Showing papers in "Contraception in 1988"

TL;DR: The reference period method, introduced to avoid the arbitrary rules and definitions required for an analysis based on the concept of a menstrual cycle, is discussed and its limitations presented.

TL;DR: It is concluded that the introduction of the 18-methyl in norethisterone (levonorgestel) increases both the binding to the progesterone and androgen receptors.

TL;DR: A comparative analysis of women's vaginal bleeding patterns using nine different methods of contraception, one natural and eight hormonal, confirms those of previous studies and shows that the methods of analysis recommended by WHO in 1985 still require substantial refinement.

TL;DR: Significant changes in the stiffness of the cervix were demonstrated in patients treated with Mifepristone, reflecting ripeness, and the treatment was simple and had no side effects.

TL;DR: Women using DMPA tolerated far greater menstrual disruption than subjects using any other method; they had no special difficulty in predicting either the time of onset or the length of their bleeding episodes.

TL;DR: Mid-luteal phase total urinary oestrogen excretion was found to be significantly reduced in women who had previously undergone tubal sterilization at least two years before assay, indicating that reduced ovarian function is associated with that procedure.

TL;DR: It is concluded that the relatively high serum concentrations of Gestodene are not only based on the binding to SHBG, but probably also on an impeded metabolism of gestodene.

TL;DR: Two once-a-month injectable contraceptive formulations were shown to be highly effective contraceptive preparations, which gave rise to few discontinuations due to menstrual cycle disturbances when compared with progestogen-only injectable contraceptives.

TL;DR: It is suggested that prolonged OC use may accelerate the onset of breast cancer for a small group of susceptible women while having no appreciable impact on overall risk.

TL;DR: Serum estradiol and progesterone were profoundly suppressed, except one woman who ovulated during the twelfth cycle probably due to a therapy with metamizol, trimethoprim and sulfamethoxazole.

TL;DR: There was a significant correlation between the SHBG levels and the area under the KDG-concentration-versus-time curves (AUC) indicating a pronounced influence of the serum steroid-binding protein upon the pharmacokinetics of KDG.

TL;DR: In this urban population selected for having the highest motivation and best breastfeeding performance, the association of breastfeeding with infertility was too weak to serve as an effective birth spacer, except for the period of lactational amenorrhea.

TL;DR: Two new methods of analysis of vaginal bleeding diaries are suggested, one of which measures trends over time in the occurrence of specific patterns and, a second, the relation between a woman's current experience and the probability of continuing method use.

TL;DR: Regional variations in bleeding patterns were particularly marked among women using DMPA, and increased over time: by their fourth injection interval, 25% of European women had amenorrhea, as compared with 72% of subjects in North Africa.

TL;DR: Three different regimens of RU 486, a progesterone receptor blocking agent, were compared for their ability to terminate early human pregnancy and women who subsequently aborted completely had significantly lower pretreatment levels of hCG than women with incomplete abortion or continuing pregnancy.

TL;DR: The efficacy of NORPLant-2 implants, however, was not acceptable during the fourth year of use in this study, and the latter system could become a suitable three-year contraceptive method, possibly with less bleeding disturbances than NORPLANT in the first year.

TL;DR: The experimental results support the thesis that gossypol inhibits sperm motility by blocking ATP production and utilization.

TL;DR: Magnetic resonance spectroscopy showed decline in tumor ATP levels occurring within 24 hours of treatment, suggesting that this non-invasive technique may serve as an early biochemical monitor of gossypol toxicity.

TL;DR: A randomized, comparative, multicenter clinical trial of TCu 380Ag and Multiload Cu 375 intrauterine devices was conducted and found the two IUDs were similar with respect to all event rates.

TL;DR: The use of the Lippes Loop was associated with the greatest increase in MBL which was sustained throughout the 24 months of observation and many women were in a marginal state of iron balance as evidenced by lower serum ferritin values.

TL;DR: Increasing the protein content of the medium to levels similar to low (8 mg/ml) and high (64 mg/ ml) values reported in human uterine fluid increased the dissolution rate of copper but also offered some protection against the toxic effects of copper metal and cuprous and cupric ions.

TL;DR: Multicentric clinical trials with a combination of only 75 mcg gestoden combined with 30 mcg EE confirm a reliable contraceptive efficacy combined with excellent cycle control and tolerance in 1,095 women over 14,281 treatment cycles.

TL;DR: The association of breastfeeding with amenorrhea was weak in comparison with what has been described for other populations and the risk of experiencing the first bleeding was reduced while fully breastfeeding with a high number of nursing episodes per day and night.

TL;DR: LCAT activity expressed as molar esterification rate (MER) rose in a more sustained way during EE + DG use than duringEE + LNG treatment, which shows a further significant difference between results of both treated groups for the Apo AI/Apo B ratio that was increased by Mono-EE + DG.

TL;DR: Findings though speculative indicate NORPLANT use to be non-contributory to cardiovascular risk and indeed it may be protective factor against such risks in this population of acceptors.

TL;DR: The results suggest that prior induced abortion does not significantly increase the risk of subsequent ectopic pregnancy and that women with a history of two or more prior induced abortions are not at risk.

TL;DR: It is concluded that D-35 is to be preferred over D-50 in treatment of acne and hirsutism and taking into account its reliable contraceptive effects, without unfavourable effects, as far as atherogenesis is concerned, on plasma lipids.

TL;DR: It is concluded that, after long-term administration of levonorgestrel via subdermal implants, the major part of the steroid is cleared from plasma within 96 h and that only trace amounts are detected in the following days.

TL;DR: Microdose contraception with these levonorgestrel-releasing implants appears to be a highly acceptable and effective modality suitable for Chinese women.

TL;DR: Menstrual diary records were obtained from women using either a natural method of contraception, a combined or progestogen-only oral contraceptive, a vaginal ring, or a long-acting injectable to examine the relationships between the subjects' bleeding patterns and their age, age at menarche, ponderal index, obstetric and contraceptive history and ethnic origin.