Showing papers in "Japanese Journal of Pharmacology in 1975"

TL;DR: It is concluded that diltiazem is an excitation-contraction uncoupler in the cardiac muscle cell and that the compound may exhibit its negative inotropic action by reducing in some way the intracellular concentration of free calcium ion available for the contractile mechanism.

TL;DR: Effects of acetylcholine and norepinephrine on atrial contractility and pacemaker activity were investigated in isolated and blood-perfused canine atrium preparations whith a support dog which were suspended in the blood-filled bath kept at 37 degrees C.

TL;DR: Both the lower and higher dose groups showed significant decrease in body weight due to withdrawal after 1 week of drug-food exposure, and Cross-physical dependence between phenobarbital and diazepam was demonstrated by this method.

TL;DR: Greatly evident were meningeal hemorrhage of the brain, bleeding in the lungs and vacuolic degeneration of the renal tubles, and extensive cellular damages in the bone marrow, intestine, spleen and lymph nodes.

TL;DR: A double column procedure was devised for simultaneous estimation of norepinephrine, normetanephrine, dopamine, 3-methoxytyramine, and 5-hydroxytryptamine in brain tissue with recovery rate in the neighborhood of 90% or higher with little column to column variation.

TL;DR: The experimental asthma caused by passive systemic anaphylaxis in guinea pigs was prevented with application of BPS, and BPS appears to be clinically applicable to extensive allergy related diseases.

TL;DR: Findings indicate that taurine antagonizes the stress-induced elevation of blood sugar by reducing adrenaline output from the adrenal gland, the regulatory mechanism most likly involves the inhibition of adrenaline release from adrenal medullary granules, possibly by stabilizing the membrane of the granules.

TL;DR: Diltiazem possesses the property of dilating coronary collaterals thus causing redistribution of intramyocardial blood flow, and in acute preparations, both diltsiazem and nitroglycerin showed no significant changes in PCP/MAP and RF/MAP.

TL;DR: Effects of antidepressant drugs on the amygdaloid after-discharge induced by stimulating the amygdala in rats implanted with chronic electrodes, were investigated in correlation with anti-muricidal effects as well as neurotoxicity.

TL;DR: The present experiments were performed in an attempt to examine how diltiazem affects the contractile force of the heart and coronary blood flow.

TL;DR: The present study provided an excellent animal model for studying the mechanism of duodenal ulcers and screening of antiulcer agents and data suggest that gastric juice may play an important role in the pathogenesis of cysteamine-induced ulcers.

TL;DR: 35S-Caerulein was administered intramuscularly into rats, rabbits, and mice and blood level of radioactivity in rats and rabbits reached the maximum at 5 and 15 min after administration, respectively, and then decreased rapidly.

TL;DR: In this article, the effects of polyamines on the central nervous system were studied in mice and it was shown that Spermidine (SPD) and Spermine (SPM) decreased spontaneous motor activity and lowered rectal temperature.

TL;DR: Results indicate that adrenergic beta-receptor exists in the coronary subserving a vasodilatation, however, the vasodillatation through this mechanism is of minor importance under physiological conditions and becomes completely masked in the presence of an overwhelmingly strong vasodolatation consequent to an increase in the myocardial O2 consumption.

TL;DR: Ascofuranone, a fungal metabolite, significantly reduced serum lipid levels, when orally administered to male Wistar rats fed a cholesterol rich diet, and resulted in a marked reduction of hepatic and cardiac cholesterol contents without affecting the body weight gain.

TL;DR: Papaverine and Aspaminol (1, 1-diphenyl-3-piperidinobutanol hydrochloride), hydralazine, caffeine Na benzoate and aminophylline were used at test drugs and there was little correlation between relaxing activities of the drugs used and their antiphosphodiesterase activities.

TL;DR: Urchi-toxins derived from Toxopneustes pileolus inhibited strongly and slightly the cardiac movement of experimental animals, respectively, while F4 and F5 rather stimulated the heart beat.

TL;DR: Relationship between the hypothermic effect and the increase of 5-HT synthesis in the brain after a large dose of salicylate and indomethacin is discussed.

TL;DR: The results suggest that the pressor effect of the beta- blocking agents may be due to their beta-blocking activities and the unmasking of alpha-receptor activities of the blood vessels and is attributed to a greater activity of the sympathetic nervous system in these rats as compared to normotensive rats.

TL;DR: Systematic research was performed on the acquisition of free-operant (Sidman-type) avoidance response, which is widely used for the study of psychotropic drugs, with the following results: There was a linear relation with negative inclination between the logarithm of mean numbers of shock delivered per sessions and the number of sessions.

TL;DR: On the whole, the action on energetic metabolism appears to be unrelated to the action believed to be exerted by drugs on cerebral vessels.