Showing papers in "Laboratory Investigation in 1976"

TL;DR: The initial, early, and established lesions are sequential stages in gingivitis and they, rather than the advanced lesion which is manifest clinically as periodontitis, make up the major portion of inflammatory gingival and periodontal disease in humans.

TL;DR: It was shown that immunohistochemical demonstration for the above mentioned antigens, but not for complement, was feasible, and an optimal period of digestion could be sought to obtain the best result for a specific antigen.

TL;DR: The results indicate that nonciliated cells divide and the sister cells may form new ciliated and nonCiliated cells in the terminal bronchiolar epithelium, which can act as progenitor cells for the terminal Bronchiolars.

TL;DR: During the period of active resynthesis of elastin, small clumps of microfibrils and elastic fibrils were visible by electron microscopy within grooves on the surface of septal connective tissue cells in the lungs.

TL;DR: A distinct arterial lesion was observed in the large abdominal muscular arteries in three autopsied patients and may have been induced by immune complexes and that local arterial medial degenerative changes predispose the involved arteries to immunologic injury.

TL;DR: The visceral glomerular epithelium of rats made nephrotic by daily injections of puromycin aminonucleoside was examined from the time of onset of proteinuria to the time when many animals die in order to establish the chronology of the pathologic alterations which occur during the course of the disease.

TL;DR: Pulmonary changes induced by bleomycin were investigated in mice by using light and electron microscopy and by phospholipid analysis of the alveolar washings to support the view that the hyperactive type II cells secreted more surfactant in the early phase of the experiment.

TL;DR: Detailed base line data on visna infection is provided to suggest some of the mechanisms responsible for the persistence of infection and for the slowness and irregularity of disease occurrence, and form the basis for further experiments on the role of immunologic mechanisms in the pathogenesis of this slow infection.

TL;DR: Profound alterations in the dermal microvasculature and the closely related fixed tissue mast cells were observed in allergic contact dermatitis reactions to dinitrochlorobenzene and urushiol in man, and circumstantial evidence suggests that lymphocytes or their products or both may have been responsible.

TL;DR: Alveolar macrophage accumulation within proximal alveoli of alveolar ducts was the most readily detectable morphologic indicator of pulmonary damage, and although the brunt of ozone damage was borne by the centriacinar region, there was damage to cilia and increased ciliogenesis occurring in the trachea and larger conducting airways following exposure of 0.p.m. of ozone.

TL;DR: An experimental mouse model of autoimmune thyroiditis induced by neonatal thymectomy (between 2 and 4 days of age) is described, and possible mechanisms which may be involved in the present disease are discussed.

TL;DR: Serial sections revealed that vesicles may be contiguous from luminal to abluminal surfaces, thus providing facilitated transport pathways, and suggest that vESicular transport plays a role in the genesis of trauma-induced edema.

TL;DR: It is suggested that increased microfilaments are related to enhanced motility of invasive carcinoma cells in vivo and that decreased hemidesmosomes may be related to loss of cell to substratum or "anchorage" dependence of growth in malignant cells.

TL;DR: Several different ways in which suppression could modify the immune response to visna virus are suggested, including a reduced number of virus isolations from peripheral lymphoid tissue, presumably reflecting the lympholytic effect of treatment.

TL;DR: It is concluded that an enzyme system present in the involuting breast is capable of basement membrane hydrolysis and had a pH optimum.

TL;DR: The ultrastructural studies indicated that both preparations of complexes initially localized as electron-dense material in endothelial cell fenestrae and in the subendothelial space of the glomerular capillary loops and subsequently accumulated in the mesangial matrix between mesangials.

TL;DR: The tracer proteins, horseradish peroxidase and ferritin, placed in the trachea of guinea pigs were taken up by epithelial cells and transported to the extracellular space and this transport may be of importance in the late onset type of asthma.

TL;DR: The cytochemical localization of catalase and peroxidase in various sinusoidal cells of rat liver, i.e., in Kupffer cells, endothelial cells, and fat-storing cells has been investigated and the alkaline 3,3'-diaminobenzidine technique reveals distinct "catalase-positive particles" in all three cell types.

TL;DR: As was found previously for albumin, glomerular barrier function for IgG and catalase depends upon the maintenance of normal blood flow conditions, and it is proposed that such conditions impose functional restrictions may be mediated by molecular sieving phenomena during normal ultrafiltration across the GBM.

TL;DR: Lower concentrations of saturated free fatty acids, within the range reported clinically in various diseases, caused a marked inhibition of chemotaxis, and these functional disturbances were associated with ultrastructural alterations.

TL;DR: The results suggest that there are at least two morphogenetic processes leading to emphysema, one is the coalescence of fenestrations leading to destruction of alveolar walls, and the other is a gradual remodeling of lung structure by mechanisms still to be defined.

TL;DR: Results confirm that CEA is a normal glycoprotein constituent of the epithelial cell of the human adult rectocolonic mucosa, synthesized and discharged by this cell.

TL;DR: The observations indicated that the removal of large latticed complexes from the circulation by the hepatic mononuclear phagocyte system was decreased when reduced and alkylated antibodies were used for the preparation of immune complexes.

TL;DR: The conclusion is reached that this interval of hypertrophic response is a transition period characterized by an increasing rate of synthesis of contractile proteins overtaking a previously greater rate of mitochondrial synthesis.

TL;DR: This experimental model of Bence Jones nephropathy closely resembles the morphologic features of so-called "myeloma kidney" in man.

TL;DR: There was a nonuniform response with significant increase in nuclear labeling in the obstructed kidney in all zones at 24, 48, and 72 hours following obstruction with the exception of the inner medulla where the counts at 24 and 48 hours were not significantly different from sham-operated controls.

TL;DR: The present results lend further support to a concept that regards a pronounced amphiphilic (amphipathic) character to be responsible for the lipidosis-inducing action of various cationic compounds.

TL;DR: Acute viral infections of the inner ear were produced in neonatal hamsters and selective vulnerability of inner ear structures was demonstrated using a variety of viruses.

TL;DR: The results indicate that potassium depletion induces early increases in the formation of cell membrane phospholipid which correlate with specific morphologic changes in different zones within the kidney.

TL;DR: It would appear that the first stage of antiserum-induced demyelination in vitro is isolated, a stage which is now available for further study.