Showing papers in "Journal of Chemical Research-s in 1991"

Synthesis of unnatural amino acids

Abstract: Presented are efficient synthetic procedures for the following compoounds: the D- and L-isomers of N α -tert-butoxycarbonyl-β-(3-quinolyl) amine (N α -Boc-3-Quinal, 11 and 12), the D- and L-isomers of N α -tert-butoxycarbonyl-N e -nicotinoyl-lysine (N α -Boc-Niclys, 24 and 25), and the D- and L-isomers of N α -tert-butoxycarbonyl-N e -benzyloxycarbonyl-N e -isopropyllysine dicyclohexylamine salt (N α -Boc-N e -Z-Ilys DCHA salt, 26 and 27)

A new synthetic route to 4-bromo-7-methoxyphthalide and 3-hydroxy-7-methoxyphthalide from 2-methoxy-6-methylbenzoate : side-chain and nuclear bromination

Abstract: We describe bromination of 2-methoxy-6-methylbenzoates as an alternative route to phthalides

A new approach to imidazole derivatives

Abstract: Cycloadditions reactions of mesoionic 1,3-oxazolium-5-olates with N-(phenylmethylene) benzenesulphonamides give substituted imidazoles via elimination of carbon dioxide and benzenesulphinic acid; structural assignments were confirmed by 2D NOESY experiments

(+)-trans-1,4a-dimethyl-1,2,3,4,4a,5,6,7-octahydro-naphthalene, a trinoreudesmene from the Taiwanese Liverwort Bazzania fauriana

Abstract: A trinorsesquiterpene hydrocarbon has been isolated from the Taiwanese liverwort Bazzania fauriana and identified as (+)-trans-1,4a-dimethyl-1,2,3,4,4a,5,6,7-octahydronaphthalene

α,β-unsaturated nitriles in heterocyclic synthesis : a new synthetic route to condensed 2-alkoxy-4-aryl-3-cyano-pyridines

Abstract: A novel synthesis of condensed 2-alkoxy-4-aryl-3-cyanopyridines via reaction of cycloalkanones with arylmethylene-malononitriles or of 2-arylmethylenecycloalkanones with malononitrile in alcoholic sodium hydroxide or sodium alkoxide is reported

Structure-activity relations. VIII, Some novel designed 2,4-diaminopyrimidine inhibitors of dihydrofolic acid reductase

Abstract: A series of DHFR inhibitors, N-{2-, 3- and 4-[3-(2,4-diamino-6-methylpyrimidin-5-yloxy) propoxy] benzoyl}-L-glutamic acids, have been prepared, their design being based on receptor information; the 3-isomer is the strongest inhibitor of both E. coli and bovine liver DHFR, while both the 2- and 3-isomers show selectivity against the bacterial enzyme