Journal ArticleDOI
99Tcm chemical state in 99Tcm labeled radio-pharmaceuticals—I. Preparation and biological behavior of 99Tcm-penicillamine complex with a low hydrolyzed 99Tcm state
Akira Yokoyama,Hideo Saji,Kazuko Horiuchi,Hisashi Tanaka,Teruo Odori,Rikushi Morita,Toru Mori,Kanji Torizuka +7 more
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This article is published in International Journal of Nuclear Medicine and Biology.The article was published on 1978-03-01. It has received 11 citations till now. The article focuses on the topics: Chemical state.read more
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Radiolabeling with technetium-99m to study high-capacity and low-capacity biochemical systems.
TL;DR: The use of technetium chelates in high-capacity systems is discussed, and attention is given to factors that affect the preparation of high specific activity, high affinity99mTc-labeled biochemicals.
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The design of a pentavalent 99mTc-dimercaptosuccinate complex as a tumor imaging agent.
Akira Yokoyama,Naotaka Hata,Kazuko Horiuchi,Hidesuke Masuda,Hideo Saji,Hitoya Ohta,Kazutaka Yamamoto,Keigo Endo,Kanji Torizuka +8 more
TL;DR: Its distinctive characteristic, different from the kidney imaging agent (99mTc-DMSA), is demonstrated and the biological implication of hydrolytic polynucleation of pentavalent technetium, through an anionic specie Tc(V)O3-(4), in the tumor cell is discussed.
Journal ArticleDOI
In vivo chemistry of 99mTc-chelates.
TL;DR: 99mTc-chelates considered optimal for hepatobiliary imaging have a high liver extraction efficiency, are rapidly transported through the liver and have a comparatively slow renal clearance rate.
Journal ArticleDOI
Oxidation state of technetium in bone scanning agents as determined at carrier concentration by amperometric titration.
Charles D. Russell,Anna G. Cash +1 more
TL;DR: The amperometric titration method appears generally useful for identifying the oxidation state of technetium in radiopharmaceuticals prepared by reduction with Sn(II) or other fast-acting reductants.
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Determination of pertechnetate in radiopharmaceuticals by high-pressure liquid thin-layer and paper chromatography
TL;DR: In this article, a method for determining pertevhnetate ion by high pressure liquid chromatography (HPLC) was developed. But the results are often sensitive to variations in procedure, particularly with relatively unstable agents such as pyrophosphate.
References
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Journal ArticleDOI
Zur chemie des technetium in wäßriger lösung—I: Über den zustand des vierwertigen technetium in wäßriger lösung
B. Gorski,H. Koch +1 more
TL;DR: In this paper, the Zustand des vierwertigen Technetium in wasriger Losung wurde mit Hilfe der Elektrophoresemethode untersucht.
Journal Article
Preparation of a Chemically Characterized 99mTc-Penicillamine Complex
TL;DR: Highly reproducible in vivo behavior in mice and rats was obtained with this chemically controlled Complex I, based on the thesis that Complex I formation competes with 99mTcO+2 hydrolysis, which leads to other 99m Tc complexes.
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Electron transfer reactions and the nature of the solvent effect on tris-toluene-3,4-dithiolates of rhenium, tungsten, molybdenum and technetium
TL;DR: The electron transfer reactions of tris-toluene-3,4-dithiolates of Re, W, Mo and Tc with organic bases have been investigated by means of spectrophotometry and voltammetry as mentioned in this paper.
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Recent Advances in Nuclear Medicine
TL;DR: This volume is intended as both a historical document and a presentation of the current status of instrumentation in radiopharmaceuticals and positron emission tomography and of the use of neutrons and heavy ions for radiography and tumor therapy.
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Gel Chromatographic Behavior of Aqueous Ferric Nitrate
R. A. Henry,L. B. Rogers +1 more
TL;DR: In this article, the authors investigated polydextran gels having various exclusion limits and found that excluded iron moving in the void volume and admitted iron moving near the total liquid volume of the gel.