Showing papers in "Journal of Genetics and Genomics in 2022"

TL;DR: In this article , the authors reviewed the biology of SIRT3, SIRT4, and SIRT5, known as the mitochondrial sirtuins due to their localization in the mitochondrial matrix.

TL;DR: In this article , the authors summarized the function and regulation of these enzymes reported in three major crops-rice, maize, and wheat, also in the model plant Arabidopsis, and highlighted their application in improving NUE of crops via manipulating N assimilation.

TL;DR: A review of the current literature regarding physiological and biochemical responses to both high light stress and fluctuating light stress can be found in this article , where the authors suggest that state transitions and cyclic electron transport are the main adaptive mechanisms for mediating fluctuating low light stress in plants.

TL;DR: In this article , a genome-wide association study (GWAS) revealed that the transcription factor OsbZIP60 is a vital regulator of rice grain chalkiness, and the role of the unfolded protein response (UPR) pathway in the formation of grain chalkyness in rice.

TL;DR: In this article , the grain length QTL GL10, encoding MADS56, has been shown to positively regulate grain length and grain weight in rice, and an allelic variation of NIL-gl10, containing an ∼1.0-kb deletion in the first exon that abolishes its transcription, results in shorter grain length, lower grain weight and delayed flowering in gl10 plants.

TL;DR: In this paper , a review of recent studies of the mechanism of PM H+-ATPases in response to abiotic stresses in plants, such as salt and high pH, temperature, drought, light, macronutrient deficiency, acidic soil and aluminum stress, as well as heavy metal toxicity, is presented.

TL;DR: In this paper , an analysis of F1 diallel crosses showed that strong heterosis widely exists in hybrids of diverse germplasms, and inter-subspecific hybrids often display higher heterosis.

TL;DR: In this paper , it was shown that S-nitrosylation of Cys-374 in the Arabidopsis RGA protein inhibited its interaction with the F-box protein SLY1, thereby preventing its proteasomal degradation under salinity condition.

TL;DR: In this article , a review of preclinical studies on the biochemical function of TNF-α and its intracellular downstream signaling mechanisms through its receptors is presented, where the authors extensively discuss its functions in regulating inflammation, cell death, and fibrosis of liver cells in the pathogenesis of NASH, and the molecular mechanism that TNFα expression is regulated by NF-κB and other upstream master regulators during NASH progression.

TL;DR: In this article , the authors summarized the current understanding on the phytohormone jasmonate signal initiation, perception and regulation, and highlighted the distinctive characteristics in different lineages of plants.

TL;DR: In this article , an unbiased transcriptomic analysis was performed on human retinal microvascular endothelial cells (HRECs) and revealed a pivotal role of EMC1 in the β-catenin signaling pathway.

TL;DR: In this article , the authors provide updated information on hydrogen sulfide (H2S) action in regulating ROS-dependent redox homeostasis and signaling, and also discuss the mechanisms of H2S-dependent regulation in the context of oxidative stress elicited by environmental cues.

TL;DR: Wang et al. as mentioned in this paper developed a panel of 465 causative genes for 596 early onset, relatively high incidence, and potentially actionable severe inherited diseases in their Newborn Screening with Targeted Sequencing (NESTS) program to screen 11,484 babies in 8 Women and Children's hospitals nationwide in China retrospectively.

TL;DR: Pan-genomics can encompass most of the genetic diversity of a species or population and has proved to be a powerful tool for studying genomic evolution and the origin and domestication of species, and for providing information for plant improvement as discussed by the authors .

TL;DR: In this article , the authors summarized the current knowledge of plant immunity and outline existing and new strategies for disease resistance improvement in crop plants and discuss existing challenges in this field and suggest directions for future studies.

TL;DR: In this article , the authors introduce the concept of ferroptosis, characterized by the features of non-apoptotic, iron-dependent, and overwhelmed accumulation of lipid peroxides, and the underlying regulated circuits are considered to be pro-ferroptotic pathways.

TL;DR: In this paper , a detailed description of the key genes involved in the formation of grain appearance, and the major environmental factors affecting chalkiness are discussed, together with the integration of current knowledge on valuable genes to enable accurate breeding strategies for generation of rice grains with superior appearance quality.

TL;DR: In this article , it was shown that active DNA demethylation is required for MAMP-triggered immunity to bacterial pathogens and that flg22-induced demethylization contributes to immune responses.

TL;DR: In this paper , the role of three Arabidopsis nucleolar proteins HDT1, HDT2, and HDT3 in fertility and transcription of rDNAs and rRNA processing-related genes through histone acetylation was highlighted.

TL;DR: In this article , the evolutionary causes for the different tempos of sex chromosome evolution were investigated in the female genomes of 12 paleognathous species and reconstructed the phylogeny and the evolutionary history of their sex chromosomes.

TL;DR: In this article , the authors systematically analyzed the heading date, photoperiod sensitivity (PS), and agronomic traits of eight homozygous lines with various combinations of Hd1, Ghd7, and DTH8 alleles in the prr37 background under long-day and short-day (SD) conditions, respectively.

TL;DR: In this paper , the authors review recent work on the molecular mechanism by which parental experience can affect future generations and the importance of soma-to-germline signaling for transgenerational inheritance.

TL;DR: In this paper , the bZIP transcription factor APIP5, a negative regulator of cell death and rice immunity, directly binds to the OsPHT4 promoter to regulate putrescine-derived phenolamide metabolites.

TL;DR: In this article , the role of HAND1 in the regulation of cholesterol metabolism in human trophoblasts was uncovered. But the role was not investigated in the human placenta.

TL;DR: In this article , the integrative role of the gut microbiome and microbial metabolites in acute myocardial infarction (AMI) remains unclear, and the authors analyzed the microbial community through 16S rRNA gene sequencing and shotgun metagenomic sequencing and measured fecal short-chain fatty acids and circulating choline pathway metabolites among 117 new-onset AMI cases and 78 controls.

TL;DR: In this article , the authors used label-free quantitative proteomics to map 2027 proteins of Synechocystis sp. PCC6803, a model cyanobacterium, to different subcellular compartments and generate a proteome atlas with such information.

TL;DR: In this paper , the are2 mutants accumulate excessive amounts of (p)ppGpp, which correlate with lower levels of photosynthetic proteins and higher amino acid levels, suggesting that are2 genetically interacts with ABC1/Fd-GOGAT.

TL;DR: Wang et al. as mentioned in this paper profiled the testicular single-cell transcriptomes of Guanzhong black pigs at the age of 7, 30, 60, 90, and 150 days.

TL;DR: In this paper , the authors provide an overview of recent progress and current challenges of Treg cell-based therapies and describe the new strategies for engineering Treg cells used in preclinical studies.

TL;DR: In this article , the authors found that Derlin-1 and TER94/VCP/p97 components of the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway restrain intestinal stem cell proliferation to maintain intestinal homeostasis in adult Drosophila.