University of Saint Joseph

About: University of Saint Joseph is a education organization based out in West Hartford, Connecticut, United States. It is known for research contribution in the topics: Population & Health care. The organization has 473 authors who have published 660 publications receiving 6427 citations.

The nature of social dominance orientation: Theorizing and measuring preferences for intergroup inequality using the new SDO₇ scale.

Abstract: A new conceptualization and measurement of social dominance orientation-individual differences in the preference for group based hierarchy and inequality-is introduced. In contrast to previous measures of social dominance orientation that were designed to be unidimensional, the new measure (SDO7) embeds theoretically grounded subdimensions of SDO-SDO-Dominance (SDO-D) and SDO-Egalitarianism (SDO-E). SDO-D constitutes a preference for systems of group-based dominance in which high status groups forcefully oppress lower status groups. SDO-E constitutes a preference for systems of group-based inequality that are maintained by an interrelated network of subtle hierarchy-enhancing ideologies and social policies. Confirmatory factor and criterion validity analyses confirmed that SDO-D and SDO-E are theoretically distinct and dissociate in terms of the intergroup outcomes they best predict. For the first time, distinct personality and individual difference bases of SDO-D and SDO-E are outlined. We clarify the construct validity of SDO by strictly assessing a preference for dominance hierarchies in general, removing a possible confound relating to support for hierarchy benefitting the ingroup. Consistent with this, results show that among members of a disadvantaged ethnic minority group (African Americans), endorsement of SDO7 is inversely related to ingroup identity. We further demonstrate these effects using nationally representative samples of U.S. Blacks and Whites, documenting the generalizability of these findings. Finally, we introduce and validate a brief 4-item measure of each dimension. This article importantly extends our theoretical understanding of one of the most generative constructs in social psychology, and introduces powerful new tools for its measurement.

Understanding the Differences between HusserlâÂÂs (Descriptive) and HeideggerâÂÂs (Interpretive) Phenomenological Research

Abstract: Phenomenology is one of several qualitative research traditions. Undergraduate and graduate nursing students have sought to understand the differences between Husserl’s descriptive and Heidegger’s interpretive phenomenology. This article is a basic resource for nursing students that describes and interprets the differences between the two philosophical phenomenological schools of thought. The origin of phenomenology is presented. A descriptive and an interpretive article from two peer reviewed nursing journals are compared and contrasted based on their purpose, data collection and data analysis. The selected articles were chosen based on their topic of relevance related to nursing students in educational settings.

Characterization of PD-L1 Expression and Associated T-cell Infiltrates in Metastatic Melanoma Samples from Variable Anatomic Sites

Abstract: Purpose: Programmed death ligand-1 (PD-L1) tumor expression represents a mechanism of immune escape for melanoma cells. Drugs blocking PD-L1 or its receptor have shown unprecedented activity in melanoma, and our purpose was to characterize tumor PD-L1 expression and associated T-cell infiltration in metastatic melanomas. Experimental Design: We used a tissue microarray (TMA) consisting of two cores from 95 metastatic melanomas characterized for clinical stage, outcome, and anatomic site of disease. We assessed PD-L1 expression and tumor-infiltrating lymphocyte (TIL) content (total T cells and CD4/CD8 subsets) by quantitative immunofluorescence. Results: High PD-L1 expression was associated with improved survival ( P = 0.02) and higher T-cell content ( P = 0.0005). Higher T-cell content (total and CD8 cells) was independently associated with improved overall survival; PD-L1 expression was not independently prognostic. High TIL content in extracerebral metastases was associated with increased time to developing brain metastases ( P = 0.03). Cerebral and dermal metastases had slightly lower PD-L1 expression than other sites, not statistically significant. Cerebral metastases had less T cells ( P = 0.01). Conclusions: T-cell–infiltrated melanomas, particularly those with high CD8 T-cell content, are more likely to be associated with PD-L1 expression in tumor cells, an improved prognosis, and increased time to development of brain metastases. Studies of T-cell content and subsets should be incorporated into trials of PD-1/PD-L1 inhibitors to determine their predictive value. Furthermore, additional studies of anatomic sites with less PD-L1 expression and T-cell infiltrate are needed to determine if discordant responses to PD-1/PD-L1 inhibitors are seen at those sites. Clin Cancer Res; 21(13); 3052–60. ©2015 AACR .