Patent
4-amino- quinazoline and quinoline derivatives having an inhibitory effect on signal transduction mediated by tyrosine kinases
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TLDR
In this paper, the present invention relates to bicyclic heterocycles of general formula (I), wherein Ra to Rd, A to G and X are defined as in claim 1, the tautomers, the stereoisomers and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases which have valuable pharmacological properties, particularly an inhibiting effect on signal transduction mediated by tyrosine kinases.Abstract:
The present invention relates to bicyclic heterocycles of general formula (I), wherein Ra to Rd, A to G and X are defined as in claim 1, the tautomers, the stereoisomers and the salts thereof, particularly the physiologically acceptable salts thereof particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases which have valuable pharmacological properties, particularly an inhibiting effect on signal transduction mediated by tyrosine kinases, their use for treating diseases, particularly tumoral diseases, diseases of the lungs and respiratory tract, and the preparation thereof.read more
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Quinazoline derivatives for the treatment of tumours
TL;DR: In this paper, the authors describe quinazoline derivatives of Formula (I) for use as an anti-invasive agent in the containment and/or treatment of solid tumour disease.
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Substituted 3-cyanoquinolines
Allan Wissner,Hwei-Ru Tsou,Dan M. Berger,Middleton Brawner Floyd,Philip R. Hamann,Nan Zhang,Frost Philip +6 more
TL;DR: In this paper, the authors provide compounds of formula I having the structure wherein G 1, G 2, R 1, R 4, Z, n, and X are defined in the specification or a pharmaceutically acceptable salt thereof which are useful as antineoplastic agents and in the treatment of polycystic kidney disease.
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Quinazoline derivatives as antitumor agents
TL;DR: In this article, quinazoline derivatives of Formula (I) have been used in the manufacture of a medicament for use in the prevention or treatment of tumours which are sensitive to inhibition of erbB receptor tyrosine kinases.
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Bicyclic heterocycles, medicaments containing these compounds, their use and methods for the production thereof
TL;DR: In this paper, the use of the inventive bicyclic heterocycles for treating illnesses, especially tumor diseases, diseases of the lung and of the respiratory tract, and relates to the production of inventive compounds.
Patent
Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for preparing them
TL;DR: In this paper, the present invention relates to bicyclic heterocyclic compounds of general formula (I), wherein R a to R d, A to D and X are defined as in claims 1 to 8, the tautomers, stereoisomers and salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases which have valuable pharmacological properties.
References
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Quinazoline derivatives as VEGF inhibitors
TL;DR: In this paper, the quinazoline derivatives of formula (I) were defined, where m is an integer from 1 to 3; R 1 represents halogeno or C?1-3?alkyl; X?1? represents -O-; R 2 is selected from one of the following three groups: 1) piperidin-4-yl, C?2-5?alkynylR?3? (wherein R 3 is as defined hereinbefore); and salts thereof; processes for their preparation, pharmaceutical compositions containing a compound of
Patent
Substituted 3-cyano quinolines
Allan Wissner,Bernard Dean Johnson,Marvin F Reich,Middleton Brawner Floyd,Douglas B. Kitchen,Hwei-Ru Tsou +5 more
TL;DR: In this paper, the authors define compounds having formula (1) wherein: X is cycloalkyl which may be optionally substituted; or is a pyridinyl, pyrimidinyl or phenyl ring; n is 0-1; Y is -NH-, -O-, -S-, or -NR-; R is alkyl of 1-6 carbon atoms; R1, R2, R3, R4 and R4 are each, independently, hydrogen, halogen, alkyyl, alkenyl, alkynyl, and
Patent
4-anilinoquinazoline derivatives
TL;DR: In this article, the quinazoline derivatives of formula (I) (wherein: R1 represents hydrogen or methoxy; R2 represents methoxy, ethoxy, 2-methoxyethoxy, 3-methylpiperazin-1-yl)propoxy or 4-(4-methylpiperizin- 1yl)butoxy; the phenyl group bearing (R3)2 is selected from: 2-fluoro-5-hydroxyphenyl, 4-bromo-2-fluorophenyl,
Patent
Quinazoline derivatives and pharmaceutical compositions containing them
Thomas Andrew Peter,Johnstone Craig,Clayton Edward,Stokes Elaine Sophie Elizabeth,Jean-Jacques Marcel Lohmann,Hennequin Laurent Francois And +5 more
TL;DR: In this paper, the authors defined quinazoline derivatives of formula (I) where m is an integer from 1 to 2, where m represents hydrogen, hydroxy, halogeno, methoxy, amino or nitro.
Patent
Substituted quinazoline derivatives and their use as tyrosine kinase inhibitors
TL;DR: In this paper, the authors provided compounds of formula (1) wherein X is C3-7 cycloalkyl, pyridinyl, pyrimidinyl or phenyl ring optionally substituted as described in claim 1, R1, R3 and R4 are chosen from the groups listed in claim 2, with certain compounds being disclaimed.