Showing papers in "Seminars in Arthritis and Rheumatism in 2002"

TL;DR: The understanding of the pathogenesis of osteonecrosis is now much better defined and skeletal scintigraphy and magnetic resonance imaging have enhanced diagnosis greatly, helping the physician determine which patients are at risk for oste onecrosis, facilitating early diagnosis and better treatment options.

TL;DR: By mitigating the activities of proinflammatory mediators and pain producing neuropeptides released by activated synovial cells, HA may improve the symptoms of knee osteoarthritis (OA) by redressing this deficiency.

TL;DR: The clinical significance of finding aPL antibodies in patients with viral infections remains unknown and in some patients, these antibodies may be transient and disappear within 2 or 3 months, while in other susceptible individuals, they may persist and raise the question of whether infections may trigger the development of aPL antibody in autoimmune diseases.

TL;DR: This study comprehensively reviews the literature related to relapsing polychondritis and concludes that the pathogenesis and optimal therapeutic approach to patients with RP is poorly understood.

TL;DR: Spontaneous pyogenic vertebral osteomyelitis in nondrug users is a disease that affects mainly older patients suffering underlying medical illnesses, and the physician should be alert to the possibility of this condition in patients with back or neck pain.

TL;DR: HSP is generally benign and self-limited in children and more severe in adults, whereas in children, the frequency of severe renal manifestations or renal insufficiency during the course of the disease was significantly reduced compared with adults.

TL;DR: This study shows a significant overlap between FM and PTSD, according to the currently accepted diagnostic criteria for each, which is significantly higher than in the general population.

TL;DR: The additive effect of various genes may account for the development of RA and its clinical severity and the protection against RA recently was confirmed in both UK and northwest Spanish populations.

TL;DR: Autoimmune disorders occur in 4% to 19% of patients receiving IFN-alpha, though SLE-like syndromes are only seen in 0.15% to 0.7%.

TL;DR: The cyclooxygenase (COX)-2 specific inhibitors (coxibs) have been developed in order to improve the GI safety and tolerability profile of therapy with NSAIDs, and have been shown to have efficacy similar to that of nonselectiveNSAIDs, but are associated with significantly fewer endoscopic ulcers.

TL;DR: C-spine involvement in DISH is a recognized cause of various clinical manifestations involving the pharynx, larynx and the esophagus and should alert the clinicians for possible complications, at times severe, during invasive procedures in the neck region and as a consequence of trauma.

TL;DR: Patients who are at risk for adverse renal events should be monitored with the same caution when receiving coxibs as when receiving treatment with nonselective NSAIDs.

TL;DR: The long-term prognosis of the SLS patients was reasonable, highlighting the importance of establishing a correct diagnosis and in particular differentiating it from fibrosing lung disease.

TL;DR: It is suggested that renal involvement in Behçet's disease is more frequent than has been recognized, although it is most often mild in nature.

TL;DR: The HLA-B27 antigen is not only important for PsSpA susceptibility, but also determines some clinical features, and was associated with earlier age of psoriasis and arthritis onset, bilateral sacroiliitis, and male gender.

TL;DR: The OIT may precipitate SLE or APS, and preventive anti-inflammatory therapy should be considered in women with SLE, in addition to heparin and/or anti-aggregant therapy in patients with asymptomatic anti-phospholipid antibodies or prior thrombotic events.

TL;DR: Although SCI is a rare infection in healthy adults, it should be considered in the differential diagnosis of a painful sternoclavicular joint, and Prompt diagnosis and appropriate treatment of SCI results in excellent outcome in most cases.

TL;DR: In this study, extensive axial involvement (bilateral sacroileitis and syndesmophytes), and the HLA-DR13 antigen were the best predictors for the appearance of uveitis.

TL;DR: The genotypes M694V/M694V and M694v/V726A have a severe clinical course in Arab patients with FMF, whereas the M694I/M693I is associated with mild disease.

TL;DR: Idiopathic osteoporosis was the most frequent diagnosis of pre-menopausal osteoporeosis in patients referred to an outpatient rheumatology department and a family history of osteop orosis and hypercalciuria were factors frequently associated with this disorder.

TL;DR: Compared with hand involvement with SSc, foot involvement in SSc has a later onset and is relatively less frequent but can be disabling, and foot involvement with limited scleroderma was later than in diffuse SSc.

TL;DR: Although bone lesions in sarcoidosis may occur throughout the entire skeleton, axial involvement is rare, and pain frequently is present, and magnetic resonance imaging may be helpful in monitoring the response to treatment.

TL;DR: Although 5 of 6 studies showed a marked positive effect of vocational rehabilitation on work status, proof of the benefit of these interventions is limited, mainly due to methodologic differences and shortcomings.

TL;DR: There is no compelling evidence that the development of CSS in asthmatic patients receiving LTAs results from a direct drug effect, but it appears that tapering of corticosteroids in these patients unmasks the multiorgan manifestations of the disease.

TL;DR: Given the continued and growing number of patients at risk for parasitosis by virtue of their country of origin, travel habits, and an immunocompromised state, potential Parasitosis must be considered in patients undergoing evaluation for rheumatic complaints.

TL;DR: Innovative analytical methodologies will need to be developed to more effectively investigate complex interacting biopsychosocial dynamics at a person-centered level, including qualitative research, and multifactorial and multilevel techniques.

TL;DR: The cyclooxygenase (COX)-2-selective nonsteroidal anti-inflammatory drugs (NSAIDs; coxibs) were developed in order to reduce upper gastrointestinal (GI) side effects associated with traditional nonselective NSAIDs as mentioned in this paper.

TL;DR: Results indicate that gene transfer of p53 may be clinically useful for the management of RA and indicate that p53 mutations can and do occur in RA synovial tissue samples derived from a subset of RA patients.

TL;DR: The clinical and laboratory features of SLE in patients with systemic lupus erythematosus and pure red cell aplasia are similar to SLE patients without PRCA with the exception of a decreased frequency of pleuritis.

TL;DR: Although chronic HCV infection may mimic the main clinical, histologic and immunologic features of primary SS, patients with HCV-related SS showed some differentiated characteristics, including a predominant Th2 pattern and a higher frequency of cryoglobulinemia and hypocomplementemia ( features closely related to HCV).