Showing papers in "Journal of Investigative Dermatology in 1978"

TL;DR: The findings indicate that the responses induced by substance P were mainly mediated by histamine released from the dermal mast cells, and that substance P is a potent histamine liberator in human skin.

TL;DR: The effects of prolonged occlusion on the normal microbial skin flora, pH, transepidermal water loss (TEWL) and carbon dioxide emission rate (CDER) were studied.

TL;DR: Human epidermal keratinocytes may be isolated in high yield from 0.1 mm keratotome sections of adult skin by short-term trypsin release and subcultured on collagen gels following dispersion bytrypsin and EDTA.

TL;DR: It is postulated that the capacity of some of these agents to inhibit leukocyte chemotaxis may account, in part, for their efficacy in inflammatory skin diseases such as acne vulgaris.

TL;DR: Type IV collagen was localized ultrastructurally to the basal lamina part of the basement membrane zone using specifically purified antibodies produced by immunizing rabbits with a basement membrane collagen obtained from a transplantable mouse tumor.

TL;DR: This paper defines these cells immunologically and functionally and supports the concept that Langerhans cells are closely related to cells from the monocyte-macrophage-histiocyte series, including the capacity to present immunologically relevant antigen to the T lymphocyte and to cause proliferation to allogeneic T lymphocytes in mixed leukocyte reactions.

TL;DR: The visual determination of epidermal healing correlated well with the histologic studies of surface re-epithelialization and wounds healed 40% faster when occluded with polyethelene film and topical triamcinolone acetonide treatment delayed healing.

TL;DR: Observations suggest that dicarboxylic acids could be used in the treatment of people with hyperpigmentary disorders by acting as competitive inhibitors of tyrosinase.

TL;DR: The combined treatment considerably decreases the total energy of UVA required for PUVA alone; it accelerates the response of psoriasis to PUVA; and it is effective in the small group of patients who have to be considered PUVA failures, therefore more effective than PUVA.

TL;DR: The quinone intermediates resulting from tyrosinase-mediated oxidation of tyrosine were evaluated as sulfhydryl reagent inhibitors of purified calf thymus DNA polymerase alpha to determine which of these might be cytotoxic.

TL;DR: The glycosphingolipids and ceramides in the stratum corneum which contain high proportions of long chain saturated and 2-hydroxy fatty acids with high melting points appear well-suited to withstand wide changes in temperature, ultraviolet radiation and atmospheric oxidation that may occur within the environment of the skin surface.

TL;DR: The role of mitosis in the increase in the epidermal melanocyte population following repeated ultraviolet (UV) irradiation has been studied in C57B1 mice and it is indicated that cell division during the irradiation period can account for the total rise in the number of melanocytes.

TL;DR: Statistical analyses of mast cell counts indicate that the hypertrophic scar contains significantly greater numbers of mast cells than the other tissues studied and mature scars from deep thermal injuries are indistinguishable.

TL;DR: It is postulated that a decrease in the cyclic AMP/cyclic GMP ratio in psoriatic leukocytes, similar to the imbalance of these 2 cyclic nucleotides found in the lesional epidermis of psoriasis, might be the cause of their enhanced chemotactic and phagocytic activities.

TL;DR: Evidence was obtained that the inhibitor formed a complex with both dithiothreitol-activated papain and enzymatically inactive mercuripapain, and yielded a highly specific anti-inhibitor serum.

TL;DR: It is suggested that deposits of immunoglobulin and complement in the superficial cutaneous microvasculature can be found in a wide spectrum of vasculitis syndromes, and that erythema multiforme is mediated by the deposition of immune reactants in these vessels.

TL;DR: The dermal mononuclear cell infiltrates of psoriatic lesions were characterized by receptors for sheep erythrocytes, C3b receptors, macrophages and B-lymphocytes and C3d receptors, using hemadsorption to cryostat sections in a closed chamber.

TL;DR: The chemoattractant properties of different comedonal components for human PMN were analyzed in an effort to evaluate the potential significance of these substances in stimulating the chemotactic response of PMN in the initial phases of inflammatory acne.

TL;DR: The UV sensitivity of Cockayne's syndrome strains is not related to abnormal DNA excision repair, at least to the extent that this repair process is reflected by rates of ultraviolet light-induced unscheduled DNA synthesis.

TL;DR: In this paper, skin fibroblasts from the shoulder and lower extremities of normal individuals, as well as from patients with pretibial myxedema (PTM) were grown in culture.

TL;DR: The data show that human keratin has the same heterogeneity which was observed previously in cow epidermis, and this was further confirmed by studying the polypeptide chain content of prekeratin from a large number of lesions showing benign epidermal hyperplasia, where considerable variation in composition was observed.

TL;DR: Dopamine administration at a daily dose of 600 mg/kg resulted in a 48% increase in survival of treated mice as compared to non-treated controls, and it was postulated that the inhibition of a DNA polymerase might be the site of action of these novel antitumor agents.

TL;DR: Data indicate that the changes which are observed in the structural proteins during normal keratinization are not seen in involved psoriasis, and similar electrophoretic patterns with stratum corneum proteins from patients with other keratinizing disorders are found.

TL;DR: Polyamine levels were higher in involved than in uninvolved epidermis and the activities of the polyamine biosynthetic enzymes from biopsies of involved and uninvolved psoriatic epider Mis and normalEpidermis were higher than expected.

TL;DR: Results show that polyamine biosynthetic enzyme activity precedes the delayed increase in epidermal DNA synthesis following ultraviolet light exposure.

TL;DR: The data suggest that in active psoriasis serum factors may be coated on the lymphocyte surface membrane which may be responsible for blocking of specific receptor for sheep erythrocytes and/or interfere with T lymphocyte function.

TL;DR: In one-way mixed lymphocyte responses to pooled allogeneic stimulator lymphocytes, peripheral blood mononuclear cells from psoriatic subjects show suppression, the mean stimulation index was 55% of that of normal (p less than 0.01).

TL;DR: Adenylate cyclases of involved skin from psoriatic patients exhibit a markedly diminished response to epinephrine while at the same time exhibiting a markedly enhanced response to histamine, which precludes the possibility that the unresponsiveness toEpinephrine can be due to a generalized inability of the epidermal psoriats to make a functioning cell membrane.