Showing papers in "Seminars in Arthritis and Rheumatism in 1986"

TL;DR: Thirty-two toxic oil syndrome patients were selected because they presented with scleroderma-like changes and were observed during the first 36 months of evolution of the disease, and biopsy studies during this stage showed fibrosis and obliterating arteriopathy.

TL;DR: Ninety-two percent of nephropathy and 62% of NS episodes resolved or improved after corticosteroid therapy, and Anti-RNP and serum complement were not helpful in predicting nephritis.

TL;DR: This discussion will focus on the pharmacology, toxicity, and clinical application of four drugs that have received most of the attention in the treatment of the rheumatic diseases: azathioprine (AZA), cyclophosphamide (CTX), chlorambucil.

TL;DR: The discovery of D-penicillamine and its uses in medicine, including dosages, clinical and laboratory responses, patterns of adverse side effects or toxicity, drug-induced autoimmune diseases, indications and contraindications, and the monitoring and management of patients are reviewed.

TL;DR: A syndrome that has been termed “palmar fasciitis and arthritis” has been reported to occur in association with ovarian adenocarcinoma, which differs from the usual case of shoulder-hand syndrome in that the progression and extent of rheumatic disease are much more dramatic.

TL;DR: The association of CF with an episodic form of arthritis is confirmed and it is reported that a subgroup of these patients later develop persistent synovitis with progressive asymmetric, erosive disease.

TL;DR: The association of these two diseases, which share some pathogenetic features characterized by a predominant IgA response, is probably not fortuitous and four cases of this association are reported.

TL;DR: Except for more frequent episodes of serositis and less prevalent neuropsychiatric manifestations and hepatosplenomegaly, no distinguishing features were found in MCTD patients with myocarditis compared with those without myocardial involvement.

TL;DR: Tolerance seemed to develop among most patients whose AST levels became elevated in that the elevation subsided, remained essentially unchanged, or became only slightly higher despite continued therapy.

TL;DR: Both treatment groups showed statistically significant improvement from baseline in measures of joint tenderness and swelling, morning stiffness, right- and left-hand grip strength, time to walk 50 feet, and the opinions of the observers and the patients.

TL;DR: Patients with prior gold-induced proteinuria should be observed more carefully, but tissue typing is not recommended as proteinuria is reversible, and penicillamine can be restarted or maintained in these patients if the RA has responded favorably to the drug.

TL;DR: This 1-year multicenter double-blind study compared the efficacy and safety of Oxaprozin with those of ibuprofen in 159 patients with active rheumatoid arthritis (RA).

TL;DR: At most evaluations, comparable significant changes from baseline values indicative of improvement were noted in the four principal efficacy measures among patients in both treatment groups.

TL;DR: The unusual nature of this case prompted the review of the association of SLE to AIL, where the patient had longstanding connective tissue disease, starting as mixed connective tissues disease (MCTD) which evolved into classical SLE, and ultimately died from AIL.

TL;DR: Oxaprozin is no more likely than other NSAIDs to increase the risk of gastrointestinal, hematologic, or renal toxicity among elderly patients with RA or OA, and the incidence of these forms of toxicity varies depending on the underlying disease.

TL;DR: A retrospective review of the spectrum of disease, clinical characteristics, diagnostic evaluation, and outcome of 16 patients with cerebral angiograms consistent with cerebral arteritis finds that cerebral vasculitis is uncommon and the frequency of defined cases is reduced by the lack of angiographic or pathologic confirmation.

TL;DR: During the double-blind period, both groups showed statistically significant improvement in almost all efficacy measurements, including observer's and patient's opinion, pain intensity, activity impairment, morning stiffness, time to walk 50 feet, and knee flexion and extension.

TL;DR: The current state of knowledge about myositis-related autoantibodies is summarized, including characterization of the antigens, epidemiology, clinical significance, and the clues these autoantIBodies may provide concerning the etiology and pathogenesis of the disease.

TL;DR: Ninety-seven patients with ankylosing spondylitis entered a 6-month multicenter, double-blind study that compared the efficacy and safety of Oxaprozin with those of indomethacin.

TL;DR: It has been hypothesized that the dual metabolism of Oxaprozin, involving both glucuronidation and oxidation, may provide an added safety factor in patients in which one of the two metabolic pathways is impaired.

TL;DR: Fifty patients with acute gouty arthritis entered into an 8-day multicenter open study designed to evaluate the efficacy and safety of Oxaprozin, a new nonsteroidal antiinflammatory drug (NSAID).

TL;DR: The efficacy and safety of Oxaprozin and aspirin were evaluated and compared in the treatment of 202 patients with active rheumatoid arthritis in a 4-week double-blind, multicenter study.