S
Sang Yup Lee
Researcher at KAIST
Publications - 1053
Citations - 62209
Sang Yup Lee is an academic researcher from KAIST. The author has contributed to research in topics: Metabolic engineering & Escherichia coli. The author has an hindex of 117, co-authored 1005 publications receiving 53257 citations. Previous affiliations of Sang Yup Lee include Technical University of Denmark & Samsung.
Papers
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Journal ArticleDOI
antiSMASH 5.0: updates to the secondary metabolite genome mining pipeline
Kai Blin,Simon Shaw,Katharina Steinke,Rasmus Villebro,Nadine Ziemert,Sang Yup Lee,Sang Yup Lee,Marnix H. Medema,Tilmann Weber +8 more
TL;DR: AntiSMASH 5 adds detection rules for clusters encoding the biosynthesis of acyl-amino acids, β-lactones, fungal RiPPs, RaS-Ri PPs, polybrominated diphenyl ethers, C-nucleosides, PPY-like ketones and lipolanthines and provides more detailed predictions for type II polyketide synthase-encoding gene clusters.
Journal ArticleDOI
antiSMASH 3.0—a comprehensive resource for the genome mining of biosynthetic gene clusters
Tilmann Weber,Kai Blin,Srikanth Duddela,Daniel Krug,Hyun Uk Kim,Robert E. Bruccoleri,Sang Yup Lee,Sang Yup Lee,Michael A. Fischbach,Rolf Müller,Wolfgang Wohlleben,Rainer Breitling,Eriko Takano,Marnix H. Medema,Marnix H. Medema +14 more
TL;DR: AntiSMASH as mentioned in this paper is a web server and stand-alone tool for the automatic genomic identification and analysis of biosynthetic gene clusters, available at http://antismash.org.
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Metabolic engineering of Escherichia coli for direct production of 1,4-butanediol
Harry Yim,Robert Haselbeck,Wei Niu,Catherine J. Pujol-Baxley,Anthony P. Burgard,Jeff Boldt,Julia Khandurina,John D. Trawick,Robin E. Osterhout,Rosary Stephen,Jazell Estadilla,Sy Teisan,H. Brett Schreyer,Stefan Andrae,Tae Hoon Yang,Sang Yup Lee,Mark J. Burk,Stephen J. Van Dien +17 more
TL;DR: This work engineered the E. coli host to enhance anaerobic operation of the oxidative tricarboxylic acid cycle, thereby generating reducing power to drive the BDO pathway, leading to a strain of Escherichia coli capable of producing 18 g l(-1) of this highly reduced, non-natural chemical.
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antiSMASH 4.0-improvements in chemistry prediction and gene cluster boundary identification.
Kai Blin,Thomas Wolf,Marc G. Chevrette,Xiaowen Lu,Christopher J. Schwalen,Satria A. Kautsar,Hernando G. Suarez Duran,Emmanuel L. C. de los Santos,Hyun Uk Kim,Mariana Nave,Jeroen S. Dickschat,Douglas A. Mitchell,Ekaterina Shelest,Rainer Breitling,Eriko Takano,Sang Yup Lee,Tilmann Weber,Marnix H. Medema +17 more
TL;DR: The thoroughly updated antiSMASH version 4 is presented, which adds several novel features, including prediction of gene cluster boundaries using the ClusterFinder method or the newly integrated CASSIS algorithm, improved substrate specificity prediction for non-ribosomal peptide synthetase adenylation domains based on the new SANDPUMA algorithm, and several usability features have been updated and improved.
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Fermentative butanol production by clostridia
TL;DR: This article reviews biotechnological production of butanol by clostridia and some relevant fermentation and downstream processes and the strategies for strain improvement by metabolic engineering and further requirements to make fermentative butanol production a successful industrial process.