3 3 Method and Apparatus for Generating 3D Fluorescent Label Image of Label-Free using 3D Refractive Index Tomography and Deep Learning

TLDR: In this paper, a method and apparatus for generating a 3D molecular image based on a label-free method using a 3-D refractive index image and deep learning is presented.

Abstract: Disclosed are a method and apparatus for generating a three-dimensional (3-D) molecular image based on a label-free method using a 3-D refractive index image and deep learning. The apparatus for generating a 3-D molecular image based on a label-free method using a 3-D refractive index image and deep learning may include a 3-D refractive index cell image measurement unit configured to measure a 3-D refractive index image of a cell to be monitored and a 3-D refractive index and fluorescence molecule staining image conversion unit configured to input a measured value of the 3-D refractive index image to a deep learning algorithm and to output a 3-D fluorescence molecule staining cell image of the cell.