning the concepts of ‘neuroleptic threshold’ and fine motor extrapyramidal inhibition. The publication also includes reports on studies carried out by thirty-one collaborators from the Haase work-team based on over 50,000 handwriting tests. The main results of the following studies are presented and discussed:Investigations effected by fourteen authors on 328 cases of schizophrenia proving the close relationship between crossing the neuroleptic threshold and onset of the anti-psychotic effect. By a gradual increase of dosage a neuroleptic-anti-psychotic action was obtained in the days following the crossing of the neuroleptic threshold for a total of 87% of cases, 52% of which took place in the first three days, another 16% within the following three days and the rest after a longer interval.In another series of investigations the actions of a neuroleptic drug above and under the neuroleptic threshold were systematically compared in twenty-fou...
TL;DR: The basic requirement for the experiment was the development of mieromethod for analysis of the gentamycin concentrations according to Rosin, allowing to pinpoint the gentamyein concentration in amounts of 1 ~1 of perilymph.
Abstract: The dependence of the gentamyein concentration in the peri lymph on the concentration curve in the blood was the object of the following examination. The basic requirement for our experiment was the development of mieromethod for analysis of the gentamycin concentrations according to Rosin, allowing to pinpoint the gentamyein concentration in amounts of 1 ~1 of perilymph. The lowest margin is 0.625 meg/ml.
TL;DR: It is necessary to apply bactericidal and nontoxic antibiotics maintaining a high bone concentration and include the actual tested bacterial spectrum of the clinic to keep the incidence of infections in orthopedic surgery low.
Abstract: Selbst wenn keine sogenannte Sterilbox zur Verfugung steht, ist es moglich, die Infektionsrate bei orthopadischen Operationen niedrig zu halten. Masgebend ist die Beachtung allgemeiner Grundsatze der Asepsis, Antisepsis und der antibakteriellen Chemotherapie. Bactericide, atoxische knochengangige Breitbandantibiotica werden entsprechend der jeweiligen Erreger- und Resistenzsituation an einer Klinik nur bei besonders infektionsgefahrdeten Operationen eingesetzt. In den Jahren 1971 bis 1973 wurden in der Orthopadischen Universitatsklinik Dusseldorf 1459 aseptische orthopadische Operationen durchgefuhrt. Im gleichen Zeitraum traten 12 (0,8%) postoperative Wundheilungsstorungen auf.
TL;DR: The lipolytic activity of the individual fat cells is similar in young, normal-weight men, in young metabolically intact mice and in those mice that later on will develop diabetes and obesity, depending on their genetic code.
01 Nov 1974
TL;DR: It is assumed that the spleen dialysate is able to increase the gonadotropin effect on the ovaries through increased follicular atresia and disquamating granulosa.
Abstract: The stimulating effect of a spleen dialysate on the testicles and the accessory genital organs motivated the authors to test this dialysate on the ovaries. Also on the ovaries a different influence was observed.In comparison to the control animals, the enzyme pattern: lactate dehydrogenase, steroid-3-β-ol-dehydrogenase, alkaline phosphatase, succinate dehydrogenase, and, glucose-6-phosphate-dehydrogenase is significantly changed. The effect is manifested by an increase of the tertiary follicles, increased follicular atresia and disquamating granulosa. On the basis of these findings we assume that the spleen dialysate is able to increase the gonadotropin effect on the ovaries.