•Journal•ISSN: 0032-5422
Postepy biochemii
Polish Biochemical Society
About: Postepy biochemii is an academic journal published by Polish Biochemical Society. The journal publishes majorly in the area(s): Biology & Medicine. It has an ISSN identifier of 0032-5422. It is also open access. Over the lifetime, 1007 publications have been published receiving 8563 citations.
Topics: Biology, Medicine, Gene, Signal transduction, Chemistry
Papers published on a yearly basis
Papers
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TL;DR: It seems to be likely that BER pathways are essential for genomic repair and stability in living cells.
Abstract: Damage to DNA bases resulting from deamination, oxidation, and alkylation is mainly repaired by base-excision repair. BER is initiated by DNA glycosylases, which recognize damaged bases and excise them from DNA by hydrolyzing the N-glycosidic bond between the base and the sugar phosphate backbone of DNA to generate an abasic site. Different human and E. coli DNA glycosylases have been cloned and characterized, each one with unique substrate specificity. Some of them additionally have AP lyase activity, which enables them to cleave the bond between the sugar and phosphate 3' to the damaged site. BER consist of two repair pathways (short or long) in which one or more nucleotides are introduced respectively. In conclusion, it seems to be likely that BER pathways are essential for genomic repair and stability in living cells.
276 citations
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TL;DR: New DNA polymerases that possess very unusual functions have been identified that are able to perform translesional synthesis, take part in somatic hypermutation and prevent some cancers.
Abstract: Knowledge about eukaryotic DNA polymerases has increased considerably during recent years. Much have been learnt about both the structures and the functions of "classical" DNA polymerases alpha, beta, delta, epsilon and gamma. New DNA polymerases that possess very unusual functions have been identified. They are able to perform translesional synthesis, take part in somatic hypermutation and prevent some cancers. Much attention has also been devoted to the role of 3'-->5' exonuclease activity in the accuracy of DNA synthesis. On the other hand, it have been shown that there are also negative aspects of the activity of DNA polymerases. Lack of some DNA polymerases or even their altered functions may lead to carcinogenesis and accelerate the process of ageing.
224 citations