Showing papers in "Biochemical and Biophysical Research Communications in 2023"

TL;DR: Aquaporin water channels facilitate water transport across cellular membranes and are essential in regulation of body water balance, and several AQPs are overexpressed or ectopically expressed in breast cancer as mentioned in this paper .

TL;DR: The role of ADHI in hepatic stellate cell (HSC) activation and the effect of 4-methylpyrazole (4-MP), an ADH inhibitor, on liver fibrosis induced by carbon tetrachloride (CCl4) in mice was explored in this paper .

TL;DR: In this paper , the 34-codon novel dwarf open reading frame (DWORF) micropeptide has been identified as a muscle-specific SERCA effector, capable of reversing the inhibitory effects of phospholamban and independently activating SERCA in the absence of PLB.

TL;DR: In this article , the authors investigated the potential roles of canagliflozin (Cana) on renal EMT and oxidative stress through its effects on sirtuin 3 (SIRT3) expression.

TL;DR: In this paper , Wu et al. showed that Enitrelvir is effective against newly emerging SARS-CoV-2 variants and globally prevalent 3C-like protease (3CLpro) mutations.

TL;DR: In this article , a mouse model of myocardial infarction was established by ligation of the left anterior descending coronary artery, and primary cultures of neonatal rat cardiomyocytes were submitted to hypoxic treatment to stimulate cellular injury in vitro.

TL;DR: In this paper , the authors investigated the relationship between DDX3X and nucleus pulposus (NP) pyroptosis and found that over-expression of DDX-3X induced NP cells and increased levels of NLRP3, IL-1β and IL-18.

TL;DR: In this paper , the authors used TM-containing liposomes with different phospholipids as surrogates of endothelial microparticle-TM and investigated their cofactor activities, finding that liposomal TM with phosphatidylethanolamine (PtEtn) showed increased protein C activation but decreased TAFI activation.

TL;DR: In this paper , the role of FoxO1 in the regulation of FGF21 expression was investigated, and it was shown that the repression acts on the FGF 21 gene promoter without affecting other PPARα target genes.

TL;DR: In this article , a non-invasive screening profile has been realized that can aid in determining T-cell activation state at single-cell level by relating intracellular Ca2+ intensity and motility of T-cells interacting with APC in a microfluidic chip.

TL;DR: In this article , the authors investigated the roles of TAZ and YAP in anoikis resistance in basal-like (BL) TNBC cells, which comprise a major subtype (>70%) of TNBC.

TL;DR: The authors showed that the sporogenic aerial hyphae of sflA and sflB mutants of Streptomyces coelicolor frequently branch, a phenomenon never seen in the wild-type strain.

TL;DR: In this paper , the role of FGF8 in the pathogenesis and its therapeutic potential of limb-girdle muscular dystrophy R18 (LGMD R18) was investigated.

TL;DR: In this article , conformation-specific protein binders were selected from a repebody scaffold composed of LRR (Leucine-rich repeat) modules through phage display and modular engineering against the active conformation of KRAS.

TL;DR: Wang et al. as mentioned in this paper used decellularized adipose tissue (DAT) and tremella polysaccharide (TPS), and loaded insulin (INS) into the DAT/TPS composite hydrogel to fabricate an efficient carrier for ADSCs in treating skin wound.

TL;DR: In this article , the authors reveal that the IMiD- or CELMoD-mediated binding of neo-substrates closely mimics the recognition of natural degrons.

TL;DR: In this article , the effects of oxytocin on ovarian steroidogenesis were investigated by utilizing primary culture of rat granulosa cells and human granulo-knucleus KGN cells.

TL;DR: In this paper , the Coulombic attraction between conserved acidic residues in the c-ring and the arginine in the a-subunit (aR) was observed to drive the rotation relative to the asubunit, and has been actually observed in previous molecular dynamics simulation with full atomistic description of Fo embedded in the membrane.

TL;DR: In this paper , the influence of the human MECP2 transgene on neural oscillation stability of the medial prefrontal cortex (mPFC), which is an important brain region for social interactions, was explored.

TL;DR: In this paper , the role of PP2Cα in regulating activities of both isoforms of GSK3α (one of the leading kinases for AD progression) and GSK-3β (a potential kinase for AD) was investigated.

TL;DR: In this article , free fatty acids (FFAs) and Fetuin-A were shown to upregulate DPP-IV expression in the pancreatic beta cells through the TLR4-NFkB pathway.

TL;DR: In this article , the role of circRNAs (circRNAs) in esophageal squamous cell carcinoma (ESCC) has been explored, and the relationship between circMAN1A2 expression and prognosis in patients with ESCC was analyzed.

TL;DR: In this article , the authors showed that KMT2D knockdown suppressed prostate cancer progression through the downregulation of paracrine IL-6 signaling, which is a pleiotropic cytokine that contributes to PCa progression.

TL;DR: In this paper , the effect of pharmacological intervention for ROCK1 is not clear, but it is shown that the inhibition of ROCK1 by Y-27632 and fasudil restores fatty acid oxidation in the glomeruli.

TL;DR: In this paper , the authors examined whether dysmetabolism of sphingolipids as major lipid components in the brain present in cerebrospinal fluid (CSF) of the patients.

TL;DR: In this paper , the authors reviewed the present disease-modifying therapies in clinical development for HD and examined the current landscape of developing clinical therapies and further investigated the pharmaceutical development of Huntington's medicine in the pharma industries.

TL;DR: In this paper , a 5/6 nephrectomy plus high phosphate diet chronic kidney disease (CKD) model was used to establish the vascular calcification by using fibroblast growth factor 21(FGF21) and showed that FGF21 was able to inhibit calcification both in vivo and in vitro.

TL;DR: In this paper , the authors employed the use of acute, high dose metformin to modulate complex I activity during early reperfusion to decrease cardiac injury in the high-risk aged heart.

TL;DR: Wang et al. as discussed by the authors found that succinylation of CTBP1 mediated by KAT2A suppresses the inhibitory activity on the transcription of CDH1, thus acting as an oncogene.

TL;DR: In this article , the authors developed an assay based on brain endothelial cells cultured on permeable recombinant silk nanomembranes for screening of transcytosis capability of biomolecules.