W
William C. Eckelman
Researcher at National Institutes of Health
Publications - 166
Citations - 7001
William C. Eckelman is an academic researcher from National Institutes of Health. The author has contributed to research in topics: In vivo & Receptor. The author has an hindex of 43, co-authored 166 publications receiving 6796 citations. Previous affiliations of William C. Eckelman include University of California, San Diego & MSC Industrial Direct Company, Inc..
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Journal ArticleDOI
Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: Evidence from a novel positron emission tomography method
Alan Breier,T.-P. Su,Richard C. Saunders,Richard E. Carson,Bhaskar Kolachana,A. De Bartolomeis,Daniel R. Weinberger,Neil I. Weisenfeld,Anil K. Malhotra,William C. Eckelman,David Pickar +10 more
TL;DR: In the clinical study, patients with schizophrenia compared with healthy volunteers had significantly greater amphetamine-related reductions in [11C]raclopride specific binding, providing direct evidence for the hypothesis of elevated Amphetamine-induced synaptic dopamine concentrations in schizophrenia.
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Long-Term Clinical Improvement in MPTP-Lesioned Primates after Gene Therapy with AAV-hAADC
Krystof S. Bankiewicz,John Forsayeth,Jamie L. Eberling,Rosario Sanchez-Pernaute,Philip Pivirotto,John Bringas,Peter Herscovitch,Richard E. Carson,William C. Eckelman,Bryan W. Reutter,Janet Cunningham +10 more
TL;DR: Introduction of this therapy into the clinic holds promise for Parkinson patients experiencing the motor complications that result from escalating l-Dopa requirements against a background of disease progression.
Journal ArticleDOI
The Progress and Promise of Molecular Imaging Probes in Oncologic Drug Development
Gary J. Kelloff,Kenneth A. Krohn,Steven M. Larson,Ralph Weissleder,David A. Mankoff,John M. Hoffman,Jeanne M. Link,Kathryn Z. Guyton,William C. Eckelman,Howard I. Scher,Joyce O'Shaughnessy,Bruce D. Cheson,Caroline C. Sigman,James L. Tatum,George Q. Mills,Daniel C. Sullivan,Janet Woodcock +16 more
TL;DR: The scientific basis of oncology imaging probes is outlined and examples of probes that could facilitate progress are presented, with a focus on recent Food and Drug Administration guidance to facilitate early clinical development of promising probes.
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Quantification of Amphetamine-Induced Changes in [11C]Raclopride Binding with Continuous Infusion
Richard E. Carson,Alan Breier,Andrea de Bartolomeis,Richard C. Saunders,T.-P. Su,Bernard Schmall,Margaret G. Der,David Pickar,William C. Eckelman +8 more
TL;DR: In this article, the authors measured the change in [11C]raclopride-specific binding in rhesus monkeys after i.v. administration of 0.4 mg/kg amphetamine by using both the bolus and B/I paradigms.
Journal ArticleDOI
PET imaging of 5-HT1A receptor binding in patients with temporal lobe epilepsy
Maria T. Toczek,Richard E. Carson,L. Lang,Y. Ma,Marianna Spanaki,Margaret G. Der,S. Fazilat,Leonid Kopylev,Peter Herscovitch,William C. Eckelman,William H. Theodore +10 more
TL;DR: The hypothesis of reduced serotonin receptor binding in temporal lobe epileptic foci is supported by the findings of PET imaging and MRI.