Institution
Vikram University
Education•Ujjain, Madhya Pradesh, India•
About: Vikram University is a education organization based out in Ujjain, Madhya Pradesh, India. It is known for research contribution in the topics: Estimator & Mean squared error. The organization has 888 authors who have published 1257 publications receiving 13780 citations. The organization is also known as: Vikram Viśvavidyālaya.
Topics: Estimator, Mean squared error, Efficient estimator, Minimum-variance unbiased estimator, Bias of an estimator
Papers published on a yearly basis
Papers
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TL;DR: Sawdust, a relatively abundant and inexpensive material is currently being investigated as an adsorbent to remove contaminants from water as discussed by the authors, and chemical substances including dyes, oil, toxic salts and heavy metals can be removed very effectively with the organic material.
849 citations
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TL;DR: In this article, an estimator using a transformed auxiliary variable has been defined for estimating the finite population mean Y of the study character y. The bias and mean-squared error of the proposed estimator have been obtained.
Abstract: For estimating the finite population mean Y of the study character y, an estimator using a transformed auxiliary variable has been defined. The bias and mean-squared error (MSE) of the proposed estimator have been obtained. The regions of preference have been obtained under which it is better than usual unbiased estimator y, the ratio estimator y R = yX/x, SISODIA and DWIVEDI (1981) estimator y s = y(X + C x )/(x + C x ) and SINGH and KAKRAN (1993) estimator y k = y[X + β 2 (x)]/x + β 2 (x)]. An empirical study has been carried out to demonstrate the superiority of the suggested estimator over the others.
304 citations
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TL;DR: The contribution of the caspases and their regulators in monocyte/macrophage cell fate is summarized and discusses how these molecules orchestrate the initiation, maintenance, and resolution of inflammation.
Abstract: Monocytes and macrophages are central cells of the innate immune system, responsible for defending against diverse pathogens. While they originate from a common myeloid precursor and share functions in innate immunity, each has a very distinct life span finely tuned by the apoptotic caspases. Normally, circulating monocytes are short-lived and undergo spontaneous apoptosis on a daily basis. Macrophages, however, have a longer life span. In chronic inflammatory diseases and, as recently recognized, in the tumor microenvironment, the inhibition of the apoptotic program promotes monocyte survival contributing to the accumulation of macrophages and the persistence of an inflammatory milieu. A complex network of differentiation factors and inflammatory stimuli determine monocyte/macrophage life span by blocking the apoptotic pathway and activating a myriad of survival pathways. Our understanding of apoptosis has flourished over the last decade, and its relevance in the regulation of the immune system is now indisputable. Nevertheless, how the complicated networks of survival and apoptotic regulators are integrated to determine cellular life span remains elusive. This review summarizes the contribution of the caspases and their regulators in monocyte/macrophage cell fate and discusses how these molecules orchestrate the initiation, maintenance, and resolution of inflammation. More provocatively, we discuss possible strategies to control inflammation by manipulating leukocyte life span.
267 citations
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TL;DR: A high rate of oxidative damage to mammalian DNA has been demonstrated by measuring oxidized DNA bases excreted in urine after DNA repair, directly related to the metabolic rate and inversely related to life span of the organism.
Abstract: Reactive oxygen species (ROS) such as the superoxide anion radical (O2.-) hydrogen peroxide (H2O2) and hydroxyl radical (.OH) have been implicated in the pathophysiology of various states, including ischemia reperfusion injury, haemorrhagic shock, atherosclerosis, heart failure, acute hypertension and cancer. The free radicals, nitric oxide (NO) and O2.- react to form peroxynitrite (ONOO-), a potent cytotoxic oxidant. A potential mechanism of oxidative damage is the nitration of tyrosine residues of protein, peroxidation of lipids, degradation of DNA and oligonucleosomal fragments. Several mechanisms are responsible for the protection of the cells from potential cytotoxic damage caused by free radicals. Cells have developed various enzymatic and nonenzymatic defense systems to control excited oxygen species, however, a certain fraction escapes the cellular defense and may cause permanent or transient damage to nucleic acids within the cells, leading to such events as DNA strand breakage and disruption of Ca2+ metabolism. There is currently great interest in the possible role of ROS in causing DNA damage that leads to cancer and spontaneous mutations. A high rate of oxidative damage to mammalian DNA has been demonstrated by measuring oxidized DNA bases excreted in urine after DNA repair. The rate of oxidative DNA damage is directly related to the metabolic rate and inversely related to life span of the organism.
256 citations
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TL;DR: Stigmasterol, isolated from the bark of Butea monosperma was evaluated for its thyroid hormone and glucose regulatory efficacy in mice and a decrease in the hepatic lipid peroxidation (LPO) and an increase in the activities of catalase, superoxide dismutase and glutathione suggested its antioxidative potential.
228 citations
Authors
Showing all 894 results
Name | H-index | Papers | Citations |
---|---|---|---|
Rajesh Singh | 46 | 692 | 10339 |
Pardeep Singh | 44 | 103 | 5382 |
Umesh Singh | 35 | 385 | 4945 |
Maya Shankar Singh | 31 | 245 | 4261 |
Mordhwaj S. Parihar | 26 | 45 | 3095 |
Housila P. Singh | 23 | 46 | 1633 |
Arup Neogi | 23 | 189 | 2112 |
Suresh C. Ameta | 22 | 142 | 1480 |
Ram N. Mohapatra | 20 | 115 | 1595 |
Housila P. Singh | 19 | 225 | 1651 |
S. N. Deepa | 19 | 83 | 3089 |
Himanshu Arora | 18 | 59 | 1080 |
Arti Parihar | 18 | 31 | 1720 |
Pratima Sen | 17 | 130 | 1018 |
Paras M. Agrawal | 15 | 22 | 798 |