Showing papers in "Advances in Chronic Kidney Disease in 2022"

TL;DR: The epidemiology, pathogenesis, and diagnosis of paraneoplastic glomerular processes are focused on and target antigens in membranous nephropathy such as thrombospondin type-1 domain-containing protein 7A and neural epidermal growth factor-like 1 protein are identified that appear to be promising in differentiating a primary vs paranoplastic cause of membranious nephrodisiacs.

TL;DR: Results from small- to medium-sized interventional trials suggest that base therapy can limit chronic kidney disease progression or associated adverse events, and that interrupting this cycle through base administration can prevent further kidney injury.

TL;DR: In this paper , the authors summarized the emergence and impact of value-based programs on the quality and costs of kidney care, with a focus on federal programs, and highlighted the key opportunities in valuebased kidney care including shifting the focus toward chronic kidney disease, enhancing population health management capabilities, improving quality measurement and leveraging programs to advance health equity.

TL;DR: The diagnosis and potential interventions for congenital anomalies of the kidney and urinary tract, including strategies to address bladder dysfunction that is often seen in children with CAKUT, are outlined.

TL;DR: In this paper , the acid-base status is derived from the interaction of net H+ balance with body buffers and relies on the H2CO3/HCO3- buffer pair for its assessment.

TL;DR: An overview of the current state of federal research funding for kidney disease within the United States is provided and ongoing advocacy efforts and programs that aim to increase federal funds for kidney-related research and accelerate the development of new and better therapies are discussed.

TL;DR: Two new payment models under the supervision of the Centers for Medicare & Medicaid Services Innovation Center represent another step toward value-based care and, if successful, should yield great benefits for patients with kidney disease.

TL;DR: The individual and family support systems as they relate to adolescents and young adults with chronic or end-stage kidney disease and patients with cognitive and developmental disability are discussed.

TL;DR: It has become apparent that TMA syndromes are an emerging field in nephrology, rheumatology, and hematology, where much work remains in genetics, molecular biology, and therapeutics to unravel the puzzle of the relationships and distinctions apparent between the different subclasses of TMA Syndromes.

TL;DR: Given the higher morbidity and mortality related to development kidney disease, nephrologists need to be aware of the various causes and best treatment options.

TL;DR: Adequate hydration, angiotensin-converting enzyme inhibitors, and adequate control of sickle cell are the main stay of treatment for albuminuria.

TL;DR: The approach to hyponatremia should focus on cancer-related etiologies, such as syndrome of inappropriate antidiuretic hormone, to the exclusion of other causes, and pseudohyperkalemia is particularly common in patients with hematological cancers.

TL;DR: Basic concepts in machine learning are introduced and recent research in each of these domains are reviewed to advance clinical and biochemical understanding of acute kidney injury.

TL;DR: The strategy of pretransplant wait time management may need to be revisited as cancer therapies improve, which is most applicable to patients with a history of multiple myeloma.

TL;DR: The adverse effects of acid on bone is underappreoicated, under-investigated, and the potential benefits of alkali therapy is not generrally known.

TL;DR: The various mechanisms responsible for the development of metabolic acidosis are briefly reviewed, and the metabolic acidoses are categorized both by mechanism and by the presence or absence of an increased anion gap.

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TL;DR: The effects of various biomarkers and comorbidities seen in the intersection of obesity and CKD in the adolescent population are analyzed to provide care providers with the full spectrum of treatment options for obesity in adolescent populations.

TL;DR: Clinicians are challenged to consider the growing evidence for a spectrum of acid-accumulation disorders that include lesser degrees of acid accumulation than metabolic acidosis yet are harmful.

TL;DR: The National Kidney Foundation (NKF) and American Society of Nephrology (AS Nephrology) as mentioned in this paper established a task force on reassessing the use of race in diagnosing kidney disease and recommended the immediate implementation of the 2020 chronic kidney disease-epidemiology creatinine equation refit without race in all US laboratories.

TL;DR: The aim of the present review is to explore the various intervention strategies that increase or normalize serum [HCO3-] in patients with CKD-associated MA or low normal serum[HCO2-] that may further slow progression of CKD.

TL;DR: The clinical signs and symptoms of tubular disorders, as well as their diagnostic workup, including laboratory findings and imaging, during young adulthood, are highlighted.

TL;DR: The purpose of this review is to examine the specific mechanisms of each pathway through which metabolic acidosis affects muscle, the impact of metabolic acidotic disease on physical function, and the effect of treating metabolic Acidosis on functional outcomes.

TL;DR: Early nephrology evaluation may be helpful to assist with preservation of kidney function and prevention of further kidney injury.

TL;DR: The importance of training in hemodialysis catheter placement and kidney biopsy has come into question due to the small proportion of nephrologists performing these procedures today as mentioned in this paper .

TL;DR: This review will discuss the pitfalls of accurate measurement of kidney function and how kidney disease affects both pharmacodynamic and pharmacokinetic properties of drugs.

TL;DR: If supported by more extensive studies, blood gas analyses to confirm the acid-base disorder and newer ways for assessing the presence of acidosis such as urinary citrate measurements may become routine tools to evaluate and treat acid- base disorders in individuals with CKD.

TL;DR: Basic symptom management options are described as well as considerations for discussing goals of care, prognosis, and end of life in patients with cancer and kidney disease.

TL;DR: In this paper , the authors discuss the biochemistry of dietary precursors that affect acid or base production and show that eating a net acid-producing diet can produce an acid stress of severity proportional to the diet net acid load, as indexed by the steadystate renal net acid excretion rate.

TL;DR: The study of acid-base equilibrium and its relationship to diet and disease has been a subject of considerable speculation for at least several centuries as discussed by the authors , and little was known about the concepts of acids and bases, and no means were available to quantify the acid or alkaline load of foods or the pH of physiological processes.