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Book ChapterDOI

12 – Recent Advances

TLDR
This chapter provides an overview on the growing points in biochemical disorders of the skeleton as it clearly has other important functions in basement membranes, in platelet aggregation and in tissues, such as muscle, during their development.
Abstract
Publisher Summary This chapter provides an overview on the growing points in biochemical disorders of the skeleton. One of the most striking aspects of collagen is its almost universal distribution. No longer should it be regarded merely as a protein of fibrous tissues, as it clearly has other important functions in basement membranes, in platelet aggregation and in tissues, such as muscle, during their development. Calcitonin may be measured within the physiological range in plasma, though the recorded normal values differ according to the method used. In 1978, Hillyard, Stevenson, and Maclntyre confirmed that levels of immunoreactive calcitonin are low in women compared with men, and are increased by oral oestrogen — progestagen pills, and by pregnancy.

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Journal ArticleDOI

Osteomalacic dialysis osteodystrophy: Evidence for a water-borne aetiological agent, probably aluminium.

TL;DR: The evidence that aluminium absorption from dialysate causes osteomalacia and encephalopathy is strong enough to justify the expense of treating water by deionisation, reverse osmosis, or both in centres where tap-water aluminium is high.
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Vitamin-D-dependent rickets type II. Resistance of target organs to 1,25-dihydroxyvitamin D.

TL;DR: The results suggest that the disorder results from impaired end-organ response to 1,25-dihydroxyvitamin D, and it is proposed that the entity be called vitamin-D-dependent rickets Type II.
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Bone response to termination of œstrogen treatment

TL;DR: It is indicated that long-term prevention of bone loss by oestrogens has important medical, social, economic implications.
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Preservation of Function in Experimental Renal Disease by Dietary Restriction of Phosphate

TL;DR: The results suggest that the calcification produced by the altered phosphorus metabolism present in the uremic state incites an inflammatory and fibrotic reaction leading to destruction of the remnant kidney.
Journal ArticleDOI

Attainment and Maintenance of Normal Stature with Alkali Therapy in Infants and Children with Classic Renal Tubular Acidosis

TL;DR: Growth was evaluated in a group of 10 infants and children with familial or idiopathic classic renal tubular acidosis in whom alkali therapy was initiated at ages ranging from 8 days to 9.5 yr and administered at dosage schedules documented to sustain correction of acidosis.