Showing papers in "Transfusion Medicine Reviews in 2001"

TL;DR: Examination of storage-related changes in RBC shape in relation to posttransfusion survival and RBC function is reexamine, speculating on a possible association between storage- related changes and adverse clinical consequences of transfusing blood.

TL;DR: Variation in geographic/ethnic distribution of allele frequencies is discussed, along with the confusing nomenclatures currently in use.

TL;DR: The negative effect of short-term temporary deferrals on future blood donations was reviewed and age, gender, and hemoglobin deferral patterns are described.

TL;DR: This review highlights the rationale for, design of, and recent preclinical and clinical trials with receptor-modified T lymphocytes.

TL;DR: This review will summarize what is and what is not known about syphilis testing in blood donors and will discuss the need for further research to answer these questions.

TL;DR: The combined clinical and laboratory data strongly support the contention that HGV is not a hepatotropic virus and that this virus was inappropriately named hepatitis G.

TL;DR: Dombrock expression is developmentally regulated during erythroid differentiation and occurs at highest levels in the fetal liver and Homology studies suggest that the Dombrock molecule is a member of the adenosine 5'-diphosphate (ADP)-ribosyltransferase ectoenzyme gene family.

TL;DR: Recombinant erythropoietin therapy has not been widely adopted because it does not consistently reduce the need for red blood cell transfusions in very low-birth weight preterm infants.

TL;DR: The structure and function of the PIGA gene is described, the lessons learned from the analysis of PigA gene mutations are summarized, the impact of mouse models on the current understanding of the human disease is reviewed, and the possible pathogenesis of PNH is discussed.

TL;DR: Success in making plasma products safe from recognized and potential pathogens has dramatically increased societal pressures to produce a zero-risk, plasma-derived protein therapy, however, past improvements and low theoretic risks for future pathogen contamination have increased product cost.

TL;DR: A comprehensive review of DHTRs and DSTRs, the role of complement and cytokines in these reactions, and the phenomenon of bystander hemolysis is provided.

TL;DR: The various mechanisms that contribute to the viral safety of therapeutics prepared from human blood plasma are examined and the basic principles behind the 2 most important mechanisms for viral safety, inactivation, and removal are discussed.

TL;DR: The expression of PrPc on human and animal blood cells and its potential functional roles are examined and studies of transfusion-mediated transmission of TSE infectivity in animals are discussed.

TL;DR: Preliminary studies suggest that injection of genetically modified autologous DCs may be capable of generating anti-tumor immune responses in patients with cancer, and rationale to further evaluate this approach in patients is provided.

TL;DR: The first clinical trial using intravenous immune globulin (IV1G) to treat immune (idiopathic) thrombocytopenic purpura (ITP) was reported in this article.

TL;DR: The origin of vCJD, the pathophysiologic questions surrounding this condition, and the latest diagnostic tests and research are reviewed, and reasons for the discrepancy between theoretic and actual transmission for CJD and the body of evidence provided by look-back studies are examined.