ConclusionMethoxyflurane, like dinitrophenol, acts only on the H+ secretory mechanism in Cl--free solutions. This anesthetic also reveals the linear relationship between the PD and H+ rate and permits estimates of the parameters of the H+ secretory mechanism in Cl--free solutions.

In keeping with the goals of this conference we will focus our attention in this paper on the mechanisms of ion transport across the limiting membranes of the gastric cells. As a result of the analysis of an aspect of gastric HCI secretion we recently have had an interesting spin-off. We found that the established criteria for passive ion transport are not sufficient and we will give a brief account of this later. FIGURE 1 shows the overall problem of ion transport in the stomach. In this figure SEC refers to the secretory or lumen membrane and NUTR refers to the nutrient membrane (the membrane facing the muscularis mucosa or blood side). We will assume initially that there is only one cell type and hence only a single nutrient membrane and a single secretory membrane. Later we will present a more realistic histologic picture. In addition to H' and C1secretion small amounts of Na+, K' and trace amounts of other ions are transported across the gastric mucosa and secreted into the lumen. For simplicity we will in general ignore the problem of Na' and K transport across the whole cell layer and confine our attention to H', C1and HCO3transport. It has been amply demonstrated that CIis actively transported and that a metabolic machine (or machines) is required for the secretion of H' and Cl-.'-* Hydrogen ion and Clare secreted into the lumen and Clenters the cells via the nutrient membrane and HC08appears in the nutrient bathing fluid. The equality of the rate of H' secretion and HCO3appearance in the nutrient bathing solution has been experimentally demonstrated numerous

A Confirmation of Electrogenicity of Frog Gastric Mucosa by Using Methoxyflurane

A Confirmation of Electrogenicity of Frog Gastric Mucosa by Using Methoxyflurane

Citations

IMPLICATIONS OF THE NEUTRAL CARRIER Cl−‐HCO3− EXCHANGE MECHANISM IN GASTRIC MUCOSAfn1

Modern Inhalation Anesthetics

Electrical events during activation and inhibition of gastric HCl secretion.

CHAPTER 6 – Proton Transport

Effect of inhibitors and weak bases on electrophysiology and secretion in frog stomach.

Related Papers (5)

Evidence for an independent hydrogen-ion pump in the stomach.

Effect of dinitrophenol on potential, resistance, and h+ rate of frog stomach.

Voltage response of frog gastric mucosa to direct current.

A Theory of the Formation of HCI by the Stomach

A Model for the Long Time-Constant Transient Voltage Response to Current in Epithelial Tissues