L
Li Zhang
Researcher at University of Michigan
Publications - 242
Citations - 7643
Li Zhang is an academic researcher from University of Michigan. The author has contributed to research in topics: Video decoder & Biology. The author has an hindex of 34, co-authored 213 publications receiving 5976 citations. Previous affiliations of Li Zhang include Qualcomm & United States Department of Veterans Affairs.
Papers
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Journal ArticleDOI
Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion
Cristovão M. Sousa,Douglas E. Biancur,Xiaoxu Wang,Christopher J. Halbrook,Mara H. Sherman,Li Zhang,Daniel M. Kremer,Rosa F. Hwang,Agnieszka K. Witkiewicz,Haoqiang Ying,John M. Asara,Ronald M. Evans,Lewis C. Cantley,Costas A. Lyssiotis,Alec C. Kimmelman,Alec C. Kimmelman +15 more
TL;DR: The results demonstrate a novel metabolic interaction between PSCs and cancer cells, in which PSC-derived alanine acts as an alternative carbon source and highlights a previously unappreciated metabolic network within pancreatic tumours in which diverse fuel sources are used to promote growth in an austere tumour microenvironment.
Journal ArticleDOI
Cysteine depletion induces pancreatic tumor ferroptosis in mice.
Michael A. Badgley,Daniel M. Kremer,H. Carlo Maurer,H. Carlo Maurer,Kathleen E. DelGiorno,Ho-Joon Lee,Vinee Purohit,Irina Sagalovskiy,Alice Ma,Jonathan Kapilian,Christina E. M. Firl,Amanda R. Decker,Steve A. Sastra,Carmine F. Palermo,Leonardo R. Andrade,Peter Sajjakulnukit,Li Zhang,Zachary P. Tolstyka,Tal Hirschhorn,Candice Lamb,Tong Liu,Wei Gu,E. Scott Seeley,Everett Stone,George Georgiou,Uri Manor,Alina Iuga,Geoffrey M. Wahl,Brent R. Stockwell,Costas A. Lyssiotis,Kenneth P. Olive +30 more
TL;DR: This work shows that the import of oxidized cysteine (cystine) via system xC– is a critical dependency of pancreatic ductal adenocarcinoma (PDAC), which is a leading cause of cancer mortality.
Journal ArticleDOI
Phosphoinositide 3-kinase(p110α) plays a critical role for the induction of physiological, but not pathological, cardiac hypertrophy
Julie R. McMullen,Tetsuo Shioi,Li Zhang,Oleg Tarnavski,Megan C. Sherwood,Peter M. Kang,Seigo Izumo +6 more
TL;DR: PI3K(p110α) appears to play a critical role for the induction of physiological cardiac growth but not pathological growth, and appears essential for maintaining contractile function in response to pathological stimuli.
Journal ArticleDOI
Inhibition of mTOR Signaling With Rapamycin Regresses Established Cardiac Hypertrophy Induced by Pressure Overload
Julie R. McMullen,Megan C. Sherwood,Oleg Tarnavski,Li Zhang,Adam L. Dorfman,Tetsuo Shioi,Seigo Izumo +6 more
TL;DR: Rapamycin may be a therapeutic tool to regress established cardiac hypertrophy and improve cardiac function.
Journal ArticleDOI
The Insulin-like Growth Factor 1 Receptor Induces Physiological Heart Growth via the Phosphoinositide 3-Kinase(p110α) Pathway
Julie R. McMullen,Tetsuo Shioi,Weei Yuarn Huang,Li Zhang,Oleg Tarnavski,Egbert Bisping,Martina Schinke,Sek Won Kong,Megan C. Sherwood,Jeffrey Brown,Lauren Riggi,Peter M. Kang,Seigo Izumo +12 more
TL;DR: This study suggests that targeting the cardiac IGF1R-PI3K(p110α) pathway could be a potential therapeutic strategy for the treatment of heart failure.