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Yiru Xu
Researcher at University of Michigan
Publications - 24
Citations - 1054
Yiru Xu is an academic researcher from University of Michigan. The author has contributed to research in topics: Tyrosine phosphorylation & Photoaging. The author has an hindex of 15, co-authored 21 publications receiving 928 citations.
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Journal ArticleDOI
Quercetin inhibits UV irradiation-induced inflammatory cytokine production in primary human keratinocytes by suppressing NF-κB pathway
Fabiana T. M. C. Vicentini,Tianyuan He,Yuan Shao,Maria José Vieira Fonseca,Waldiceu A. Verri,Gary J. Fisher,Yiru Xu +6 more
TL;DR: The ability of quercetin to block UV irradiation-induced skin inflammation is mediated, at least in part, by its inhibitory effect on NF-κB activation and inflammatory cytokine production.
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Oxidative inhibition of receptor-type protein-tyrosine phosphatase κ by ultraviolet irradiation activates epidermal growth factor receptor in human keratinocytes
TL;DR: In this article, the authors showed that epidermal growth factor receptors (EGFRs) activation by UV irradiation results from oxidative inhibition of receptor type PTP-κ.
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Receptor-type Protein-tyrosine Phosphatase-κ Regulates Epidermal Growth Factor Receptor Function *
TL;DR: It is reported here that receptor-type protein-tyrosine phosphatase-κ (RPTP-κ) dephosphorylates EGFR and thereby regulates its function in human keratinocytes and is a key regulator of EGFR tyrosine phosphate phosphorylation and function in humans.
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Ultraviolet (UV) light irradiation induced signal transduction in skin photoaging
Yiru Xu,Gary J. Fisher +1 more
TL;DR: The role of UV-induced signaling in the mechanism of premature skin aging (photoaging) is described, with emphasis on membrane-initiated, non-nuclear signaling events.
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Epidermal Growth Factor Receptor Is a Critical Mediator of Ultraviolet B Irradiation-Induced Signal Transduction in Immortalized Human Keratinocyte HaCaT Cells
TL;DR: Investigation of the function of EGFR in mediating UVB-induced signal transduction in human skin keratinocyte HaCaT cells demonstrates that EGFR is required forUVB-mediated induction of multiple signaling pathways that are known to mediate tumor formation in skin.