Journal ArticleDOI
1-alpha-acetylmethadol(LAAM) pharmacokinetics and metabolism: current status.
A. L. Misra,S. J. Mulé +1 more
Reads0
Chats0
TLDR
The current status of acetylmethadol Pharmacokinetics and Metabolism is unknown because of the high level of uncertainty in the experimental data.Abstract:
(1975). 1-α -Acetylmethadol (LAAM) Pharmacokinetics and Metabolism: Current Status. The American Journal of Drug and Alcohol Abuse: Vol. 2, No. 3-4, pp. 301-305.read more
Citations
More filters
Book ChapterDOI
Long-Term Pharmacotherapy for Opiate (Primarily Heroin) Addiction: Opioid Agonists
TL;DR: Significant findings based on carefully conducted basic and applied clinical research studies showed the efficacy of a pharma-cotherapy for addiction specifically using methadone maintenance treatment.
Book ChapterDOI
Pharmacology of Opiates
Lisa Borg,Mary Jeanne Kreek +1 more
TL;DR: There are three major opioid receptors in the central nervous system: mu, kappa, and delta, the genes for which have been cloned, and there are also possible subtypes within each class, although separate genes have not yet beenCloned for any subtypes.
Journal ArticleDOI
PHARMACOLOGY OF ℓ-α-ACETYLMETHADOL (LAAM) IN SUBHUMAN PRIMATES*
S.J. Mulé,A.L. Misra +1 more
TL;DR: The physiological disposition, pharmacokinetics and metabolism of LAAM in acutely and chronically-treated monkeys are described and attempts to correlate pharmacologic activity, duration of action, tolerance development and possible systemic toxicity in the monkey are attempted.
Journal ArticleDOI
Severe toxicity and lethality in some monkeys following chronic administration of levo-alpha-acetylmethadol (LAAM).
A.L. Misra,S.J. Mulé +1 more
TL;DR: Differential rates of formation and elimination of active metabolites of LAAM may play a significant role in this potentially lethal toxicity and may have important clinical implications for LAAM maintenance treatment programs.
Journal ArticleDOI
Pharmacotherapy of narcotic dependence.
TL;DR: The pharmacological actions of pure and partial antagonists are presented noting the differential properties that have practical application in helping to control opiate dependence and even prevent the development of a potential narcotic addict.
References
More filters
Journal Article
Actions and addiction liabilities of alpha-acetyl-methadols in man.
H. F. Fraser,Harris Isbell +1 more
TL;DR: Single subcutaneous or intravenous doses of d -alpha-acetylmethadol in former morphine addicts promptly induced a train of morphine-like effects which disappeared in less than 24 hours.
Journal ArticleDOI
Methadyl Acetate vs Methadone: A Double-Blind Study in Heroin Users
Jerome H. Jaffe,Edward C. Senay,Charles R. Schuster,Pierre R. Renault,Beth B. Smith,Salvatore DiMenza +5 more
TL;DR: The results suggest that the advantages of methadyl acetate, namely reduction in the frequency of clinic visits and the possibility of more effective control over administration and illegal redistribution, are not outweighed by any problems detectable under the conditions of the present study.
Journal ArticleDOI
Comparison of acetylmethadol and methadone in the treatment of long-term heroin users. A pilot study.
TL;DR: Over a five-week period of observation there were no differences in social adjustment between those patients whose conditions were maintained with a daily methadone regimen and those given d1-α-acetylmethadol three times a week.
Journal ArticleDOI
l-Acetylmethadol (LAM) treatment of opiate dependence: plasma and urine levels of two pharmacologically active metabolites.
TL;DR: Variations in the rates of formation and elimination of NAM and NNAM may partially explain the variability in response seen in LAM maintenance therapy.
Related Papers (5)
Naltrexone Pharmacology, Pharmacokinetics, and Metabolism: Current Status
K. Verebey,S.J. Mulé +1 more