Journal ArticleDOI
18F‐Fluorodeoxyglucose Positron Emission Tomography–Computed Tomography Imaging in the Management of Merkel Cell Carcinoma: A Single‐Institution Retrospective Study
Sherrif F. Ibrahim,Iris Ahronowitz,Timothy H. McCalmont,Miguel Hernandez Pampaloni,Julie L. Ryan,Siegrid S. Yu +5 more
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TLDR
F fluorodeoxyglucose‐positron emission tomography and computed tomography is a valuable tool for initial staging and to assess response to therapy of patients diagnosed with MCC and larger prospective studies would be required to establish the optimal timing for this imaging modality.Abstract:
BackgroundMerkel cell carcinoma (MCC) is among the deadliest of cutaneous malignancies. A lack of consensus evaluation and treatment guidelines has hindered management of this disease. The utility of simultaneous positron emission tomography and computed tomography (PET/CT) has been demonstrated forread more
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Journal ArticleDOI
Merkel cell carcinoma: An update and review: Current and future therapy.
TL;DR: Because of the complexity, aggressive nature, and individuality of each case, MCC is best treated by a multidisciplinary team.
Journal ArticleDOI
Diagnostic performance of fluorine-18-fluorodeoxyglucose positron emission tomography in patients with Merkel cell carcinoma: a systematic review and meta-analysis.
TL;DR: In patients with MCC, 18F-FDG PET or PET/CT demonstrated high sensitivity and specificity, being accurate methods in this setting, Nevertheless, the literature focusing on the use of PET and PET/ CT in MCC still remains limited.
Journal ArticleDOI
The impact of (18)F-FDG-PET/CT on Merkel cell carcinoma management: a retrospective study of 66 scans from a single institution.
Adeline George,Sylvie Girault,Aude Testard,Remy Delva,Patrick Soulié,Olivier-F. Couturier,Olivier Morel +6 more
TL;DR: A retrospective study confirms the important impact of 18F-FDG-PET/CT on the management of MCC patients and identifies four additional histologically confirmed cancers.
Journal ArticleDOI
18 F-FDG and 68 Ga-somatostatin analogs PET/CT in patients with Merkel cell carcinoma: a comparison study
Silvia Taralli,Martina Sollini,Michele Milella,Germano Perotti,Angelina Filice,Massimo Menga,Annibale Versari,Vittoria Rufini +7 more
TL;DR: Preliminary data suggest that 18F-FDG and 68Ga-somatostatin analog PET/CT provide good and equivalent diagnostic performance in MCC patients, adding interesting insights into the complex MCC biology.
Journal ArticleDOI
A Case Series and Literature Review of Merkel Cell Carcinoma Metastasizing to Pancreas
Yezaz A. Ghouri,Yezaz A. Ghouri,Somashekar G. Krishna,Uma Kundu,Manoop S. Butani,Jeffrey H. Lee,William A. Ross +6 more
TL;DR: EUS-FNA is an effective tool that can be utilized in diagnosing pancreatic masses and differentiating metastatic pancreatic tumors from primary pancreatic tumor is useful as systemic therapy is an option in pancreatic adenocarcinoma, but is ineffective in metastatic Merkel cell carcinoma.
References
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Journal ArticleDOI
Clonal integration of a polyomavirus in human Merkel cell carcinoma.
TL;DR: In six of eight MCV-positive MCCs, viral DNA was integrated within the tumor genome in a clonal pattern, suggesting that MCV infection and integration preceded clonal expansion of the tumor cells, and MCV may be a contributing factor in the pathogenesis of MCC.
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Merkel Cell Carcinoma: Prognosis and Treatment of Patients From a Single Institution
Peter J. Allen,Wilbur B. Bowne,David P. Jaques,Murray F. Brennan,Klaus J. Busam,Daniel G. Coit +5 more
TL;DR: The data demonstrate that the natural history of MCC is variable and dependent on the stage of disease at presentation, and pathologic nodal staging identifies a group of patients with excellent long-term survival.
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Merkel cell carcinoma
TL;DR: Opinion statementMerkel cell carcinoma is a rare cutaneous neoplasm most commonly affecting the head and neck of elderly white patients, and no single standard of care exists for the treatment of this aggressive tumor.
Journal ArticleDOI
Merkel cell carcinoma: changing incidence trends.
TL;DR: The objective of this study was to define the incidence trends of Merkel cell carcinoma (MCC), a rare and aggressive cutaneous malignancy.