Showing papers in "Trends in Biotechnology in 2023"

TL;DR: A series of spectacular scientific discoveries and technological advances in the second half of the 20th century have provided the basis for the ongoing genome editing revolution as discussed by the authors , and the elucidation of structural and functional features of DNA and RNA was followed by pioneering studies on genome editing: molecular biotechnology was born.

TL;DR: In this article , the authors demonstrate how ML methods have been applied so far in bioprocess development, especially in strain engineering and selection, bi-process optimization, scale-up, monitoring, and control of bi-rocesses.

TL;DR: In this article , the potential of microalgae replacing soy protein, fish oil, and palm oil and being used as cell factories in modern industrial biotechnology to produce designer feed, recombinant proteins, biopharmaceuticals, and vaccines is discussed.

TL;DR: In this article , the objectives of the Sustainable Development Goals and the European Green Deal related to achieving food security and sustainable development in European Union (EU) agriculture, taking the aforementioned threats into account.

TL;DR: In this article , a pre-amplification step is required to improve the sensitivity of CRISPR systems, complicating the operating procedure and limiting quantitative precision, and nonspecific collateral cleavage activity makes it difficult to realize multiplex detection in a one-pot reaction with a single Cas protein.

TL;DR: Biosensors are utilized in several different fields, including medicine, food, and the environment; a review of recent developments in biosensors for healthcare can be found in this paper .

TL;DR: In a permissive environment, stem cell derivatives can self-organize and reconstruct their native milieu, resulting in the creation of organ-like entities known as organoids as mentioned in this paper .

TL;DR: In this article , the authors discuss the different biological, technical, and mathematical tools for the analysis and control of bioprocess robustness, and discuss the main driving forces of this development are increasing demands on product purities and economic aspects.

TL;DR: The increasing popularity of gene editing in plants has prompted research on stakeholder views as mentioned in this paper , however, marketing challenges related to a lack of familiarity with the technology, labeling, and risk perception remain.

TL;DR: In this paper , a CRISPR/Cas9 gene technology is transported as RNA from transgenic roots to distal parts of unmodified grafted scion, where it is translated into proteins to induce heritable mutagenesis at desired loci.

TL;DR: The potential of Pichia pastoris to utilize other C1 feedstocks -including CO2 and formate -was highlighted in this article , and new insights from the perspectives of synthetic biology and material science were proposed.

TL;DR: In this article , the authors review the emergence of the new field of organ-on-a-chip (OOAC) engineering, from the parent fields of tissue engineering and microfluidics.

TL;DR: In this article , the authors proposed an upcycling process via tandem chemical deconstruction and biological transformation for poly(ethylene terephthalate) waste open-loop management.

TL;DR: Metabolic engineering (ME) allows purposeful modification of cellular metabolic, regulatory, and signaling networks to achieve enhanced production of desired chemicals and degradation of environmentally harmful chemicals as mentioned in this paper , which has significantly progressed over the past 30 years through further integration of the strategies of synthetic biology, systems biology, evolutionary engineering, and data science aided by artificial intelligence.

TL;DR: In this paper , the authors discuss the contribution of electrobiotechnology to the realization of the SDGs, and discuss the potential of this technology for the sustainable development goals (SDGs).

TL;DR: Munsie et al. as discussed by the authors examined two topics (the possibility of consciousness and medical applications) and call on scientists, ethicists, and the media to represent brain organoid research and its ethical issues more accurately.

TL;DR: Huh et al. as mentioned in this paper showed that OOC can enable examination of drug toxicities and disease pathogenesis in reconstituted tissues, enabling a new era of drug discovery.

TL;DR: In this article , a review of intelligent synthetic biology-enabled biosensors (SBBs) is presented with the capability of computation, memory storage, and self-calibration.

TL;DR: In this article , a framework for developing synthetic biology solutions for the challenges of plastic pollution, coral bleaching, and harmful algal blooms is presented, which can augment the natural adaptive capacity of ocean biological systems to cope with the swiftness of humaninduced change.

TL;DR: In this article , a review gives an overview of these innovative strategies for manufacturing mesenchymal stromal cells (MSC-EVs) as regenerative, off-the-shelf therapeutic agents.

TL;DR: In this article , the advantages and disadvantages of MSPNDs, salipros, and copolymer nanodiscs are compared to highlight potential opportunities for using each platform for MP purification and characterization.

TL;DR: In this article , the authors present a systematic interpretation of biomechanisms for HTPSs, and correspondingly, address biomimetic strategies and technologies contributing to ATSSs as an integral system.

TL;DR: In this article , the prostate cancer (PC) is one of the most common tumors and a leading cause of mortality among men, resulting in ~375 000 deaths annually worldwide, and various analytical methods have been designed for quantitative and rapid detection of PC biomarkers.

TL;DR: In this article , the authors discuss the use of orally delivered single-domain antibodies (sdabs) for protecting humans and animals against GI infections caused by pathogenic bacteria, viruses, and parasites.

TL;DR: In this paper , De Proost and Segers provide further reflections on how technologies induce moral change and discuss moral changes at the societal level as distinguished from changes in bioethical principles or ethical concepts, impacts on theories of justice, and whether the transformations are negative or positive.

TL;DR: In this paper , the compatibility of cell-stretching devices (CSDs) with live-cell imaging as well as their limitations and on the research advancements that could arise from live cell imaging performed during cell stretching are discussed.

TL;DR: In this paper , the authors used an in silico-to-in vivo workflow to enable the high-level bioproduction of the unnatural small molecule 1,4-butanediol in the bacterium Escherichia coli.

TL;DR: In this paper , a review examines the lessons learned when studying microbial physiology and metabolism under conditions that simulate large-scale bioreactors and methods to minimize cellular waste through reduction of maintenance energy, optimizing the stress response and minimizing culture heterogeneity.

TL;DR: In this paper , the authors outline the utility of four iPSC-derived immune-cell-based therapies and highlight the latest progress and future trends in the genome-editing strategies designed to improve efficacy, safety, and universality.

TL;DR: Morsut et al. as discussed by the authors reported a synthetic receptor system, based on the natural Notch receptor, with customizable input and output functions, and their work on advanced receptor design expands the reach of synthetic receptor systems.