A comprehensive overview of radioguided surgery using gamma detection probe technology
Stephen P. Povoski,Ryan L. Neff,Cathy Mojzisik,David M. O'Malley,George H. Hinkle,Nathan Hall,Douglas A Murrey,Michael V. Knopp,Edward W. Martin +8 more
Reads0
Chats0
TLDR
In the current review, this work has attempted to comprehensively evaluate the history, technical aspects, and clinical applications of radioguided surgery using gamma detection probe technology.Abstract:
The concept of radioguided surgery, which was first developed some 60 years ago, involves the use of a radiation detection probe system for the intraoperative detection of radionuclides. The use of gamma detection probe technology in radioguided surgery has tremendously expanded and has evolved into what is now considered an established discipline within the practice of surgery, revolutionizing the surgical management of many malignancies, including breast cancer, melanoma, and colorectal cancer, as well as the surgical management of parathyroid disease. The impact of radioguided surgery on the surgical management of cancer patients includes providing vital and real-time information to the surgeon regarding the location and extent of disease, as well as regarding the assessment of surgical resection margins. Additionally, it has allowed the surgeon to minimize the surgical invasiveness of many diagnostic and therapeutic procedures, while still maintaining maximum benefit to the cancer patient. In the current review, we have attempted to comprehensively evaluate the history, technical aspects, and clinical applications of radioguided surgery using gamma detection probe technology.read more
Citations
More filters
Journal ArticleDOI
Photoacoustic clinical imaging
Idan Steinberg,David M. Huland,Ophir Vermesh,Hadas Frostig,Willemieke S. Tummers,Sanjiv S. Gambhir +5 more
TL;DR: The various clinical and pre-clinical literature is surveyed and the potential applications and hurdles that still need to be overcome are discussed.
Journal ArticleDOI
Multiplexed imaging for diagnosis and therapy
TL;DR: Criteria for conducting multiplexed imaging is evaluated, and its opportunities for improving patient diagnosis and the monitoring of therapy are discussed, and targeted palettes of molecular imaging probes facilitate the detection of heterogeneity in oncogene-driven alterations and their response to treatment.
Journal ArticleDOI
Nuclear probes and intraoperative gamma cameras.
Sherman Heller,Pat Zanzonico +1 more
TL;DR: Intraoperative sentinel lymph node as well as tumor detection may be improved under some circumstances by the use of beta (negatron or positron), rather than gamma detection, because the very short range of such particulate radiations eliminates the contribution of confounding counts from activity other than in the immediate vicinity of the detector.
Journal ArticleDOI
Intraoperative gamma cameras for radioguided surgery: technical characteristics, performance parameters, and clinical applications.
TL;DR: The characteristics, performance, and clinical use of SGCs, which are hand-held and small enough to be easily managed by surgeons during their procedures, are discussed.
References
More filters
Journal ArticleDOI
Continuous cultures of fused cells secreting antibody of predefined specificity
G Köhler,C. Milstein +1 more
TL;DR: The derivation of a number of tissue culture cell lines which secrete anti-sheep red blood cell (SRBC) antibodies is described here, made by fusion of a mouse myeloma and mouse spleen cells from an immunised donor.
Recommendations of the international commission on radiological protection
R.M. Sievert,G. Failla +1 more
TL;DR: Recommendations are presented which represent concepts and practices evolved from recent discussions at formal and informal meetings of the Commission and its Committees.
Journal ArticleDOI
Technical details of intraoperative lymphatic mapping for early stage melanoma.
Donald L. Morton,D. R. Wen,Jan H. Wong,James S. Economou,Leslie A. Cagle,F K Storm,Leland J. Foshag,Alistair J. Cochran +7 more
TL;DR: Patients with early stage melanoma who have nodal metastases and are likely to benefit from radical lymphadenectomy are identified, with a high degree of accuracy, by a new procedure developed using vital dyes.
Journal ArticleDOI
An approach for the treatment of penile carcinoma
TL;DR: Preliminary bilateral SLN biopsy is recommended to be followed by inguinofemoroiliac dissection when biopsy of the SLN is positive for metastatic disease, and no further sugical therapy is immediately indicated.