Biochemical Medicine and Metabolic Biology 

TL;DR: Structural-activity analysis revealed that the flavonoid molecule with polyhydroxylated substitutions on rings A and B, a 2,3-double bond, a free 3-hydroxyyl substitution and a 4-keto moiety, would confer upon the compound potent antiperoxidative properties.

TL;DR: Assays which measure complexes I to IV in human skeletal muscle mitochondria are evaluated and optimized to provide sensitive and reliable diagnostic techniques, particularly in situations where a partial interruption at a single complex needs to identified.

TL;DR: Cells from patients with Lebers hereditary optic neuropathy, Kearns-Sayre syndrome, myoclonus-epilepsy-lactic acidosis-stroke, and mild PDH complex deficiency survived well in galactose (5 mM)-containing medium, and could be used as a rapid screening test for skin fibroblasts with major oxidative defects.

TL;DR: The involvement of this system in metabolic microcompartmentation is discussed, as well as possible pathological consequences of its disruption in malignancy and genetic deficiencies of hexokinase, glycerol kinase, and porin.