Journal of drug discovery and therapeutics 

About: Journal of drug discovery and therapeutics is an academic journal published by CAB PUBLISHER. The journal publishes majorly in the area(s): Drug delivery & Controlled release. It has an ISSN identifier of 2320-4230. Over the lifetime, 283 publications have been published receiving 461 citations.

Antioxidant activity of herbal plants: a recent review

Abstract: Antioxidants or inhibitors of oxidation are compounds which retard or prevent the oxidation and in general prolong the life of the oxidizable matter. Majority of the diseases/disorders are mainly linked to oxidative stress due to free radicals. The free radicals (oxidants) are species with very short half-life, high reactivity and damaging activity towards macromolecules like proteins, DNA and lipids. In general, the reactive oxygen species circulating in the body tend to react with the electron of other molecules in the body and these also effect various enzyme systems and cause damage which may further contribute to conditions such as cancer, ischemia, aging, adult respiratory distress syndromes, rheumatoid arthritis etc. A plant-based diet protects against chronic oxidative stress-related diseases. Dietary plants contain variable chemical families and amounts of antioxidants. It has been hypothesized that plant antioxidants may contribute to the beneficial health effects of dietary plants. This review presents some information about the antioxidant/antiradicals and their role in our body and also their presence in spices and herbs. Key words: Antioxidants, Free radicals, Herbal Plants

A review on bilayer tablets

Abstract: Over the past 30 years stated that the expense and complications involved in marketing new drug entities have increased, with concomitant recognition of therapeutic advantages of controlled drug delivery, greater attention has been focused on development of sustained or controlled release drug delivery systems. Bilayer tablet is new era for the successful development of controlled release formulation along with various features to provide a way of successful drug delivery system. Controlled release dosage forms have been extensively used to improve therapy with several important drugs. Use of bilayer tablet is a very different aspect for anti-inflammatory and analgesic. Bi-layer tablet is suitable for sequential release of two drugs in combination, separate two incompatible substances and also for sustained release tablet in which one Layer is immediate release as initial dose and second layer is maintenance dose. Bilayer tablet is improved beneficial technology to overcome the shortcoming of the single layered tablet. In the case of bilayered tablets drug release can be rendered almost unidirectional if the drug can be incorporated in the upper nonadhesive layer its delivery occurs into the whole oral cavity. KEYWORDS: Bilayer tablet, GMP requirement for bi-layer tablets, Various tablet presses, RoTotab push technology, DUROS technology.

Medical benefits of apium graveolens (celery herb)

Abstract: Celery (Apium graveolens) is an alimentary herb as well as a special medicinal plant. Celery leaves are used for spicing up foods and drinks such as cocktails. It contains vitamins A, B1, B2, B6, C, E, K, P and minerals such as iron, calcium, phosphorus, magnesium and zinc. Vitamin C contained by celery strengthens the immunologic system and at the same time makes the body more resistant against new diseases. Calcium, potassium and magnesium act towards the same goal, straightening the body. Along with magnesium, iron is effective in alleviating the effects of anemia. Celery has the ideal quantities of iron and magnesium to stop oncological diseases from progressing. The juice extracted from the petioles can be used for edema, rheumatic tendencies, gout, flatulence, chronic pulmonary catarrh, tendencies toward overweight and lack of appetite. It is a strong diuretic, and is used as a urinary antiseptic, mainly because of the volatile oil apiol. Celery can be helpful in treating skin problems, when it is used raw, or prepared as tea. Celery seed decoction is used for bronchitis, rheumatism, and as a sedative. Seeds are also used as a blood purifier, and are very helpful in treating arthritis. Oil extracted from the root can restore sexual potency affected by illness. KEY WORDS: Apium graveolens, Celery, Antioxidants, Seeds, Liver

A recent review on anticancer herbal drugs

Abstract: Cancer is a leading cause of mortality in the world and it’s the cause of more than 20% of all deaths. Plants are one of the main sources of biologically active ingredients. In the last few decades research has been focused on the use of natural products for cancer therapy. This is due to serious side effects associated with chemotherapy and radiation therapy, many cancer patients seek alternative complementary methods of treatment. In the present review an attempt has been made to study the plants that have been used in the treatment of cancer. KEYWORDS: Cancer, Phytochemical constituents, anticancer plants etc.

Emulgel: a combination of emulsion and gel

Abstract: Dermatological products applied to skin are diverse in formulation and range in consistency from liquid to powder but the most popular products are semisolid preparation. Emulgels have emerged as one of the most interesting topical delivery system as it has dual release control system i.e. gel and emulsion. When gel and emulsion are used in combined form the dosage form are referred as emulgel. Emulgels are having major advantages on novel vesicular systems as well as on conventional systems in various aspects. The emulgel for dermatological use has several favorable properties such as being thixotropic, greaseless, easily spreadable, easily removable, emollient, non-staining, water-soluble, longer shelf life, bio-friendly, transparent & pleasing appearance. Various permeation enhancers can potentiate the effect, so emulgels can be used as better topical drug delivery systems over present systems. The use of emulgels can be extended in analgesics and antifungal drugs. KEY WORDS: Emulgel, Skin, Gel, Emulsion, Hydrophobic Drugs