Showing papers in "Journal of Dermatological Science Supplement in 2005"

TL;DR: The role of UV-induced signaling in the mechanism of premature skin aging (photoaging) is described, with emphasis on membrane-initiated, non-nuclear signaling events.

TL;DR: High amounts of PCBs and PCDFs are still present in a number of patients with Yusho, and the patients still suffered from various mucocutaneous and subjective symptoms, and these symptoms were correlated to the blood levels of polychlorinated congeners.

TL;DR: The lipid content and the concentration of each isomer of PCDDs, PCDFs and Co-PCBs in blood determined using the improved method were almost equal to those obtained by dioxin analysis organizations that used the conventional method to analyze the same blood samples.

TL;DR: Patients have recovered gradually from the typical Yusho symptoms of acneform eruptions, dermal pigmentation and increased eye discharge, however, enzyme- and/or hormone-mediated signs of high serum triglyceride, high serum thyroxine, immunoglobulin disorder, etc. remain persistent for more than 30 years.

TL;DR: This study investigated the relationship between clinical symptoms and dioxins, one of the causal agents, in patients with Kanemi Yusho oil poisoning disease by methods such as three-way analysis of variance (ANOVA).

TL;DR: Cytokine profile pattern varies from strain to strain, and that murine cutaneous LE models, like human LE patients, manifest a wide range of immunological abnormalities, including cytokines.

TL;DR: Results show that the irradiation of both UVA and UVB induces free radical oxidation of antioxidants and lipids, and indicate that oxidized diacylglycerols may play a role as an endogenous tumor promoter in UV-induced skin carcinogenesis.

TL;DR: Dioxin toxicity is summarized by focusing on the quenching systems of reactive oxygen species and chaperone proteins, and the possibility of the development of protective and therapeutic treatments for dioxinoxicity is discussed.

TL;DR: The analysis of the relationship between skin symptoms and blood concentrations of total PCDFs and total PCBs proves that not only PCBs but alsoPCDFs have an important role in the skin symptoms of Yusho.

TL;DR: UVA-induced downregulation of COL7A1 transcription in epidermal keratinocytes diminishes anchoring fibrils formation, resulting in skin fragility, and external factors including physical forces and UVB radiation in the sun-exposed areas may further promote deep wrinkle formation.

TL;DR: In this article, a study was conducted to ascertain whether parental exposure to dioxin-related compounds at a particular age affected the sex of subsequent offspring in Yusho, China.

TL;DR: Mammalian cells survive the flood of oxidative DNA damage by means of extensive repair of the damage, and mechanisms for tolerating DNA damage at replication have recently been discovered.

TL;DR: The sex ratio of children born to men exposed beforeage 20, men exposed after age 20, or to parents who were both exposed were not significantly different from the expected sex ratio.

TL;DR: The results suggest that the long half-life of PCBs and their accumulation in fatty tissue can lead to persistent mild impairment of the peripheral nervous system even long after exposure.

TL;DR: Three criteria for Yusho poisoning are proposed based on different approaches: 2,3,4,7,8-PeCDF level adjusted for age and sex, its one-tailed upper prediction limit, and the estimated probability of being a YUSHo patient (criterion 3), and by applying these three criteria to potential victims who had not been diagnosed as having Yusheso according to the current diagnostic criteria.

TL;DR: Although the blood levels of polychlorinated biphenyls (PCBs) and dioxins are now decreasing in Yusho patients, they still cause abnormal discharge from the eye and the significant relation between the increase in ocular discharge and the level of poly chlorinated dibenzofurans (PCDFs) in the blood is currently considered strong.

TL;DR: A novel compound, N -(4-pyridoxylmethylene)- l -serine (PYSer), is designed as a cosmetic material with a structure similar to a biological iron sequestering protein to suppress skin photoaging, especially wrinkle formation.

TL;DR: Blood analyses, blood chemistry and urine values in YUSHo patients were not significantly different from those in the control group 34 years after the Yusho incident, and exposure to PCBs and the related organochlorine compounds should be avoided.

TL;DR: The prevalence of oral pigmentation still remains high even after 35 years, and PCDFs may be responsible for the presence of Oral pigmentation.

TL;DR: Organs of the respiratory system remain affected by Yusho 35 years after the incident, whereas little effect on cardiac and renal systems is observed.

TL;DR: This is the first study to report on the relationship between blood concentration of PCDFs and blood chemistry, alpha-fetoprotein or hepatitis B surface antigen in Yusho and found three items of the blood chemistry analysis were significantly related to the total PCDF level using three-way analysis of variance (ANOVA).