Quantitative phase imaging techniques for the study of cell pathophysiology: from principles to applications.
KyeoReh Lee,Kyoohyun Kim,JaeHwang Jung,Ji Han Heo,Sangyeon Cho,SangYun Lee,Gyuyoung Chang,YoungJu Jo,HyunJoo Park,YongKeun Park +9 more
TLDR
The principles of QPI are presented and some of the recent applications ranging from cell homeostasis to infectious diseases and cancer are highlighted, to provide important insight on how the QPI techniques potentially improve the study of cell pathophysiology.Abstract:
A cellular-level study of the pathophysiology is crucial for understanding the mechanisms behind human diseases. Recent advances in quantitative phase imaging (QPI) techniques show promises for the cellular-level understanding of the pathophysiology of diseases. To provide important insight on how the QPI techniques potentially improve the study of cell pathophysiology, here we present the principles of QPI and highlight some of the recent applications of QPI ranging from cell homeostasis to infectious diseases and cancer.read more
Citations
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Journal Article
Fourier-transform method of fringe-pattern analysis for computer-based topography and interferometry
TL;DR: In this article, a fast Fourier transform method of topography and interferometry is proposed to discriminate between elevation and depression of the object or wave-front form, which has not been possible by the fringe-contour generation techniques.
Spatial light interference microscopy (SLIM)
TL;DR: Spatial light interference microscopy reveals the intrinsic contrast of cell structures and renders quantitative optical path-length maps across the sample, which may prove instrumental in impacting the light microscopy field at a large scale.
Journal ArticleDOI
Diffraction phase microscopy: principles and applications in materials and life sciences
Basanta Bhaduri,Chris Edwards,Hoa V. Pham,Renjie Zhou,Tan H. Nguyen,Lynford L. Goddard,Gabriel Popescu +6 more
TL;DR: In this article, the authors present a diffraction phase microscopy (DPM) system, which is a common-path quantitative phase imaging (QPI) method that significantly alleviates the noise problem.
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High-resolution three-dimensional imaging of red blood cells parasitized by Plasmodium falciparum and in situ hemozoin crystals using optical diffraction tomography
TL;DR: In this paper, high-resolution optical tomographic images of human red blood cells (RBC) parasitized by malaria-inducing Plasmodium falciparum (Pf)-RBCs are reconstructed by recourse to a diffraction algorithm from multiple two-dimensional holograms with various angles of illumination.
Journal ArticleDOI
High-resolution transport-of-intensity quantitative phase microscopy with annular illumination
TL;DR: In this article, a matched annular illumination was proposed to boost the phase contrast for low spatial frequencies, and significantly improved the practical imaging resolution to near the incoherent diffraction limit, achieving a transverse resolution up to 208 nm.
References
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Book
Principles of Computerized Tomographic Imaging
TL;DR: Properties of Computerized Tomographic Imaging provides a tutorial overview of topics in tomographic imaging covering mathematical principles and theory and how to apply the theory to problems in medical imaging and other fields.
Journal Article
Fourier-transform method of fringe-pattern analysis for computer-based topography and interferometry
TL;DR: In this article, a fast Fourier transform method of topography and interferometry is proposed to discriminate between elevation and depression of the object or wave-front form, which has not been possible by the fringe-contour generation techniques.
Journal ArticleDOI
Fourier-transform method of fringe-pattern analysis for computer-based topography and interferometry
TL;DR: In this paper, a fast Fourier transform method of topography and interferometry is proposed to discriminate between elevation and depression of the object or wave-front form, which has not been possible by the fringe-contour generation techniques.
Journal ArticleDOI
Focusing coherent light through opaque strongly scattering media
Ivo M. Vellekoop,Allard Mosk +1 more
TL;DR: Focusing of coherent light through opaque scattering materials by control of the incident wavefront with a brightness up to a factor of 1000 higher than the brightness of the normal diffuse transmission is reported.
Journal ArticleDOI
Controlling waves in space and time for imaging and focusing in complex media
TL;DR: In this article, the authors used strongly scattering materials to focus, shape and compress waves by controlling the many degrees of freedom in the incident waves in complex media such as white paint and biological tissue.